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Displaying 20 of 43 results for "PIGU"
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  1. Toxoplasma gondii GAB1-2007-GAL-DOM10 : Toxoplasma gondii GAB1-2007-GAL-DOM10 Genome sequencing BioProject

    ID: PRJNA170260

    Keywords: genome sequencing

    Access Type: download

  2. PIGU_RAT UniProt:Swiss-Prot

    ID: Q8CHJ1

    Description: Removed Phosphatidylinositol glycan anchor biosynthesis class <...

  3. PIGU_CRIGR UniProt:Swiss-Prot

    ID: Q8CHJ0

    Description: Removed Phosphatidylinositol glycan anchor biosynthesis class <...

  4. SHP2 SH2 domain in complex with GAB1 peptide PDB

    ID: PDB:4QSY

    Description: Tyrosine-protein phosphatase non-receptor type 11 (E.C.3.1.3.48), GRB2-associated-binding protein 1

  5. PIGW_RAT UniProt:Swiss-Prot

    ID: Q7TSN4

    Description: Phosphatidylinositol-glycan biosynthesis class W protein Lumenal Helical H...

  6. Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... ArrayExpress

    ID: E-GEOD-49896

    Description: P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3’ UTRs having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that may enhance B-cell receptor (BCR) signaling, a putative CLL-growth/survival signal. Also, high-level expression of miR-150 levels was a significant independent predictor of longer treatment-free-survival (TFS) or overall survival (OS), whereas an inverse association was observed for high-level expression of GAB1 or FOXP1 for OS. This study demonstrates that expression of miR-150 can influence the relative expression of GAB1 and FOXP1 and th...

  7. Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... BioProject

    ID: PRJNA215277

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Evolutionary engineering of a wine yeast strain revealed a key role of inositol and mannoprotein metabolism during low-temperature fermentation ArrayExpress

    ID: E-GEOD-67428

    Description: improved fermentation performance. GAA1 encodes a GPI transamidase complex subunit that adds GPI, which is required for inositol synthesis, to newly synthesized proteins, including mannoproteins. Thus we demonstrate the importance of inositol and mannoproteins in yeast adaptation at low temperature and the central role of the GAA1 gene by linking both metabolisms. The first aim of this study was to assess the most competitive strains that grow under wine fermentation conditions at low temperature. To this end, we performed a growth competition assay with 27 commercial wine strains inoculated at equal population size in synthetic grape must. In spite of the economical and industrial importance of these strains, their phenotypic variation in the main enological traits, particularly those related to optimum growth temperature, and their ability to adapt to low temperature fermentation have been poorly investigated. The second goal was to obtain an improved strain to grow and ferment at low temperature by evolutionary engineering. For this purpose, we maintained growth competition in synthetic grape must during 200 generations to select for the mutations that produce phenotypes with improved growth in this medium. One of these evolved cultures was previously treated with ethyl methanesulfonate (EMS) to increase the mutation rate. Finally, we aimed to decipher the molecular basis underlying this improvement by analyzing the genomic and transcriptional differences between the parental strain and the strain evolved at low temperature....

  9. Comparative proteomics and transcriptomics study of signaling network proteins across multiple normal and cancer cell lines BioProject

    ID: PRJNA320318

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: copies per cell, but the adaptors SOS1, SOS2, and GAB1 were found at far lower levels (2,000-5,000 per cell). MAPK signaling showed saturation in all cells between 3,000-10,000 occupied EGFR, consistent with the idea that adaptors limit signaling. Our results suggest that the relative stoichiometry of core MAPK pathway proteins is very similar across different cell types, with cell-specific differences mostly restricted to variable levels of feedback regulators. The low abundance of adaptors relative to the EGFR could be responsible for previous observation of saturable signaling, endocytosis, and high affinity EGFR. Overall design: Cells grown to ~80% confluence were serum starved and processed for both RNA-Seq and proteomics anaysis, using parallel samples. A total of seven samples. RNA was extracted from duplicate 15cm plates and poled before library preparation....
  10. Integrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Ph... ArrayExpress

    ID: E-GEOD-44860

    Description: rresponding changes in gene expression (e.g. ERG, GAB1), suggesting that such genes are inactivated far more frequently than suggested by genetic analyses alone. Collectively, the data support a key role of epigenetic gene regulation in the pathogenesis of ALL, and point towards a scenario where genetic and epigenetic lesions cooperatively determine disease phenotype. 194 samples were analyzed by DNA methylation on the HELP array, including 167 Diagnostic ALL samples, 19 Normal Bone Marrow B cell samples, and 8 Normal T lymphocyte cell samples. There are no replicates....

  11. Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions ... ArrayExpress

    ID: E-GEOD-26281

    Description: rresponding changes in gene expression (e.g. ERG, GAB1), suggesting that such genes are inactivated far more frequently than suggested by genetic analyses alone. Collectively, the data support a key role of epigenetic gene regulation in the pathogenesis of ALL, and point towards a scenario where genetic and epigenetic lesions cooperatively determine disease phenotype. 154 Diagnostic ALL samples were analyzed. There are no replicates. This GEO submission contains only the U133A gene expression profile data described in the study summary....

  12. Integrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Ph... ArrayExpress

    ID: E-GEOD-38295

    Description: rresponding changes in gene expression (e.g. ERG, GAB1), suggesting that such genes are inactivated far more frequently than suggested by genetic analyses alone. Collectively, the data support a key role of epigenetic gene regulation in the pathogenesis of ALL, and point towards a scenario where genetic and epigenetic lesions cooperatively determine disease phenotype. 186 samples were analyzed by DNA methylation on the HELP array, including 167 Diagnostic ALL samples and 19 Normal Bone Marrow B cells. There are no replicates...

