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Displaying 5 of 5 results for "PLIN1"
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  1. Development of gene expression signatures in testis for plin1-null mice BioProject

    ID: PRJNA171693

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Development of gene expression signatures in testis for plin1-null mice ArrayExpress

    ID: E-GEOD-39769

    Description: as a discovery platform to identify the effect of plin1 on gene expression during testis development. Testis of day 21, day 40, and day 60 in plin1-null mice and wild type mice were analyzed. Expression of a list genes (incl...

  3. Development of gene expression signatures in testis for plin1-null mice OmicsDI

    ID: E-GEOD-39769

    Date Released: 06-02-2014

    Description: as a discovery platform to identify the effect of plin1 on gene expression during testis development. Testis of day 21, day 40, and day 60 in plin1-null mice and wild type mice were analyzed. Expression of a list genes (incl...

  4. Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-Derived Mesenchymal Stem Cells (RNA-seq) BioProject

    ID: PRJNA317058

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: idly altered near the Adipoq, Cidec, Fabp4, Lipe, Plin1, Pparg and Cebpa genes during adipogenic differentiation. Surprisingly, we found that these cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice-versa) after commitment, as assessed by staining, gene expression, and ChIP-qPCR analysis. The osteogenic default pathway may be subverted during pathological conditions leading to skeletal fragility and increased marrow adipocity during aging, estrogen deficiency and skeletal unloading. Taken together, our data provide an increased mechanistic understanding of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove beneficial in the development of therapeutic strategies. Overall design: Marrow derived MSC cells were differentiated to day 7 or day 15 with osteogenic or adipogenic media. These cells were then treated with vehicle or 100nM 1,25(OH)2D3 for 24 hours prior to mRNA isolation and sequencing....
  5. Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-Derived Mesenchymal Stem Cells (ChIP-seq) BioProject

    ID: PRJNA317059

    Keywords: Epigenomics

    Access Type: download

    dataset.description: idly altered near the Adipoq, Cidec, Fabp4, Lipe, Plin1, Pparg and Cebpa genes during adipogenic differentiation. Surprisingly, we found that these cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice-versa) after commitment, as assessed by staining, gene expression, and ChIP-qPCR analysis. The osteogenic default pathway may be subverted during pathological conditions leading to skeletal fragility and increased marrow adipocity during aging, estrogen deficiency and skeletal unloading. Taken together, our data provide an increased mechanistic understanding of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove beneficial in the development of therapeutic strategies. Overall design: Marrow derived MSC cells were differentiated to day 7 or day 15 with osteogenic or adipogenic media. These cells were then treated with vehicle or 100nM 1,25(OH)2D3 for 24 hours prior to ChIP assay, library creation and sequencing....

Displaying 5 of 5 results for "PLIN1"