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Displaying 20 of 8,398 results for "PKN3"
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  1. PKN3_MYXXA UniProt:Swiss-Prot

    ID: Q9XBQ0

    Description: Serine/threonine-protein kinase pkn3 Protein kinase ATP Proton acceptor ...

  2. PKN3_MOUSE UniProt:Swiss-Prot

    ID: Q8K045

    Description: Serine/threonine-protein kinase N3 REM 1 REM 2 REM 3 Protein kinase AGC-...

  3. Effect of Ursodeoxycholic acid on gene expression in the intestial epithelium ArrayExpress

    ID: E-GEOD-21266

    Description: ppression or by pharmacological inhibition of the kinase activity. The ERK1-effect on Irs-1 transcription was tested in a reporter system. Results: UDCA-treatment in vivo suppressed potential pro-proliferatory genes including Irs-1 and reduced cell proliferation by more than 30%. In vitro it neutralised the proliferatory signals of IGF-1 and EGF and slowed down the cell cycle. Irs-1 transcription was suppressed due to high ERK1 activation. Both Irs-1 suppression and the persistent high ERK activation inhibited proliferation. Conversely, the decrease of phosphorylation of ERK1 (but not ERK2) or of its expression partially abrogated the inhibitory effects of UDCA. Conclusions: UDCA inhibits proliferation of intestinal epithelial cells by acting upon IGF-1 and EGF pathways and targeting ERK1 and, consequently, Irs-1. The inhibition of these pathways adds a new dimension to the p...

  4. Effect of Ursodeoxycholic acid on gene expression in the intestial epithelium BioProject

    ID: PRJNA126251

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ppression or by pharmacological inhibition of the kinase activity. The ERK1-effect on Irs-1 transcription was tested in a reporter system. Results: UDCA-treatment in vivo suppressed potential pro-proliferatory genes including Irs-1 and reduced cell proliferation by more than 30%. In vitro it neutralised the proliferatory signals of IGF-1 and EGF and slowed down the cell cycle. Irs-1 transcription was suppressed due to high ERK1 activation. Both Irs-1 suppression and the persistent high ERK activation inhibited proliferation. Conversely, the decrease of phosphorylation of ERK1 (but not ERK2) or of its expression partially abrogated the inhibitory effects of UDCA. Conclusions: UDCA inhibits proliferation of intestinal epithelial cells by acting upon IGF-1 and EGF pathways and targeting ERK1 and, consequently, Irs-1. The inhibition of these pathways adds a new dimension to the p...
  5. Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma BioProject

    ID: PRJNA342704

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: el activity of nuclear factor-κB (NF-κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), activator protein-1 (AP-1) and interferon regulatory factor (IRF) transcription factors (TFs) that are physiologically only transiently activated. Here, we demonstrate that inactivation of the putative ubiquitin E3-ligase PDLIM2 contributes to this TF activation. PDLIM2 expression is lost at the mRNA and protein levels in the majority of...
  6. Homo sapiens : WES of patient derived pre-treatment metastatic melanoma on anti-PD-1 antibody treatment BioProject

    ID: PRJNA307199

    Keywords: raw sequence reads

    Access Type: download

  7. ructure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein PDB

    ID: PDB:2NPT

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2), Mitogen-activated protein

  8. ructure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein PDB

    ID: PDB:2O2V

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2), Mitogen-activated protein

  9. CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION PDB

    ID: PDB:2C60

    Description: HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 (E.C.2.7.1.37)...

  10. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:3EQB

    Description: Dual specificity mitogen-activated protein kinase kinase 1 (E.C.2.7.12.2)

  11. Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1 PDB

    ID: PDB:4O91

    Description: Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase

  12. Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase ... PDB

    ID: PDB:1YDS

    Description: C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(METHYLAMINO)ETHYL]...

  13. The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P PDB

    ID: PDB:1Q8U

    Description: cAMP-dependent protein kinase, alpha-catalytic subunit (E.C.2.7.1.37)/cAMP-dependent protein

  14. STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE... PDB

    ID: PDB:1YDT

    Description: C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(4-BROMOCINNAMYLAMI...

  15. The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077) PDB

    ID: PDB:1Q8W

    Description: cAMP-dependent protein kinase, alpha-catalytic subunit (E.C.2.7.1.37)/cAMP-dependent protein

  16. The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632 PDB

    ID: PDB:1Q8T

    Description: cAMP-dependent protein kinase, alpha-catalytic subunit(E.C.2.7.1.37)/cAMP-dependent protein

  17. Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib PDB

    ID: PDB:5HES

    Description: Mitogen-activated protein kinase kinase kinase MLT (E.C.2.7.11.25)

  18. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP PDB

    ID: PDB:3E8N

    Description: Dual specificity mitogen-activated protein kinase kinase 1 (E.C.2.7.12.2)

  19. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P PDB

    ID: PDB:3EQC

    Description: Dual specificity mitogen-activated protein kinase kinase 1 (E.C.2.7.12.2)

  20. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P PDB

    ID: PDB:3EQF

    Description: Dual specificity mitogen-activated protein kinase kinase 1 (E.C.2.7.12.2)


Displaying 20 of 8,398 results for "PKN3"