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Displaying 18 of 18 results for "PCGF2"
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  1. The Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms BioProject

    ID: PRJNA281091

    Keywords: Other

    Access Type: download

  2. The Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms OmicsDI

    ID: E-GEOD-67868

    Date Released: 09-13-2015

    Description: ntiation protocols, we have elucidated a role for Pcgf2/Mel18 in specifically regulating mesoderm differentiation. Mechanistically, during early cardiac mesoderm differentiation, Pcgf2/Mel18 functions as a classical Polycomb protein by repressing pluripotency, lineage specification, late cardiac differentiation and negative regulators of the BMP pathway, yet Pcgf2/Mel18 also positively regulates the expression of key mesoderm transcription factors, revealing a novel function of Pcgf2/Mel18 in gene activation during cardiac differentiation. Mel18 depletion results in an unbalance of path...

  3. The Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms ArrayExpress

    ID: E-GEOD-67868

    Description: ntiation protocols, we have elucidated a role for Pcgf2/Mel18 in specifically regulating mesoderm differentiation. Mechanistically, during early cardiac mesoderm differentiation, Pcgf2/Mel18 functions as a classical Polycomb protein by repressing pluripotency, lineage specification, late cardiac differentiation and negative regulators of the BMP pathway, yet Pcgf2/Mel18 also positively regulates the expression of key mesoderm transcription factors, revealing a novel function of Pcgf2/Mel18 in gene activation during cardiac differentiation. Mel18 depletion results in an unbalance of path...

  4. Non-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis ArrayExpress

    ID: E-GEOD-54580

    Description: GFP-fusion vectors encoding GFP-CBX2, PCGF1-GPF, PCGF2-GFP, PCGF4-GFP, GFP-RING1A or GFP-RING1B. K562 cells expressing GFP-fusions at relatively low levels were sorted and expanded and subsequently crosslinked. ChIP reactions were performed using the following antibodies: anti-GFP (ab290, Abcam), anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), and anti-KDM2B (ab137547, Abcam). Furthermore, ChIP reactions were performed using primary AML CD34+ and Peripheral Blood (PB) CD34+ cells using anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), anti-KDM2B (ab137547, Abcam)....

  5. The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation ArrayExpress

    ID: E-GEOD-74330

    Description: zation. ChIP-seq samples for Suz12, Ezh2, Ring1b, Pcgf2, and inputs from mouse embryonic stems cells (mES) and neural progenitor cells (NPC) as well as NPC histone H3K4me1 ChIP-seq....

  6. Transcription profiling by array of human breast tumors and adjacent cancer-free tissue to study Bmi-1 and Mel-18 expression ArrayExpress

    ID: E-MTAB-271

    Description: A total of 79 breast tumors (71 malignant tumors, 6 fibroadenomas, and 2 DCIS) were studied and compared to the reduction mammoplastic specimens of 12...

  7. The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation BioProject

    ID: PRJNA299693

    Keywords: Epigenomics

    Access Type: download

    dataset.description: design: ChIP-seq samples for Suz12, Ezh2, Ring1b, Pcgf2, and inputs from mouse embryonic stems cells (mES) and neural progenitor cells (NPC) as well as NPC histone H3K4me1 ChIP-seq....
  8. Non-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis BioProject

    ID: PRJNA237059

    Keywords: Epigenomics

    Access Type: download

    dataset.description: GFP-fusion vectors encoding GFP-CBX2, PCGF1-GPF, PCGF2-GFP, PCGF4-GFP, GFP-RING1A or GFP-RING1B. K562 cells expressing GFP-fusions at relatively low levels were sorted and expanded and subsequently crosslinked. ChIP reactions were performed using the following antibodies: anti-GFP (ab290, Abcam), anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), and anti-KDM2B (ab137547, Abcam). Furthermore, ChIP reactions were performed using primary AML CD34+ and Peripheral Blood (PB) CD34+ cells using anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), anti-KDM2B (ab137547, Abcam)....
  9. The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation OmicsDI

    ID: E-GEOD-74330

    Date Released: 05-22-2016

    Description: zation. ChIP-seq samples for Suz12, Ezh2, Ring1b, Pcgf2, and inputs from mouse embryonic stems cells (mES) and neural progenitor cells (NPC) as well as NPC histone H3K4me1 ChIP-seq....

  10. Effect of MEL-18 knockdown on estrogen-sensitive MCF7 breast cancer cells ArrayExpress

    ID: E-GEOD-64716

    Description: Gene expression analysis of MEL-18-silenced MCF7 cell lines. MEL-18 is a component of the polycomb repressive complex (PRC)-1, which is a critical epi...

  11. Role of Polycomb group proteins in the DNA damage response – a reassessment ArrayExpress

    ID: E-GEOD-55605

    Description: We have investigated whether components of Polycomb repressive complex 1 (PRC1) are recruited to double-strand breaks (DSBs) generated by inducible ex...

  12. Non-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis OmicsDI

    ID: E-GEOD-54580

    Date Released: 11-28-2015

    Description: GFP-fusion vectors encoding GFP-CBX2, PCGF1-GPF, PCGF2-GFP, PCGF4-GFP, GFP-RING1A or GFP-RING1B. K562 cells expressing GFP-fusions at relatively low levels were sorted and expanded and subsequently crosslinked. ChIP reactions were performed using the following antibodies: anti-GFP (ab290, Abcam), anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), and anti-KDM2B (ab137547, Abcam). Furthermore, ChIP reactions were performed using primary AML CD34+ and Peripheral Blood (PB) CD34+ cells using anti-H3K27me3 (07-449, Millipore), anti-H3K4me3 (ab8580, Abcam), anti-H2AK119ub (D27C4, Cell Signaling Technology), anti-KDM2B (ab137547, Abcam)....

  13. Transcription profiling by array of human medulloblastoma cells after knock-down of Bmi-1 and Mel-18 ArrayExpress

    ID: E-GEOD-7578

    Description: Bmi-1 and Mel-18 are close structural homologues that belong to the polycomb group (PcG) of transcriptional regulators of homeotic gene expression in ...

  14. Effect of MEL-18 knockdown on estrogen-sensitive MCF7 breast cancer cells BioProject

    ID: PRJNA271730

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Role of Polycomb group proteins in the DNA damage response – a reassessment BioProject

    ID: PRJNA240224

    Keywords: Epigenomics

    Access Type: download

  16. shRNA-mediated knock down of Bmi-1 and Mel-18 in medulloblastoma cells BioProject

    ID: PRJNA100319

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Lasting effects of early exposure to temperature on the gonadal transcriptome at the time of sex differentiation in the European sea bass, a fish with... BioProject

    ID: PRJNA227361

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: atory mechanisms (hdac11, dicer1, ehmt2, jarid2a, pcgf2, suz12, mettl22). Conclusions: Taken together, the results of this study contribute to the understanding of how the early environment sets permanent changes that result in long-lasting consequences, in this case in the sexual phenotype. Results also show the usefulness of comparing the effects of heat on the behavior of cognate genes related to sex differentiation as well as that of genes involved in establishing and maintaining cell identity through epigenetic mechanisms. Overall design: Whole gonad transcriptome analysis from 10 individuals: 5 individuals early reared at a low temperature (15°C) and 5 individuals early reared at high temperature (21°C)....
  18. shRNA-mediated knock down of Bmi-1 and Mel-18 in medulloblastoma cells GEMMA

    ID: 534

    Keywords: functional genomics

    Description: Bmi-1 and Mel-18 are close structural homologues that belong to the polycomb group (PcG) of transcriptional regulators of homeotic gene expression in ...


Displaying 18 of 18 results for "PCGF2"