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Displaying 20 of 41 results for "PENK"
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  1. PENK_CAVPO UniProt:Swiss-Prot

    ID: P47969

    Description: Synenkephalin Met-enkephalin Met-enkephalin PENK(114-133) Met-enkephalin PENK(143-184) Met-enkephalin-Arg-Gly-Leu Met-enkephalin Leu-enkephalin

  2. Data from: Penk et al 2016 Journal of Animal Ecology Figshare

    ID: doi:10.6084/M9.FIGSHARE.1612177

    Release Date: 11-25-2015

    Description:

  3. Data from: Penk et al 2016 Journal of Animal Ecology Figshare

    ID: doi:10.6084/M9.FIGSHARE.1612177.V1

    Release Date: 01-20-2016

    Description:

  4. Data from: Penk et al 2015 Journal of Animal Ecology Figshare

    ID: doi:10.6084/M9.FIGSHARE.1418253

    Release Date: 06-08-2015

    Description:

  5. Data from: Penk et al 2015 Journal of Animal Ecology Figshare

    ID: doi:10.6084/M9.FIGSHARE.1418253.V1

    Release Date: 01-19-2016

    Description:

  6. The molecular basis of analgesia in congenital insensitivity to pain associated with loss of Nav1.7 function ArrayExpress

    ID: E-GEOD-61373

    Description: as well as upregulation of enkephalin precursor PENK mRNA and down regulation of CEACAM10 mRNA, a protein involved in noxious thermosensation. PENK mRNA is transcriptionally upregulated in Nav1.7 null mutant female sensory neurons, resulting in increased enkephalin expression in the dorsal horn of the spinal cord. PENK expression is down-regulated by addition of the sodium ionophore monensin, suggesting that sodium may play a role as a second messenger. Application of the opioid antagonist naloxone strongly enhances noxious peripheral input into the spinal cord, and dramatically reduces analgesia in both male and female Nav1.7 null mutant mice, as well as in human Nav1.7 null mutants. These data show that loss of Nav1.7 expression increase...

  7. Gene copy number variations associated with patient survival in uveal melanoma ArrayExpress

    ID: E-GEOD-37259

    Description: nversely, those patients with an amplification of PENK (8q) showed reduced survival (log rank p<0.001). CNKSR3, RIPK1 and PENK are novel candidate metastasis regulatory genes in uveal melanoma. This is the first report of amplification of a specific gene on 6p that is associated with improved uveal melanoma patient survival and suggests that the development of uveal melanomas with a propensity to metastasise may be limited by genes on 6p. 58 samples in total. Ten disomy 3 with long-term survival. Fifteen disomy 3 with metastasising. Seventeen monosomy 3 with long-term survival. Sixteen monosomy 3 metastasising....

  8. The molecular basis of analgesia in congenital insensitivity to pain associated with loss of Nav1.7 function BioProject

    ID: PRJNA260894

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: as well as upregulation of enkephalin precursor PENK mRNA and down regulation of CEACAM10 mRNA, a protein involved in noxious thermosensation. PENK mRNA is transcriptionally upregulated in Nav1.7 null mutant female sensory neurons, resulting in increased enkephalin expression in the dorsal horn of the spinal cord. PENK expression is down-regulated by addition of the sodium ionophore monensin, suggesting that sodium may play a role as a second messenger. Application of the opioid antagonist naloxone strongly enhances noxious peripheral input into the spinal cord, and dramatically reduces analgesia in both male and female Nav1.7 null mutant mice, as well as in human Nav1.7 null mutants. These data show that loss of Nav1.7 expression increases...
  9. A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis BioProject

