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Displaying 20 of 20 results for "PLIN1"
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  1. Development of gene expression signatures in testis for plin1-null mice BioProject

    ID: PRJNA171693

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Development of gene expression signatures in testis for plin1-null mice ArrayExpress

    ID: E-GEOD-39769

    Description: as a discovery platform to identify the effect of plin1 on gene expression during testis development. Testis of day 21, day 40, and day 60 in plin1-null mice and wild type mice were analyzed. Expression of a list genes (incl...

  3. Development of gene expression signatures in testis for plin1-null mice OmicsDI

    ID: E-GEOD-39769

    Date Released: 06-02-2014

    Description: as a discovery platform to identify the effect of plin1 on gene expression during testis development. Testis of day 21, day 40, and day 60 in plin1-null mice and wild type mice were analyzed. Expression of a list genes (incl...

  4. PLIN3_PIG UniProt:Swiss-Prot

    ID: Q5BLZ2

    Description: Removed Perilipin-3 N6-acetyllysine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine...

  5. PLIN1_RAT UniProt:Swiss-Prot

    ID: P43884

    Description: Perilipin-1 Required for interaction with CIDEC Poly-Glu Phosphoserine Phosphothreonine Phosphoserine Phosphoser...

  6. PLIN2_PIG UniProt:Swiss-Prot

    ID: Q4PLW0

    Description: Removed Perilipin-2 N-acetylalanine Phosphoserine

  7. PLIN3_PONAB UniProt:Swiss-Prot

    ID: Q5RAV8

    Description: Removed Perilipin-3 N-acetylserine Phosphoserine N6-acetyllysine Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine P...

  8. PLIN5_RAT UniProt:Swiss-Prot

    ID: M0R7Z9

    Description: Perilipin-5 Essential for lipid droplet targeting Interaction with LIPE Interaction with PNPLA2 and ABHD5 Recruits mitochondria at ...

  9. PLIN5_BOVIN UniProt:Swiss-Prot

    ID: A6QLL0

    Description: Perilipin-5 Essential for lipid droplet targeting Interaction with LIPE Interaction with PNPLA2 and ABHD5 Recruits mitochondria at ...

  10. Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-Derived Mesenchymal Stem Cells (RNA-seq) BioProject

    ID: PRJNA317058

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: idly altered near the Adipoq, Cidec, Fabp4, Lipe, Plin1, Pparg and Cebpa genes during adipogenic differentiation. Surprisingly, we found that these cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice-versa) after commitment, as assessed by staining, gene expression, and ChIP-qPCR analysis. The osteogenic default pathway may be subverted during pathological conditions leading to skeletal fragility and increased marrow adipocity during aging, estrogen deficiency and skeletal unloading. Taken together, our data provide an increased mechanistic understanding of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove beneficial in the development of therapeutic strategies. Overall design: Marrow derived MSC cells were differentiated to day 7 or day 15 with osteogenic or adipogenic media. These cells were then treated with vehicle or 100nM 1,25(OH)2D3 for 24 hours prior to mRNA isolation and sequencing....
  11. Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-Derived Mesenchymal Stem Cells (ChIP-seq) BioProject

    ID: PRJNA317059

    Keywords: Epigenomics

    Access Type: download

    dataset.description: idly altered near the Adipoq, Cidec, Fabp4, Lipe, Plin1, Pparg and Cebpa genes during adipogenic differentiation. Surprisingly, we found that these cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice-versa) after commitment, as assessed by staining, gene expression, and ChIP-qPCR analysis. The osteogenic default pathway may be subverted during pathological conditions leading to skeletal fragility and increased marrow adipocity during aging, estrogen deficiency and skeletal unloading. Taken together, our data provide an increased mechanistic understanding of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove beneficial in the development of therapeutic strategies. Overall design: Marrow derived MSC cells were differentiated to day 7 or day 15 with osteogenic or adipogenic media. These cells were then treated with vehicle or 100nM 1,25(OH)2D3 for 24 hours prior to ChIP assay, library creation and sequencing....
  12. Expression data from white adipose tissue of Perilipin A transgenic mice ArrayExpress

    ID: E-GEOD-21754

    Description: Perilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Adipocyte spe...

