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Displaying 20 of 24 results for "PCDH8"
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  1. Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma ArrayExpress

    ID: E-GEOD-19243

    Description: ntified four hypermethylated genes CDKN2B, MLF-1, PCDH8, HOXD8 and four hypomethylated genes CD37, HDAC1, NOTCH1 and CDK5 where aberrant methylation was associated with inverse changes in mRNA levels. MassArray Epityper analysis confirmed the presence of differential methylation at the promoter region of these genes. Immunohistochemical analysis of an independent cohort of 14 MCL patient samples, confirmed CD37 surface expression in 93% of patients, validating its selection as a target for MCL therapy. Treatment of MCL cell lines with a novel small modular immunopharmaceutical(CD37-SMIP) resulted in sign...

  2. STRUCTURE OF THE P PILUS USHER (PAPC) TRANSLOCATION PORE PDB

    ID: PDB:2VQI

    Description: OUTER MEMBRANE USHER PROTEIN PAPC

  3. A mesodermal gene regulatory network directed by zebrafish No tail ArrayExpress

    ID: E-GEOD-12331

    Description: er studies (wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. We also included in this design 502 intensity control probes. Finally there are 2,256 controls added by Agilent. The final design contained 378,002 probes, including 365,537 experimental probes divided between nine microarray slides: slides 1-8 contained 40,616 experimental probes and slide 9 contained 40, 609. Further information on design and manufacture of the microarrays can be found on the Agilent Technologies website (www.agilent.com)....

  4. A network of transcriptional repression specifies muscle fibre type in the zebrafish embryo ArrayExpress

    ID: E-GEOD-10883

    Description: ylz2, myhz2, wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. Finally on each array there are 1804 controls added by Agilent. The final design contained 352,490 probes divided between two microarray slides. Further information on design and manufacture of the microarrays can be found at the Agilent Technologies website....

  5. Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma OmicsDI

    ID: E-GEOD-19243

    Date Released: 05-01-2014

    Description: ntified four hypermethylated genes CDKN2B, MLF-1, PCDH8, HOXD8 and four hypomethylated genes CD37, HDAC1, NOTCH1 and CDK5 where aberrant methylation was associated with inverse changes in mRNA levels. MassArray Epityper analysis confirmed the presence of differential methylation at the promoter region of these genes. Immunohistochemical analysis of an independent cohort of 14 MCL patient samples, confirmed CD37 surface expression in 93% of patients, validating its selection as a target for MCL therapy. Treatment of MCL cell lines with a novel small modular immunopharmaceutical(CD37-SMIP) resulted in sign...

  6. Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function ArrayExpress

    ID: E-GEOD-35709

    Description: Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycerol-2-phosphatidylcholine (PAPC), referred to as OxPAPC, accumulate in atherosclerotic lesion...

  7. Hydrogen modulates signal transduction through manipulating oxidized phospholipid mediators ArrayExpress

    ID: E-GEOD-62434

    Description: We have previously demonstrated that molecular hydrogen (H2) neutralizes hydroxyl radical (•OH) in cultured-cells and protects cells and tissues aga...

  8. A network of transcriptional repression specifies muscle fibre type in the zebrafish embryo BioProject

    ID: PRJNA107277

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ylz2, myhz2, wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. Finally on each array there are 1804 controls added by Agilent. The final design contained 352,490 probes divided between two microarray slides. Further information on design and manufacture of the microarrays can be found at the Agilent Technologies website....
  9. Hydrogen modulates signal transduction through manipulating oxidized phospholipid mediators BioProject

    ID: PRJNA264091

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Zebrafish promoter microarrays identify actively transcribed embryonic genes ArrayExpress

    ID: E-GEOD-4863

    Description: ve controls (wnt11, flh, vent, msgn1, myod, fgf8, pcdh8). Probes designed against these promoters, which flank from 3-4kb around each TSS, are arrayed 2-4 times on each slide. Since these genes are expressed at gastrula stages to varying degrees, they also serve as a positive controls in this study. Finally there are 2256 controls added by Agilent and a variable number of blank spots. These probes were divided between two microarray slides each with 44,290 features. We refer to these two microarray slides as the ‘proximal promoter set’. A proximal promoter set based on these designs as well as an expanded set of 9 slides which contain regions from –9kb to + 3kb relative to the TSS, are available by contacting Agilent (www.agilent.com) or by downloading the design files from for self-manufacture....

  11. Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma BioProject

    ID: PRJNA120777

    Keywords: Other

    Access Type: download

    dataset.description: ntified four hypermethylated genes CDKN2B, MLF-1, PCDH8, HOXD8 and four hypomethylated genes CD37, HDAC1, NOTCH1 and CDK5 where aberrant methylation was associated with inverse changes in mRNA levels. MassArray Epityper analysis confirmed the presence of differential methylation at the promoter region of these genes. Immunohistochemical analysis of an independent cohort of 14 MCL patient samples, confirmed CD37 surface expression in 93% of patients, validating its selection as a target for MCL therapy. Treatment of MCL cell lines with a novel small modular immunopharmaceutical(CD37-SMIP) resulted in sign...
  12. A mesodermal gene regulatory network directed by zebrafish No tail BioProject