    ID: PRJNA197502

    Keywords: Epigenomics

    Access Type: download

    dataset.description: alyzed (p<0.01). Of these we identified GSTM2 and PENK as novel hypermethylated genes in prostate cancer that were simultaneously methylated in 40.9% of the tumors analyzed. We also identified panels of genes more frequently methylated in tumor samples with clinico-pathological indicators of poor prognosis: high Gleason score, elevated Ki-67 or advanced disease. Of these, we found that simultaneous hypermethylation of CFTR and HTR1B is common in patients with high Gleason score and high ki-67 levels and might signal the population at higher risk of therapeutic failure. DNA hypermethylation profile was associated with cancer-specific mortality (log-rank, p=0.007) and biochemical recurrence-free survival (log-rank, p=0.0008). In conclusion, our data strongly indicate that epigenetic silencing of GSTM2 and PENK is a common event in prostate cancer that could be used as a molecular marker for prostate cancer diagnosis. In addition, simultaneous HTR1B and CFTR hypermethylation could help discrim...
  10. Breast Brain Metastasis, Non-Neoplastic Brain, and Non-Neoplastic Breast Gene Expression ArrayExpress

    ID: E-GEOD-52604

    Description: ion due to hypermethylation and downregulation of PENK, EDN3, and ITGAM. Hypomethylation and upregulation of KRT8 likely affects adhesion and permeability. Genomic and epigenomic profiling of breast CNS metastasis has provided insight into the somatic events underlying this disease, which have potential in forming the basis of future therapeutic strategies. Three sample-types: 35 Breast Brain Metastasis samples, 10 Non-Neoplastic Brain samples, and 10 Non-Neoplastic Breast samples....

  11. Aging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (DNA Methylation) ArrayExpress

    ID: E-GEOD-49064

    Description: netic biomarkers of aging including ELOVL2, FHL2, PENK, and KLF14 was confirmed in our study, but these genes did not display an age-related change in gene expression in PBMCs. Bioinformatic analysis revealed that differentially methylated genes that lack an age-related expression change predominantly represent genes involved in carcinogenesis and developmental processes, and expression of most of these genes were silenced in PBMCs. No changes in DNA methylation were found in genes displaying transiently induced changes in gene expression. In conclusion, aging-induced differential methylation often targets developmental genes and occurs mostly without change in gene expression. Peripheral blood mononuclear cells were isolated from 10 volunteers (5 young 5 old), treated with the synthetic PPARalpha agonists WY14,643 or control for 13 hrs, and subjected to genome-wide DNA methylation and gene expression analysis. This entry contains the DNA methylation data....

  12. The molecular basis of analgesia in congenital insensitivity to pain associated with loss of Nav1.7 function OmicsDI

    ID: E-GEOD-61373

    Date Released: 08-05-2015

    Description: as well as upregulation of enkephalin precursor PENK mRNA and down regulation of CEACAM10 mRNA, a protein involved in noxious thermosensation. PENK mRNA is transcriptionally upregulated in Nav1.7 null mutant female sensory neurons, resulting in increased enkephalin expression in the dorsal horn of the spinal cord. PENK expression is down-regulated by addition of the sodium ionophore monensin, suggesting that sodium may play a role as a second messenger. Application of the opioid antagonist naloxone strongly enhances noxious peripheral input into the spinal cord, and dramatically reduces analgesia in both male and female Nav1.7 null mutant mice, as well as in human Nav1.7 null mutants. These data show that loss of Nav1.7 expression increase...

  13. PENKA_XENLA UniProt:Swiss-Prot

    ID: P01212

    Description: Synenkephalin Met-enkephalin Met-enkephalin Met-enkephalin Met-enkephalin-Arg-Gly-Tyr Met-enkephalin Met-enkephalin Met-enkephalin-Arg-Phe

    gene.name: penk-a
  14. PENKB_XENLA UniProt:Swiss-Prot

    ID: P07194

    Description: Synenkephalin Met-enkephalin Met-enkephalin Met-enkephalin Met-enkephalin-Arg-Gly-Tyr Met-enkephalin Met-enkephalin Met-enkephalin-Arg-Phe

    gene.name: penk-b
  15. PENK_FELCA UniProt:Swiss-Prot

    ID: Q28409

    Description: Synenkephalin Met-enkephalin Met-enkephalin Met-enkephalin Met-enkephalin Leu-enkephalin Phosphoserine

    gene.name: PENK
  16. Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells ArrayExpress

