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Displaying 20 of 56 results for "PMEL"
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  1. Pmel CD8+ stim 1 vs. stim 2 BioProject

    ID: PRJNA91639

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Real-time quantitative PCR analysis for miRNA in mouse CD8+ pMel-1 T cells BioProject

    ID: PRJNA259740

    Keywords: Other

    Access Type: download

  3. Mus musculus strain:PMEL-1 TCR transgenic C57BL/6 : Mus musculus strain:PMEL-1 TCR transgenic C57BL/6 Genome sequencing BioProject

    ID: PRJNA238124

    Keywords: genome sequencing

    Access Type: download

    dataset.description: The pmel-1 transgenic mouse has been extensively employed as a model system to study the mechanisms of tumor immunology, CD8+ T cell di...
  4. Murine CD8+ Pmel Lymphocytes IL-2 vs. IL-15 BioProject

    ID: PRJNA91983

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Cross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects OmicsDI

    ID: E-GEOD-79475

    Date Released: 06-18-2016

    Description: ed and unstimulated T cell receptor transgenic ‘pmel’ and MyD88-/-pmel CD8+ T cells and identified changes in the expression levels of several TNF family members. In particular, TLR-stimulation increased 4-1BB levels in pmel but not in MyD88-/-pmel T cells. A link between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells was highlighted by in fact that 4-1BB-/- T cells exhibited suboptimal responses to TLR1-TLR2 agonist, but responded normally to CD28 or OX40 costimulation. Moreover...

  6. Cross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects ArrayExpress

    ID: E-GEOD-79475

    Description: ed and unstimulated T cell receptor transgenic ‘pmel’ and MyD88-/-pmel CD8+ T cells and identified changes in the expression levels of several TNF family members. In particular, TLR-stimulation increased 4-1BB levels in pmel but not in MyD88-/-pmel T cells. A link between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells was highlighted by in fact that 4-1BB-/- T cells exhibited suboptimal responses to TLR1-TLR2 agonist, but responded normally to CD28 or OX40 costimulation. Moreover...

  7. Pmel CD8+ stim 1 vs. stim 2 ArrayExpress

    ID: E-GEOD-2348

    Description: Repeat experiments of CD8+ pmel effector cells following one and two rounds of restimulation

  8. Pmel CD8+ stim 1 vs. stim 2 OmicsDI

    ID: E-GEOD-2348

    Date Released: 03-27-2012

    Description: Repeat experiments of CD8+ pmel effector cells following one and two rounds of restimulation

  9. Expression data for naïve IL-2 and IL-12 primed Pmel-1 CD8+ T-cells BioProject

    ID: PRJNA128523

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Cross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects BioProject

    ID: PRJNA315950

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed and unstimulated T cell receptor transgenic ‘pmel’ and MyD88-/-pmel CD8+ T cells and identified changes in the expression levels of several TNF family members. In particular, TLR-stimulation increased 4-1BB levels in pmel but not in MyD88-/-pmel T cells. A link between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells was highlighted by in fact that 4-1BB-/- T cells exhibited suboptimal responses to TLR1-TLR2 agonist, but responded normally to CD28 or OX40 costimulation. Moreover...
  11. Expression data for naïve IL-2 and IL-12 primed Pmel-1 CD8+ T-cells OmicsDI

    ID: E-GEOD-22443

    Date Released: 06-10-2011

    Description: ypically and functionally similar to IL-12 primed Pmel-1 T-cells. These results highlight IL-12 as an important mediator of CD8+ T-cell effector function and anti-tumor immunity. We primed Pmel-1 TCR transgenic CD8+ T-cells with cognate antigen and either IL-2 or IL-12 and compared their gene expression profiles. This was used to identify pathways or genes necessary for anti-tumor activity in vivo. RNA was isolated from Pmel-1 T-cells primed with antigen and cytokine for 6 days and hybridized to Affymetrix arrays....

  12. Melanomas enhance metastasis and resist BRAF-therapy through regulation of the scaffold protein FHL2 after loss of differentiation markers BioProject

    ID: PRJNA246423

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: To test whether or not the stable restoration of PMEL and FHL2 knockdown affects the oncogenic ability of into amelanotic melanoma cells. Global gene expression analysis performed ...
  13. PMEL_MOUSE UniProt:Swiss-Prot

    ID: Q60696

    Description: Melanocyte protein PMEL M-alpha M-beta Lumenal Helical Cytoplasmic PKD 1 2 3 4 5 6 7 7 X 13 AA approximate tandem repeats, RPT domain N-linked (GlcNAc...

  14. Expression data for naïve IL-2 and IL-12 primed Pmel-1 CD8+ T-cells ArrayExpress

    ID: E-GEOD-22443

    Description: ypically and functionally similar to IL-12 primed Pmel-1 T-cells. These results highlight IL-12 as an important mediator of CD8+ T-cell effector function and anti-tumor immunity. We primed Pmel-1 TCR transgenic CD8+ T-cells with cognate antigen and either IL-2 or IL-12 and compared their gene expression profiles. This was used to identify pathways or genes necessary for anti-tumor activity in vivo. RNA was isolated from Pmel-1 T-cells primed with antigen and cytokine for 6 days and hybridized to Affymetrix arrays....

  15. MCOA : Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMEL BioProject

    ID: PRJEB4316

    Keywords: Other

    Access Type: download

  16. Gene expression profile of MITF expressing cells OmicsDI

    ID: E-GEOD-38007

    Date Released: 08-18-2015

    Description: ll lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment ...

  17. Gene expression profile of MITF expressing cells ArrayExpress

    ID: E-GEOD-38007

    Description: ll lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment ...

  18. Improved antitumor activity of immunotherapy combined with BRAF and MEK inhibitors in BRAFV600E mutant melanoma OmicsDI

    ID: E-GEOD-64102

    Date Released: 01-02-2015

    Description: ib. Combination of dabrafenib and trametinib with pmel-1 adoptive cell transfer (ACT) showed complete tumor regression. Bioluminescent imaging and tumor infiltrating lymphocyte (TIL) phenotyping showed increased effector infiltration to tumors with dabrafenib, trametinib or dabrafenib plus trametinib with pmel-1 ACT combination. Intracellular IFN gamma staining of the TILs and in vivo cytotoxicity studies showed trametinib was not detrimental to the effector functions in vivo. Dabrafenib increased tumor associated macrophages and T regulatory cells (Tregs) in the tumors, which can be overcome by addition of trametinib. Microarray analysis revealed increased melanoma antigen, MHC expression, and global immune-related gene upregulation with the triple combination therapy. Given the up-regulation of PD-L1 seen w...

  19. Crystal structure of HLA-DR4 bound to GP100 peptide PDB

    ID: PDB:4IS6

    Description: ty antigen, DRB1-4 beta chain, Melanocyte protein PMEL...

  20. Murine CD8+ Pmel Lymphocytes IL-2 vs. IL-15 ArrayExpress

    ID: E-GEOD-2578

    Description: Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells


Displaying 20 of 56 results for "PMEL"