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Displaying 20 of 20 results for "PLTP"
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  1. PARK4blood : BLOOD BIOMARKERS OF RISK FOR SYNUCLEINOPATHY, A VARIANT OF PARKINSON’S DISEASE BioProject

    ID: PRJEB8960

    Keywords: Other

    Access Type: download

    dataset.description: egranulation was impaired. Strong SPP1, GZMH, and PLTP mRNA upregulations were validated in PARK4. Analysing prodromal stages of general PD, only blood CPLX1 levels were altered in cases with REM sleep behaviour disorder (RBD). Validation experiments confirmed an inverse mutual regulation of SNCA and CPLX1 mRNA levels. In the 3’-UTR of the CPLX1 gene we identified a SNP that is significantly associated with PD risk. In summary, our data provide functional insights into the role and regulation of blood alpha-synuclein levels. The novel blood biomarkers of synucleinopathy may become useful for PD prediction....
  2. Next Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis ArrayExpress

    ID: E-GEOD-65267

    Description: eceptor C1 (MRC1), phospholipid transfer protein (PLTP), are detectable in human urine. Furthermore, the levels of CDH11 and MRC1 are able to distinguish patients with chronic kidney disease from healthy individuals (n = 78, p<0.01). In summary, we report the identification of CDH11 and MRC1 as novel non-invasive biomarkers of CKD. mRNA sequencing of mouse kidney before and at various time points (1,2,3,7 & 14 days) after intraperitoneal treatment with folic acid....

  3. Exacerbated neuronal ceroid lipofuscinosos phenotype in Cln1/5 double knock-out mice ArrayExpress

    ID: E-GEOD-37643

    Description: increase in serum phospholipid transfer protein (PLTP) activity. Finally, gene expression profiling of Cln1/5 dko cortex revealed defects in myelination and immune response pathways, with a prominent downregulation of alpha-synuclein in Cln1/5 dko mouse brains. The simultaneous loss of both Cln1 and Cln5 genes may enhance the typical pathological phenotypes of these mice by disrupting down shared or convergent pathogenic pathways, which may potentially include interactions of CLN1 and CLN5. Basic characterization of Cln1/5 double knock-out mouse model. Aim was to find possible differentially expressed genes and up-or downregulated pathways in Cln1/5 double knock-out vs. wild-type mouse cortex. Total RNA isolated from 1 month old Cln1-/-/Cln5-/- mouse cortex....

  4. Coenzyme Q10-dependent gene expression in SAMP1 mice tissues ArrayExpress

    ID: E-GEOD-15129

    Description: fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1). Thus, we provide evidence that QH2 is involved in the reduction of fat and cholesterol synthesis via modulation of the PPAR-α signalling pathway. These data may explain, at least in part, the observed effects on decelerated age-dependent degeneration processes in QH2-supplemented SAMP1 mice. Whole genome expression profiles were analysed from liver, heart, brain and kidney (each analyzed separately) of SAMP1 mice supplemented with QH2, Q10 or a control diet. From every experimental group, three mice each were sacrificed 6 or 14 months after supplementation, resulting in a total of 72 microarrays....

  5. Coenzyme Q10-dependent gene expression in SAMP1 mice tissues BioProject

    ID: PRJNA114949

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1). Thus, we provide evidence that QH2 is involved in the reduction of fat and cholesterol synthesis via modulation of the PPAR-α signalling pathway. These data may explain, at least in part, the observed effects on decelerated age-dependent degeneration processes in QH2-supplemented SAMP1 mice. Overall design: Whole genome expression profiles were analysed from liver, heart, brain and kidney (each analyzed separately) of SAMP1 mice supplemented with QH2, Q10 or a control diet. From every experimental group, three mice each were sacrificed 6 or 14 months after supplementation, resulting in a total of 72 microarrays....
  6. Next Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis BioProject

    ID: PRJNA273550

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eceptor C1 (MRC1), phospholipid transfer protein (PLTP), are detectable in human urine. Furthermore, the levels of CDH11 and MRC1 are able to distinguish patients with chronic kidney disease from healthy individuals (n = 78, p<0.01). In summary, we report the identification of CDH11 and MRC1 as novel non-invasive biomarkers of CKD. Overall design: mRNA sequencing of mouse kidney before and at various time points (1,2,3,7 & 14 days) after intraperitoneal treatment with folic acid....
  7. Exacerbated neuronal ceroid lipofuscinosos phenotype in Cln1/5 double knock-out mice BioProject

    ID: PRJNA162369

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: increase in serum phospholipid transfer protein (PLTP) activity. Finally, gene expression profiling of Cln1/5 dko cortex revealed defects in myelination and immune response pathways, with a prominent downregulation of alpha-synuclein in Cln1/5 dko mouse brains. The simultaneous loss of both Cln1 and Cln5 genes may enhance the typical pathological phenotypes of these mice by disrupting down shared or convergent pathogenic pathways, which may potentially include interactions of CLN1 and CLN5. Overall design: Basic characterization of Cln1/5 double knock-out mouse model. Aim was to find possible differentially expressed genes and up-or downregulated pathways in Cln1/5 double knock-out vs. wild-type mouse cortex. Total RNA isolated from 1 month old Cln1-/-/Cln5-/- mouse cortex....
  8. Exacerbated neuronal ceroid lipofuscinosos phenotype in Cln1/5 double knock-out mice OmicsDI

    ID: E-GEOD-37643

    Date Released: 11-08-2012

    Description: increase in serum phospholipid transfer protein (PLTP) activity. Finally, gene expression profiling of Cln1/5 dko cortex revealed defects in myelination and immune response pathways, with a prominent downregulation of alpha-synuclein in Cln1/5 dko mouse brains. The simultaneous loss of both Cln1 and Cln5 genes may enhance the typical pathological phenotypes of these mice by disrupting down shared or convergent pathogenic pathways, which may potentially include interactions of CLN1 and CLN5. Basic characterization of Cln1/5 double knock-out mouse model. Aim was to find possible differentially expressed genes and up-or downregulated pathways in Cln1/5 double knock-out vs. wild-type mouse cortex. Total RNA isolated from 1 month old Cln1-/-/Cln5-/- mouse cortex....

