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Displaying 15 of 15 results for "PPM1D"
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  1. Homo sapiens : Homo sapiens Exome BioProject

    ID: PRJNA322354

    Keywords: exome

    Access Type: download

    dataset.description: d to the discovery of tumor-specific mutations in PPM1D, encoding wild-type p53-induced protein phosphatase 1D (WIP1), in 37.5% of the BSGs that harbored hallmark H3F3A mutations encoding p.Lys27Met substitutions. PPM1D mutations were mutually exclusive with TP53 mutations in BSG and attenuated p53 activation in vitro. PPM1D mutations were truncating alterations in exon 6 that enhanced the ability of PPM1D
  2. Murine liver tissues: WT and Wip1 KO mice after Partial Hepatectomy at 24h and 36 h. BioProject

    ID: PRJNA254162

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Murine liver tissues: WT and Wip1 KO mice after Partial Hepatectomy at 24h and 36 h ArrayExpress

    ID: E-GEOD-59023

    Description: Transcriptional profiling of mouse liver tissues comparing Wild type liver tissues with Wip1 KO mice liver tissues after Partial Hepatectomy at 24h an...

  4. Transcription profiling of mouse embryonic fibroblasys from Wip1+/+ or -/- animals after gamma radiation ArrayExpress

    ID: E-GEOD-8704

    Description: Assessment of p53 targets by gene expression array analysis in irradiated and nonirradiated Wip1+/+ and Wip1-/- MEFs. Experiment Overall Design: mRNA ...

  5. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity BioProject

    ID: PRJNA319792

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d negative regulator of p53, the phosphatase Wip1/PPM1D. When combining Nutlin-3a with the Wip1 inhibitor GSK2830371 in the treatment of p53-proficient but not p53-deficient cells, we observed enhanced phosphorylation (Ser 15) and acetylation (Lys 382) of p53, increased expression of p53 target gene products, and synergistic inhibition of cell proliferation. Surprisingly, when testing the two compounds individually, largely distinct sets of genes were induced, as revealed by deep...
  6. Gene expression in Wip1+/+ or -/- MEFs after gamma radiation BioProject

    ID: PRJNA101937

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Expression data from Wild type and Wip1 knockout Hematopoietic stem cell ArrayExpress

    ID: E-GEOD-58754

    Description: Hematopoietic stem cell (HSC) aging underlies many age-related hematopoietic disorders. Accumulation of DNA damage is a hallmark of HSC aging. Wild-ty...

  8. Identification of novel biomarkers associated with poor patient outcome in invasive breast carcinoma ArrayExpress

    ID: E-GEOD-73383

    Description: good and poor prognosis. Up-regulation of B3GNT7, PPM1D, TNKS2, PHB and GTSE1 in patients with poor prognosis was confirmed by quantitative RT-PCR in an independent sample set from patients with BC (47 with good prognosis and 8 that presented metastasis). Expression of BAD protein was investigated by immunohistochemistry in 1276 BC samples and confirmed the reduced expression levels in metastatic cases observed in the oligoarray data. These findings point to novel prognostic markers that can distinguish breast carcinoma samples according to clinical course and progression of the disease. Global expression profiles from 38 ductal breast tumor patient samples were used to search for molecular signatures correlated with current prognostic markers. A subset of 24 cases comprising 15 patients that remained free of disease after surgery and 9 patients that developed metastasis was used to identify candidate biomarkers associated with metastatic progression. Candidates were subsequently validated in additional independent samples by RT-qPCR or immunohistochemistry....

  9. Expression data from Wild type and Wip1 knockout Hematopoietic stem cell BioProject

    ID: PRJNA253355

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Identification of novel biomarkers associated with poor patient outcome in invasive breast carcinoma BioProject

    ID: PRJNA296844

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: good and poor prognosis. Up-regulation of B3GNT7, PPM1D, TNKS2, PHB and GTSE1 in patients with poor prognosis was confirmed by quantitative RT-PCR in an independent sample set from patients with BC (47 with good prognosis and 8 that presented metastasis). Expression of BAD protein was investigated by immunohistochemistry in 1276 BC samples and confirmed the reduced expression levels in metastatic cases observed in the oligoarray data. These findings point to novel prognostic markers that can distinguish breast carcinoma samples according to clinical course and progression of the disease. Overall design: Global expression profiles from 38 ductal breast tumor patient samples were used to search for molecular signatures correlated with current prognostic markers. A subset of 24 cases comprising 15 patients that remained free of disease after surgery and 9 patients that developed metastasis was used to identify candidate biomarkers associated with metastatic progression. Candidates were subsequently validated in additional independent samples by RT-qPCR or immunohistochemistry....
  11. Wip1 regulates adult neurogenesis and Wnt signaling during aging ArrayExpress

    ID: E-GEOD-57105

    Description: The number of newly-formed neurons declines rapidly during aging. Here we describe an important mechanism that contributes to this decline via Wip1-de...

  12. WIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation ArrayExpress

    ID: E-GEOD-46103

    Description: WIP1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. Here we found that WIP...

  13. Identification of novel biomarkers associated with poor patient outcome in invasive breast carcinoma OmicsDI

    ID: E-GEOD-73383

    Date Released: 07-02-2016

    Description: good and poor prognosis. Up-regulation of B3GNT7, PPM1D, TNKS2, PHB and GTSE1 in patients with poor prognosis was confirmed by quantitative RT-PCR in an independent sample set from patients with BC (47 with good prognosis and 8 that presented metastasis). Expression of BAD protein was investigated by immunohistochemistry in 1276 BC samples and confirmed the reduced expression levels in metastatic cases observed in the oligoarray data. These findings point to novel prognostic markers that can distinguish breast carcinoma samples according to clinical course and progression of the disease. Global expression profiles from 38 ductal breast tumor patient samples were used to search for molecular signatures correlated with current prognostic markers. A subset of 24 cases comprising 15 patients that remained free of disease after surgery and 9 patients that developed metastasis was used to identify candidate biomarkers associated with metastatic progression. Candidates were subsequently validated in additional independent samples by RT-qPCR or immunohistochemistry....

  14. Wip1 regulates adult neurogenesis and Wnt signaling during aging BioProject

    ID: PRJNA245440

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. WIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation BioProject

    ID: PRJNA197260

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 15 of 15 results for "PPM1D"