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Displaying 20 of 906 results for "PIK3CB"
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  1. PIK3CB aCGH Cell Line Results BioProject

    ID: PRJNA123121

    Keywords: Variation

    Access Type: download

  2. PIK3CB aCGH Patient Results BioProject

    ID: PRJNA123119

    Keywords: Variation

    Access Type: download

  3. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [microarray] OmicsDI

    ID: E-GEOD-57718

    Date Released: 03-01-2015

    Description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...

  4. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq] OmicsDI

    ID: E-GEOD-57717

    Date Released: 04-03-2015

    Description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...

  5. JNK3 null vs. wild type hippocampi OmicsDI

    ID: E-GEOD-22267

    Date Released: 05-02-2014

    Description: JNK is a member of the mitogen-activated protein kinase (MAPK) family and there are three genes that encode for JNK1, JNK2 and JNK3 respectively. JNK3 is mainly expressed in the ce...

  6. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq] ArrayExpress

    ID: E-GEOD-57717

    Description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...

  7. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq] BioProject

    ID: PRJNA247831

    Keywords: Epigenomics

    Access Type: download

    dataset.description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...
  8. PK3CB_RAT UniProt:Swiss-Prot

    ID: Q9Z1L0

    Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase

  9. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [microarray] ArrayExpress

    ID: E-GEOD-57718

    Description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...

  10. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [microarray] BioProject

    ID: PRJNA247830

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: igh throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase (PI3K), as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. We validated YAP and TEAD occupancy of a conserved enhancer within the first intron of Pik3cb, and show that this enhancer drives YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the PI3K-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened the YAP mitogenic activity. Reciprocally, Yap loss-of-function impaired heart function and...
  11. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival ArrayExpress

    ID: E-GEOD-57719

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  12. JNK3 null vs. wild type hippocampi ArrayExpress

    ID: E-GEOD-22267

    Description: JNK is a member of the mitogen-activated protein kinase (MAPK) family and there are three genes that encode for JNK1, JNK2 and JNK3 respectively. JNK3 is mainly expressed in the ce...

  13. JNK3 null vs. wild type hippocampi BioProject

    ID: PRJNA128745

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: JNK is a member of the mitogen-activated protein kinase (MAPK) family and there are three genes that encode for JNK1, JNK2 and JNK3 respectively. JNK3 is mainly expressed in the ce...
  14. Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways Figshare

    ID: doi:10.6084/M9.FIGSHARE.1569613.V1

    Release Date: 03-11-2016

    Description:

  15. Additional file 4: of MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3628844_D3

    Release Date: 12-15-2016

    Description: Construction of luciferase reporter vectors.

  16. Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways Figshare

    ID: doi:10.6084/M9.FIGSHARE.1569612.V1

    Release Date: 03-11-2016

    Description:

  17. Simultaneous targeting PI3K/Akt/mTOR and MEK/RAF/ERK pathways results in a synergis6c an6-prolifera6ve effect in an adrenocor6cal carcinoma model Figshare

    ID: doi:10.6084/M9.FIGSHARE.1157871.V2

    Release Date: 01-19-2016

    Description:

  18. BRD4 second bromodomain (BD2) in complex with dual PI3 kinase (PI3K) inhibitor SF2558HA PDB

    ID: PDB:5U2C

    Description: Bromodomain-containing protein 4

  19. STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY PDB

    ID: PDB:1PKS

    Description: PHOSPHATIDYLINOSITOL 3-KINASE (E.C.2.7.1.137) (PI3K) (SH3 DOMAIN) (NMR, MINIMIZED AVERAGE STR...

  20. Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor PDB

    ID: PDB:4ZOP

    Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase


Displaying 20 of 906 results for "PIK3CB"