PPM1A | bioCADDIE Data Discovery Index
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Displaying 19 of 19 results for "PPM1A"
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  1. SMAD2_HUMAN UniProt:Swiss-Prot

    ID: Q15796

    Description: sphoserine; by TGFBR1 Phosphoserine; by TGFBR1 In isoform Short. In a colorectal carcinoma sample. In a colorectal cancer sample; somatic mutation. In a colorectal carcinoma sample. In a colorectal carcinoma sample. In a colorectal carcinoma sample. In a colorectal carcinoma sample. Loss of acetylation No effect on acetylation Loss of binding to SMURF2 Loss of interaction with PMEPA1 Loss of binding to SARA Increased binding to PPM1A

  2. PP2Ca PDB

    ID: PDB:4RA2

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  3. Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 10 mM of Mn2+ PDB

    ID: PDB:3FXM

    Description: Protein phosphatase 1A(E.C.3.1.3.16)

  4. Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+ PDB

    ID: PDB:3FXO

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  5. Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 1 mM of Mn2+ PDB

    ID: PDB:3FXL

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  6. Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+ PDB

    ID: PDB:3FXK

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  7. Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 3 mM of Mn2+ PDB

    ID: PDB:3FXJ

    Description: Protein phosphatase 1A(E.C.3.1.3.16)

  8. Crystal structure of PP2Ca-D38A PDB

    ID: PDB:4RAF

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  9. Crystal Structure of PYL13-PP2CA complex PDB

    ID: PDB:4N0G

    Description: Protein phosphatase 2C 37 (E.C.3.1.3.16), Abscisic acid receptor PYL13

  10. Transcriptome of MEFs with BMP2 and DNA damage reagents BioProject

    ID: PRJNA156899

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 9 phosphorylation disrupts Smad1 interaction with protein phosphatase PPM1A and enhances Smad1 activation and up-regulation, which not only turns on target genes including Cdk1nc but also interacts with p53 and inhibits Mdm2-mediated p53 ubiquitination, leading to p53 stabilization. Functionally, Smad1 acts like a tumor suppressor in DNA damage response, cell transformation and tumorigenesis in a p53-dependent manner. Sequencing of the gastric cancer samples revealed that Smad1 is frequently mutated, with S239 as mutational hotspot. This study thus establishes the BMP-Smad1 pathway as an integral part of DNA damage response, whi...
  11. Transcriptome of MEFs with BMP2 and DNA damage reagents ArrayExpress

    ID: E-GEOD-36843

    Description: 9 phosphorylation disrupts Smad1 interaction with protein phosphatase PPM1A and enhances Smad1 activation and up-regulation, which not only turns on target genes including Cdk1nc but also interacts with p53 and inhibits Mdm2-mediated p53 ubiquitination, leading to p53 stabilization. Functionally, Smad1 acts like a tumor suppressor in DNA damage response, cell transformation and tumorigenesis in a p53-dependent manner. Sequencing of the gastric cancer samples revealed that Smad1 is frequently mutated, with S239 as mutational hotspot. This study thus establishes the BMP-Smad1 pathway as an integral part of DNA damage response, whi...

  12. PPM1A_BOVIN UniProt:Swiss-Prot

    ID: O62829

    Description: Removed Protein phosphatase 1A PPM-type phosphatase Manganese 1 Manganese 2 Mangan...

  13. CRYSTAL STRUCTURE of PPC2A-D38K PDB

    ID: PDB:4RAG

    Description: Protein phosphatase 1A (E.C.3.1.3.16)

  14. Transcriptome of MEFs with BMP2 and DNA damage reagents OmicsDI

    ID: E-GEOD-36843

    Date Released: 06-02-2014

    Description: 9 phosphorylation disrupts Smad1 interaction with protein phosphatase PPM1A and enhances Smad1 activation and up-regulation, which not only turns on target genes including Cdk1nc but also interacts with p53 and inhibits Mdm2-mediated p53 ubiquitination, leading to p53 stabilization. Functionally, Smad1 acts like a tumor suppressor in DNA damage response, cell transformation and tumorigenesis in a p53-dependent manner. Sequencing of the gastric cancer samples revealed that Smad1 is frequently mutated, with S239 as mutational hotspot. This study thus establishes the BMP-Smad1 pathway as an integral part of DNA damage response, whi...

  15. PYL13_ARATH UniProt:Swiss-Prot

    ID: Q9SN51

    Description: with PP2Cs Involved in ABA binding Becomes an ABA-dependent inhibitor of PP2Cs, including PP2CA, ABI1, HAB1, and HAB2; when associated with L-71 Becomes an ABA-dependent inhibitor of PP2Cs, including PP2CA, ABI1, HAB1, and HAB2; when associated with K-38...

  16. Crystal structure of dimeric abscisic acid (ABA) receptor pyrabactin resistance 1 (PYR1) with ABA-bound closed-lid and ABA-free open-lid subunits PDB

    ID: PDB:3K3K

    Description: Abscisic acid receptor PYR1

    datasetDistributions.storedIn: Protein Data Bank
  17. 109 Metabolomics

    Study Name: High insulin combined with essential amino acids stimulates skeletal muscleprotein synthesis while decreasing insulin sensitivity in healthy humans

    Grant ID: U01 DK097430-01

    Grant: 5T32DK007352, 5R01DK041973, UL1 TR000135, U24DK100469

    dataAnalysis.keywords: Muscle protein enrichment was determined using HPLC and tandem mass(MS/MS) as described previously (19). HPLC-MS/MS has superior precision...
  18. Expression profiles dysplastic and neoplastic rat liver lesions BioProject

    ID: PRJNA132391

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: DN, and Bhmt, Dmbt1, Dusp1, Gadd45g, Gnmt, Napsa, Pp2ca, and Ptpn13, in HCC, was higher in BN than F344 rats. Comparative genomics approach, using gene expression data from rat lesions, and human HCC with different prognosis (based on survival length), revealed expression patterns of BN and F344 lesions close to those of human HCCs with better and poorer prognosis, respectively, suggesting that similar molecular events contribute to create a phenotype prone to progression in rats and human lesions. In conclusion, we identified a molecular signature of DN prone to progress to HCC and suggest that oncosuppressor genes are determinants of the genetically transmitted resistance to hepatocarcinogenesis. Overall design: Three-condition experiment, Normal liver vs. Dysplastic nodules and tumors. Biological replicates: 8 control replicates, 8 nodules replicates and 7 tumor replicates....
  19. Expression profiles dysplastic and neoplastic rat liver lesions GEMMA

    ID: 1959

    Keywords: functional genomics

    Description: DN, and Bhmt, Dmbt1, Dusp1, Gadd45g, Gnmt, Napsa, Pp2ca, and Ptpn13, in HCC, was higher in BN than F344 rats. Comparative genomics approach, using gene expression data from rat lesions, and human HCC with different prognosis (based on survival length), revealed expression patterns of BN and F344 lesions close to those of human HCCs with better and poorer prognosis, respectively, suggesting that similar molecular events contribute to create a phenotype prone to progression in rats and human lesions. In conclusion, we identified a molecular signature of DN prone to progress to HCC and suggest that oncosuppressor genes are determinants of the genetically transmitted resistance to hepatocarcinogenesis. Last Updated (by provider): Oct 13 2010...


Displaying 19 of 19 results for "PPM1A"