    ID: E-GEOD-70175

    Description: y down regulated in GBMs such as SPINT2, NEFM and PENK. Forced re-expression of SPINT2 reduced glioma cell proliferative capacity, anchorage independent growth, cell motility, and tumor sphere formation in vitro. The results from this study demonstrate that GSCs possess unique epigenetic signatures that may play important roles in the pathogenesis of GBM. The reduced representation bisulfite sequencing (RRBS) approach (Meissner et al., 2008) was used to generate genome-wide single-base resolution CpG methylation profiles of three primary GBMs (1063T, 1133T, and 1142T) and three GSC lines (1063S, 1133S, 1142S) derived from these primary GBM tumors. The NSC line and the normal brain (NB) tissue sample were used as controls for comparison purposes. In addition, we analyzed three GBM xenograft tumor tissue samples (Mayo22, Mayo39, Mayo59) developed by Dr. Jann N. Sarkaria of Mayo Clinic....

  17. Aging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression) ArrayExpress

    ID: E-GEOD-49058

    Description: netic biomarkers of aging including ELOVL2, FHL2, PENK, and KLF14 was confirmed in our study, but these genes did not display an age-related change in gene expression in PBMCs. Bioinformatic analysis revealed that differentially methylated genes that lack an age-related expression change predominantly represent genes involved in carcinogenesis and developmental processes, and expression of most of these genes were silenced in PBMCs. No changes in DNA methylation were found in genes displaying transiently induced changes in gene expression. In conclusion, aging-induced differential methylation often targets developmental genes and occurs mostly without change in gene expression. Peripheral blood mononuclear cells were isolated from 10 volunteers (5 young 5 old), treated with the synthetic PPARalpha agonists WY14,643 or control for 13 hrs, and subjected to genome-wide DNA methylation and gene expression analysis. This entry contains the gene expression data....

  18. Gene copy number variations associated with patient survival in uveal melanoma BioProject

    ID: PRJNA159145

    Keywords: Variation

    Access Type: download

    dataset.description: nversely, those patients with an amplification of PENK (8q) showed reduced survival (log rank p<0.001). CNKSR3, RIPK1 and PENK are novel candidate metastasis regulatory genes in uveal melanoma. This is the first report of amplification of a specific gene on 6p that is associated with improved uveal melanoma patient survival and suggests that the development of uveal melanomas with a propensity to metastasise may be limited by genes on 6p. Overall design: 58 samples in total. Ten disomy 3 with long-term survival. Fifteen disomy 3 with metastasising. Seventeen monosomy 3 with long-term survival. Sixteen monosomy 3 metastasising....
  19. Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats BioProject

    ID: PRJNA341459

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: asal ganglia. These genes included proenkephalin (PENK) and prodynorphin (PDYN), among others. Because PDYN and PENK are expressed in dopamine D1- and D2-containing NAc neurons, respectively, these findings suggest that mechanisms that impact both cell types may play a role in the regulation of compulsive methamphetamine taking by rats. Overall design: Six rats from each of the 3 groups including control, shock resistant, and shock sensitive were selected based on RNA quality and integrity for RNA extraction and hybridization on Affymetrix microarrays....
  20. Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells BioProject

    ID: PRJNA287801

    Keywords: Epigenomics

    Access Type: download

    dataset.description: y down regulated in GBMs such as SPINT2, NEFM and PENK. Forced re-expression of SPINT2 reduced glioma cell proliferative capacity, anchorage independent growth, cell motility, and tumor sphere formation in vitro. The results from this study demonstrate that GSCs possess unique epigenetic signatures that may play important roles in the pathogenesis of GBM. Overall design: The reduced representation bisulfite sequencing (RRBS) approach (Meissner et al., 2008) was used to generate genome-wide single-base resolution CpG methylation profiles of three primary GBMs (1063T, 1133T, and 1142T) and three GSC lines (1063S, 1133S, 1142S) derived from these primary GBM tumors. The NSC line and the normal brain (NB) tissue sample were used as controls for comparison purposes. In addition, we analyzed three GBM xenograft tumor tissue samples (Mayo22, Mayo39, Mayo59) developed by Dr. Jann N. Sarkaria of Mayo Clinic....

Displaying 20 of 41 results for "PENK"