  13. Discovery of Non-ETS Gene Fusions in Human Prostate Cancer using Next Generation RNA Sequencing BioProject

    ID: PRJNA74905

    Access Type: download

    dataset.description: of other tumor entities, as well as the oncogene PIGU and the tumor suppressor gene RSRC2... (for more see dbGaP study page.)...
  14. Discovery of Non-ETS Gene Fusions in Human Prostate Cancer using Next Generation RNA Sequencing BioProject

    ID: PRJNA74907

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: of other tumor entities, as well as the oncogene PIGU and the tumor suppressor gene RSRC2... (for more see dbGaP study page.)...
  15. Evolutionary engineering of a wine yeast strain revealed a key role of inositol and mannoprotein metabolism during low-temperature fermentation BioProject

    ID: PRJNA279874

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: improved fermentation performance. GAA1 encodes a GPI transamidase complex subunit that adds GPI, which is required for inositol synthesis, to newly synthesized proteins, including mannoproteins. Thus we demonstrate the importance of inositol and mannoproteins in yeast adaptation at low temperature and the central role of the GAA1 gene by linking both metabolisms. Overall design: The first aim of this study was to assess the most competitive strains that grow under wine fermentation conditions at low temperature. To this end, we performed a growth competition assay with 27 commercial wine strains inoculated at equal population size in synthetic grape must. In spite of the economical and industrial importance of these strains, their phenotypic variation in the main enological traits, particularly those related to optimum growth temperature, and their ability to adapt to low temperature fermentation have been poorly investigated. The second goal was to obtain an improved strain to grow and ferment at low temperature by evolutionary engineering. For this purpose, we maintained growth competition in synthetic grape must during 200 generations to select for the mutations that produce phenotypes with improved growth in this medium. One of these evolved cultures was previously treated with ethyl methanesulfonate (EMS) to increase the mutation rate. Finally, we aimed to decipher the molecular basis underlying this improvement by analyzing the genomic and transcriptional differences between the parental strain and the strain evolved at low temperature....
  16. Discovery of Non-ETS Gene Fusions using RNA Sequencing dbGaP

    ID: phs000310.v1.p1

    Description: of other tumor entities, as well as the oncogene PIGU and the tumor suppressor gene RSRC2. The novel gene fusions are found to be of low frequency but interestingly, the non-ETS fusions were all present in prostate cancer harboring the TMPRSS2-ERG gene fusion. Future work will focus on determining if the ETS rearrangements in prostate cancer are associated or directly predispose to a rearrangement prone phenotype....

    Study Types: Cohort

  17. Discovery of Non-ETS Gene Fusions in Human Prostate Cancer using Next Generation RNA Sequencing OmicsDI

    ID: phs000310.v1.p1

    Date Released:

    Description: of other tumor entities, as well as the oncogene PIGU and the tumor suppressor gene RSRC2. The novel gene fusions are found to be of low frequency but interestingly, the non-ETS fusions were all present in prostate cancer harboring the TMPRSS2-ERG gene fusion. Future work will focus on determining if the ETS rearrangements in prostate cancer are associated or directly predispose to a rearrangement prone phenotype.

    ...

  18. Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... OmicsDI

    ID: E-GEOD-49896

    Date Released: 08-08-2014

    Description: P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3’ UTRs having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that may enhance B-cell receptor (BCR) signaling, a putative CLL-growth/survival signal. Also, high-level expression of miR-150 levels was a significant independent predictor of longer treatment-free-survival (TFS) or overall survival (OS), whereas an inverse association was observed for high-level expression of GAB1 or FOXP1 for OS. This study demonstrates that expression of miR-150 can influence the relative expression of GAB1 and FOXP1 and th...

  19. Evolutionary engineering of a wine yeast strain revealed a key role of inositol and mannoprotein metabolism during low-temperature fermentation OmicsDI

    ID: E-GEOD-67428

    Date Released: 04-05-2015

    Description: improved fermentation performance. GAA1 encodes a GPI transamidase complex subunit that adds GPI, which is required for inositol synthesis, to newly synthesized proteins, including mannoproteins. Thus we demonstrate the importance of inositol and mannoproteins in yeast adaptation at low temperature and the central role of the GAA1 gene by linking both metabolisms. The first aim of this study was to assess the most competitive strains that grow under wine fermentation conditions at low temperature. To this end, we performed a growth competition assay with 27 commercial wine strains inoculated at equal population size in synthetic grape must. In spite of the economical and industrial importance of these strains, their phenotypic variation in the main enological traits, particularly those related to optimum growth temperature, and their ability to adapt to low temperature fermentation have been poorly investigated. The second goal was to obtain an improved strain to grow and ferment at low temperature by evolutionary engineering. For this purpose, we maintained growth competition in synthetic grape must during 200 generations to select for the mutations that produce phenotypes with improved growth in this medium. One of these evolved cultures was previously treated with ethyl methanesulfonate (EMS) to increase the mutation rate. Finally, we aimed to decipher the molecular basis underlying this improvement by analyzing the genomic and transcriptional differences between the parental strain and the strain evolved at low temperature....

  20. Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions ... BioProject

    ID: PRJNA135153

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rresponding changes in gene expression (e.g. ERG, GAB1), suggesting that such genes are inactivated far more frequently than suggested by genetic analyses alone. Collectively, the data support a key role of epigenetic gene regulation in the pathogenesis of ALL, and point towards a scenario where genetic and epigenetic lesions cooperatively determine disease phenotype. Overall design: 154 Diagnostic ALL samples were analyzed. There are no replicates. This GEO submission contains only the U133A gene expression profile data described in the study summary....

Displaying 20 of 43 results for "PIGU"