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Displaying 11 of 11 results for "PF4V1"
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  1. Crystal Structure of CXCL4L1 PDB

    ID: PDB:4HSV

    Description: Platelet factor 4 variant

  2. Gene expression profiling of imatinib-treated and untreated human Hematopoetic progenitors expressing the ETV6-PDGFRB oncogene ArrayExpress

    ID: E-GEOD-28698

    Description: xpression in these cells and in cells treated for 4 h with low dose imatinib (Glivec), a potent PDGFR inhibitor, to switch off TEL-PDGFRb signaling. This experiment was performed in three biological replicates. In each replicate gene expression profiling from CD34+ HSCs expressing TEL-PDGFRb untreated with Glivec was compared to the corresoniding treated condition. Total RNA were extracted from transduced CD34+ cells using Trizol reagent (Invitrogen) and the RNeasy kit (QIAGEN)....

  3. Transcription profiling of mouse 32Dcl3 cell lines expressing oncogenic tyrosine kinases or cells treated with small molecule inhibitors ArrayExpress

    ID: E-GEOD-11794

    Description: lied to 32Dcl3 cells that had been transformed to factor-independent growth by these respective oncogenic alleles. Experiment Overall Design: In our microarray study, we have total 22 samples from four different cell lines expressing BCR-ABL, TEL-ABL, FLT3-ITD or TEL-PDGF-betaR. Each cell line was treated with specific small molecule inhibitors for 4 hours, then RNA was extracted and cRNA was hybridized to Affymetrix U74 oligonucleotide arrays. Untreated cells or cells treated with unrelated inhibitors were used as controls or references. We have...

  4. The developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors (SNEL iPSC and H2A.X deposition pattern) ArrayExpress

    ID: E-GEOD-55731

    Description: SCs. Compare H2A.X deposition pattern of the OSKM 4-factor iPS cell lines (4N-), SNEL 4-factor iPS cell lines (4N+) with ChIP-Seq. The same background ES cell line as the control line....

  5. NHLBI STAMPEED : SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data, GWAS in NHLBI cohorts BioProject

    ID: PRJNA66039

    Access Type: download

    dataset.description: STAMPEED is comprised of the following studies: [1] A Genome-wide Association Study for Early-Onset Myocardial Infarction (STAMPEED: MIGen) GWAS of early onset MI and related risk factors in 6,042 Caucasian cases and controls (MIGen). Data are from multiple North American and European studies. [2] Genome-Wide Association Studies of Asthma in Populations of African Descent GWAS of asthma in cases and controls of African ancestry in Barbados (GRAAD study). Approximately 2,000 individuals have genotype and phenotype available. [3] Genome-Wide Association of Platelet Phenotypes GWAS of platelet aggregation phenotypes in response to aspirin therapy. Approximately 3,358 family members of European and African ancestry from the G...
  6. Data from: Important impacts of tissue selection and lipid extraction on ecological parameters derived from stable isotope ratios Dryad

    DateIssued: 10-08-2013

    Description: 1. The nitrogen (δ15N) and carbon (δ13C) isotope ratios of animal tissues can help identify the composition of diets and open up ...

  7. Single-cell chromatin accessibility data using scATAC-seq ArrayExpress

    ID: E-GEOD-65360

    Description: eted perturbations of cell cycle or transcription factor signaling evoke stimulus-specific changes in this observed variability. The pattern of accessibility variation in cis across the genome recapitulates chromosome topological domains de novo, linking single-cell accessibility variation to three-dimensional genome organization. All together, single-cell analysis of DNA accessibility provides new insight into cellular variation of the “regulome.” Profiles of single cell epigenomes, assayed using scATAC-seq, across 8 cell types and 4 targeted cell manipulations. The complete data set contains a total of 1,632 assayed wells....

  8. Glyco gene profiling of two Hela cell lines to help identify NKp30L expressed on tumoral cells ArrayExpress

    ID: E-GEOD-29930

    Description: NKp30 is one of the first NK-specific triggering receptor involved in tumour cell lysis to be identified. It is part of the so-called Natural Cytotoxi...

    datasetDistributions.accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-29930/E-GEOD-29930.raw.1.zip
  9. Gene expression change in natural allotetraploid, A.suecica BioProject

    ID: PRJNA109997

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nt (plant species, T), array (A) and dye (D); i = 1,…, 31818; j = 1, 2; k = 1, 2, 3, 4;l = 1,2; µ represents the overall mean. The interaction terms, G*T, G*A, G*D, and G*T*D mean gene-by-species, gene-by-array, gene-by-dye and gene-by-species-by-dye. ɛijkl represents random error. To test difference of mRNA expression between A.suecica and mid-parent value (MPV), t-tests were employed for individual genes (pergene-variance). The null hypothesis, H0: TA.suecica + (G*T)i,A.suecica = TMPV + (G*T)i,MPV was examined by p-value. Overall type I error rate of multiple testing was controlled to be below 0.05 employing the false discovery rate of Benjamini and Hotchberg....
  10. Transcription profiling of rat smooth muscle cells modulated by rapamycin and paclitaxel ArrayExpress

    ID: E-GEOD-5337

    Description: g changes in the transcription of VEGF, PDGF, JAG-1 and their respective receptors, suggesting an important effect on paracrine and autocrine response to mitogens. However, the gene expression signatures elicited by paclitaxel showed little variation under different cell culture conditions. In contrast, these gene expression responses to rapamycin varied considerably depending on the glycemic conditions of culture, and rapamycin had a dramatic dose- and metabolic status- dependent effect on the transcription of key members of the AKT signaling axis, providing a transcriptional explanation for the paradoxical proliferative effect of rapamycin at low dose in the setting of high glucose concentrations and insulin resistance. Conclusions: Gene expression signatures for drugs eluted from coronary stents vary dramatically in ways that correlate with known differences in biological activities of these drugs. Gene expression profiling may provide a useful preclinical method to characterize the activities of candidate drugs for stent impregnation and to understand their biological activities. Experiment Overall Design: Reagents: Paclitaxel, rapamycin, insulin, dimethyl sulfoxide and glucose were obtained from Sigma-Aldrich (St. Loius, MO, USA). Dulbecco’s Minimum Essential Medium (DMEM), Trypsin/ EDTA, antibiotics/antimycotics, tissue cu...

  11. Gene Expression Profiling In Rat Smooth Muscle Cells Modulated by Rapamycin and Paclitaxel. BioProject

    ID: PRJNA96357

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g changes in the transcription of VEGF, PDGF, JAG-1 and their respective receptors, suggesting an important effect on paracrine and autocrine response to mitogens. However, the gene expression signatures elicited by paclitaxel showed little variation under different cell culture conditions. In contrast, these gene expression responses to rapamycin varied considerably depending on the glycemic conditions of culture, and rapamycin had a dramatic dose- and metabolic status- dependent effect on the transcription of key members of the AKT signaling axis, providing a transcriptional explanation for the paradoxical proliferative effect of rapamycin at low dose in the setting of high glucose concentrations and insulin resistance. Conclusions: Gene expression signatures for drugs eluted from coronary stents vary dramatically in ways that correlate with known differences in biological activities of these drugs. Gene expression profiling may provide a useful preclinical method to characterize the activities of candidate drugs for stent impregnation and to understand their biological activities. Keywords: Cardiovascular disease, drug eluting stent, vascular smooth muscle, rapamycin, paclitaxel Overall design: Reagents: Paclitaxel, rapamycin, insulin, dimethyl sulfoxide and glucose were obtained from Sigma-Aldrich (St. Loius, MO, USA). Dulbecc...

Displaying 11 of 11 results for "PF4V1"