    ID: PRJNA113221

    Keywords: Epigenomics

    Access Type: download

    dataset.description: er studies (wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. We also included in this design 502 intensity control probes. Finally there are 2,256 controls added by Agilent. The final design contained 378,002 probes, including 365,537 experimental probes divided between nine microarray slides: slides 1-8 contained 40,616 experimental probes and slide 9 contained 40, 609. Further information on design and manufacture of the microarrays can be found on the Agilent Technologies website (www.agilent.com)....
  13. Genome-wide DNA methylation profiles of human hepatocellular carcinoma OmicsDI

    ID: E-GEOD-44970

    Date Released: 06-02-2014

    Description: (p16, SOCS2, SFRP5, RBP1) and potential (SRD5A2, PCDH8, IGF-1R, UCHL1) TSGs, and the miR-10a. 133 genes were specifically hypermethylated in HCC. Among them the transcription factors GATA2, DLX1, and KLF14, all significantly inversely correlated to gene expression (p=0.003, p=0.03, and p=0.007, respectively). The methylation status of SOCS2 (p=0.025) and DLX1 (p=0.025) was significantly correlated to phosphorylation of IGFR1. Samples with RBP1 hypermethylation showed significantly higher AFP serum levels (p=0.018). Conclusion: Whole genome methylation analysis markedly classifies normal, cirrhotic and HCC samples. 8 TSGs play a key role in this stepwise progression of hypermethylation in the development of HCC and could be a promising point of action in anticancer therapy. Genomic DNA extracted from fresh frozen tissue specimens and cell lines was hybridized to genome-wide mthylation beadarray after bisulphite treatment. Keywords: DNA methylation, hepatocellular carcinoma, tissue, cell line...

  14. Zebrafish promoter microarrays identify actively transcribed embryonic genes BioProject

    ID: PRJNA95749

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ve controls (wnt11, flh, vent, msgn1, myod, fgf8, pcdh8). Probes designed against these promoters, which flank from 3-4kb around each TSS, are arrayed 2-4 times on each slide. Since these genes are expressed at gastrula stages to varying degrees, they also serve as a positive controls in this study. Finally there are 2256 controls added by Agilent and a variable number of blank spots. These probes were divided between two microarray slides each with 44,290 features. We refer to these two microarray slides as the ‘proximal promoter set’. A proximal promoter set based on these designs as well as an expanded set of 9 slides which contain regions from –9kb to + 3kb relative to the TSS, are available by contacting Agilent (www.agilent.com) or by downloading the design files from http://jura.wi.mit.edu/bioc/gbell/zfish_chip/ for self-manufacture....
  15. Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids ArrayExpress

    ID: E-GEOD-29903

    Description: Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In...

  16. Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function BioProject

    ID: PRJNA152049

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Genome-wide DNA methylation profiles of human hepatocellular carcinoma ArrayExpress

    ID: E-GEOD-44970

    Description: (p16, SOCS2, SFRP5, RBP1) and potential (SRD5A2, PCDH8, IGF-1R, UCHL1) TSGs, and the miR-10a. 133 genes were specifically hypermethylated in HCC. Among them the transcription factors GATA2, DLX1, and KLF14, all significantly inversely correlated to gene expression (p=0.003, p=0.03, and p=0.007, respectively). The methylation status of SOCS2 (p=0.025) and DLX1 (p=0.025) was significantly correlated to phosphorylation of IGFR1. Samples with RBP1 hypermethylation showed significantly higher AFP serum levels (p=0.018). Conclusion: Whole genome methylation analysis markedly classifies normal, cirrhotic and HCC samples. 8 TSGs play a key role in this stepwise progression of hypermethylation in the development of HCC and could be a promising point of action in anticancer therapy. Genomic DNA extracted from fresh frozen tissue specimens and cell lines was hybridized to genome-wide mthylation beadarray after bisulphite treatment. Keywords: DNA methylation, hepatocellular carcinoma, tissue, cell line...

  18. A mesodermal gene regulatory network directed by zebrafish No tail OmicsDI

    ID: E-GEOD-12331

    Date Released: 05-03-2014

    Description: er studies (wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. We also included in this design 502 intensity control probes. Finally there are 2,256 controls added by Agilent. The final design contained 378,002 probes, including 365,537 experimental probes divided between nine microarray slides: slides 1-8 contained 40,616 experimental probes and slide 9 contained 40, 609. Further information on design and manufacture of the microarrays can be found on the Agilent Technologies website (www.agilent.com)....

  19. A network of transcriptional repression specifies muscle fibre type in the zebrafish embryo OmicsDI

    ID: E-GEOD-10883

    Date Released: 05-01-2014

    Description: ylz2, myhz2, wnt11, flh, vent, msgn1, myod, fgf8, pcdh8) and these probes are arrayed on both slides slide. Finally on each array there are 1804 controls added by Agilent. The final design contained 352,490 probes divided between two microarray slides. Further information on design and manufacture of the microarrays can be found at the Agilent Technologies website....

  20. Transcription profiling of UV- or oxidized lipid treated dermal skin fibroblasts ArrayExpress

    ID: E-GEOD-13606

    Description: Long wavelength Ultraviolet (UVA-1) radiation causes oxidative stress that leads to the formation of noxious substances within the skin. As a defensiv...


Displaying 20 of 24 results for "PCDH8"