  9. Coenzyme Q10-dependent gene expression in SAMP1 mice tissues OmicsDI

    ID: E-GEOD-15129

    Date Released: 09-07-2015

    Description: fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1). Thus, we provide evidence that QH2 is involved in the reduction of fat and cholesterol synthesis via modulation of the PPAR-α signalling pathway. These data may explain, at least in part, the observed effects on decelerated age-dependent degeneration processes in QH2-supplemented SAMP1 mice. Whole genome expression profiles were analysed from liver, heart, brain and kidney (each analyzed separately) of SAMP1 mice supplemented with QH2, Q10 or a control diet. From every experimental group, three mice each were sacrificed 6 or 14 months after supplementation, resulting in a total of 72 microarrays....

  10. Next Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis OmicsDI

    ID: E-GEOD-65267

    Date Released: 12-08-2015

    Description: eceptor C1 (MRC1), phospholipid transfer protein (PLTP), are detectable in human urine. Furthermore, the levels of CDH11 and MRC1 are able to distinguish patients with chronic kidney disease from healthy individuals (n = 78, p<0.01). In summary, we report the identification of CDH11 and MRC1 as novel non-invasive biomarkers of CKD. mRNA sequencing of mouse kidney before and at various time points (1,2,3,7 & 14 days) after intraperitoneal treatment with folic acid....

  11. Coenzyme Q10-dependent gene expression in SAMP1 mice tissues GEMMA

    ID: 1871

    Keywords: functional genomics

    Description: fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1). Thus, we provide evidence that QH2 is involved in the reduction of fat and cholesterol synthesis via modulation of the PPAR-? signalling pathway. These data may explain, at least in part, the observed effects on decelerated age-dependent degeneration processes in QH2-supplemented SAMP1 mice. Last Updated (by provider): Mar 05 2009 Contributers: Frank Döring Hiroshi Kubo Constance Schmelzer Keiichi Higuchi...

  12. Genome-wide mapping of expression in WT and p63 mutant mouse mandibular prominences at E10-E13 BioProject

    ID: PRJNA358575

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: togenesis or the p63 pathway (e.g, Fermt1, Cbln1, Pltp, Cxcl14, Krt8, and additional keratin and claudin family members). As expected, from E10-E13 few genes known to regulate mandible morphogenesis differed in expression between mouse strains. Thus this study links for the first time several genes to odontogenesis and/or the p63 signaling network. We propose that these genes act in a novel odontogenic network that is exclusive of lower jaw morphogenesis, and posit that this network evolved in oral, not pharyngeal, teeth. Overall design: All experiments used mouse tissues from the B6.129S7-Trp63tm2Brd/J (generated by Mills et al., (1999)) and C57BL6/J strains (The Jackson Laboratory/JAX). We refer to mice with both copies of the mutant p63 allele as homozygote or p63-/-. The p63+/- samples represent B6.129S7-Trp63tm2Brd/J and p63-/- represent embryos from crosses of B6.129S7-Trp63tm2Brd/J x B6.129S7-Trp63tm2Brd/J mice. For each stage, p63-/- and p63+/- littermates were collected to minimize between-litter variation within each genotype. Also for each stage, three biological replicates (i.e., three embryos, each from a different litter) were assayed per genotype. Samples were not pooled between litters....
  13. B6BTBRF2Publish-10024 GeneNetwork

    ID: B6BTBRF2Publish-10024

    Description: Delta Ct numbers of phospholipid transfer protein (U28960) measured by quatitative real-time RT-PCR

  14. Diet-induced changes in plasma phospholipid transfer protein activity, lipids, and lipoproteins in 15 inbred strains of mice MPD

    Data Type: strain

    Size: 15

    ID: MPD:19

  15. MDPPublish-10820 GeneNetwork

    ID: MDPPublish-10820

    Description: phospholipid transfer protein activity, atherogenic diet (female)

  16. MDPPublish-10813 GeneNetwork

    ID: MDPPublish-10813

    Description: phospholipid transfer protein activity, normal diet (female)

  17. MDPPublish-30813 GeneNetwork

    ID: MDPPublish-30813

    Description: phospholipid transfer protein activity, normal diet (male)

  18. MDPPublish-30821 GeneNetwork

    ID: MDPPublish-30821

    Description: fold change in phospholipid transfer protein activity after 6 wks on atherogenic diet (male)

  19. MDPPublish-30820 GeneNetwork

    ID: MDPPublish-30820

    Description: phospholipid transfer protein activity, atherogenic diet (male)

  20. MDPPublish-10821 GeneNetwork

    ID: MDPPublish-10821

    Description: fold change in phospholipid transfer protein activity after 6 wks on atherogenic diet (female)


Displaying 20 of 20 results for "PLTP"