  13. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels ArrayExpress

    ID: E-GEOD-38590

    Description: control proper lipid storage in skeletal muscle. Perilipin 2 (PLIN2/ADRP) is one of the most abundantly expressed LD-coating proteins in skeletal muscle. Here we examined the role of PLIN2 in myocellular lipid handling and insulin sensitivity by investigating the effects of in vitro PLIN2 knockdown and in vitro and in vivo overexpression. PLIN2 knockdown decreased LD formation and triacylglycerol storage, marginally increased FA oxidation, and increased incorp...

  14. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitiv... ArrayExpress

    ID: E-GEOD-43832

    Description: overexpression of the lipid droplet coat protein perilipin 2 augments intramyocellular lipid content while improving insulin sensitivity. Another member of the perilipin family, perilipin 5 (PLIN5), is predominantly expressed in oxidative tissues like skeletal muscle. Here we investigated the effects of PLIN5 overexpression – in comparison with effects of PLIN2 – on skeletal muscle lipid levels, gene e...

  15. PLIN5_SHEEP UniProt:Swiss-Prot

    ID: B0FJL7

    Description: Perilipin-5 Essential for lipid droplet targeting Interaction with LIPE Interaction with PNPLA2 and ABHD5 Recruits mitochondria at ...

  16. HF liver: Control vs. Plin2-ASO treated ArrayExpress

    ID: E-GEOD-37011

    Description: rambled-oligonucleotides (Cont)-treated mice with Perilipin 2-antisense oligonucleotides (Plin2-ASO)-treated mice. C57BL/6 mice on a high-fat diet were treated with oligonucleotides in vivo. The goal was to determine the effects of Plin2 down-...

  17. Cardiomyocyte specific plin5 over expression ArrayExpress

    ID: E-GEOD-44192

    Description: lin5 over-expression (MHC-plin5), a member of the perilipin protein family. Hearts from MHC-plin5 mice expressed at least 4-fold higher levels of plin5 and exhibit a 3.5- fold increase in triglyceride content versus non-transgenic littermate. Chronic cardiac excess of LDs was found to result in mild heart dysfunction with decreased expression of PPARα target genes, decreased mitochondria function and left ventricular concentric hypertrophia. Lack of more severe heart function complications may have been prevented by a strong increased expression of oxidative induced genes via NF-E2-related factor 2 anti-oxidative pathway. Perilipin 5 regulates the formation and stabilization of cardiac LDs, and promotes cardiac steatosis without major heart function im...

  18. Transcription profiling of murine db/db diabetic kidney to identify adipose differentiation-related protein and regulators of lipid homeostasis ArrayExpress

    ID: E-GEOD-642

    Description: RNA of Kidney was extracted using a Quiagen RNeasy kit. Targets were produced using standard Affymetrix procedures from about 8ug of total RNA.

    datasetDistributions.accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-642/E-GEOD-642.raw.1.zip
  19. Identification of new genes involved in human adipogenesis and fat storage ArrayExpress

    ID: E-GEOD-28628

    Description: nesis and neutral lipid storage (like PPAR?, RXR, Perilipin A) the screening revealed a large number of genes which were not previously described in the context of fatty tissue biology. An enrichment of genes was observed for axonemal dyneins. Five out of ten anxonemal dyneins were identified in our primary screen and retested positive with independent siRNAs and cell-donors. Quantitative RT-PCR- and immunoblot analysis revealed that axonemal dyneins are expressed in preadipocytes and maturing adipocytes. Using microarray analysis, we further characterize the remaining genes identified in our primary screen to determine their expression pattern during adipogenesis. In the course of fat cell differentiation, 149 among the 459 positive genes were regulated on the gene expression level. Assuming...

  20. Transcription profiling of human glucose-dependent insulinotropic peptide (GIP)- and adrenocorticotropin-dependent adrenal hyperplasias reveals novel ... ArrayExpress

    ID: E-GEOD-4060

    Description: classes. Specific findings include repression of perilipin, the overexpression of 13 G protein-coupled receptors, and the potential involvement of Rho-GTPases. We also isolated 94 probe sets potentially linked to the formation of GIP-dependent nodules adjacent to the diffuse hyperplasia. These included probe sets related to the linker histone H1 and repression of RXRa and CCND2. The expression profiles for eight genes were confirmed by real-time RT-PCR. CONCLUSION: This study identified an extensive series of potentially novel target candidate genes that could be implicated in the molecular mechanisms of ectopic expression of the GIPR as well as in the multistep progression of GIP-dependent CS....


Displaying 20 of 20 results for "PLIN1"