P2RY12 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 21 results for "P2RY12"
i
  1. Crystal structure of P2Y12 receptor in complex with 2MeSADP PDB

    ID: PDB:4PXZ

    Description: P2Y purinoceptor 12, Soluble cytochrome b562

  2. Crystal structure of P2Y12 receptor in complex with 2MeSATP PDB

    ID: PDB:4PY0

    Description: P2Y purinoceptor 12, Soluble cytochrome b562

  3. Structure of the human P2Y12 receptor in complex with an antithrombotic drug PDB

    ID: PDB:4NTJ

    Description: P2Y purinoceptor 12, Soluble cytochrome b562

  4. Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav Figshare

    ID: doi:10.6084/M9.FIGSHARE.4903439.V1

    Release Date: 04-24-2017

    Description: P2Y12-I in Austria

  5. Contemporary use of P2Y12 in Austria_P ONE_Tscharre_et_al.sav Figshare

    ID: doi:10.6084/M9.FIGSHARE.4903439

    Release Date: 04-24-2017

    Description: P2Y12-I in Austria

  6. Platelet microRNA expression profiles of acute coronary syndrome patients with high and low platelet reactivity ArrayExpress

    ID: E-GEOD-59488

    Description: ts using human miRNA microarray system. VerifyNow P2Y12 assay was applied to indentify HPR and LPR. Venous blood was drawn from the patients and was centrifuged to prepare platelets. Among the candidate differentially expressed miRNAs, miR-15b expression was further confirmed to be lower in platelets of 22 HPR patients than 17 LPR by quantitative reverse-transcription polymerase chain reaction (RT-qPCR). We enrolled a consecutive cohort of 290 ACS patients and assessed the platel...

  7. Expression data from untreated and ATP treated AML blasts ArrayExpress

    ID: E-GEOD-30903

    Description: xpress several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimulation (reflecting the variability intrinsic to the group of acute myeloid leukemias), all the tested samples appear to be responsive to purinergic signalling, as demonstrated by intracellular calcium mo...

  8. Loss of mouse P2Y6 nucleotide receptor is associated with physiological macrocardia and amplified pathological cardiac hypertrophy BioProject

    ID: PRJNA306654

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Transcription profiling of human CD34+ cells and treatment with UTP and CXCL12 ArrayExpress

    ID: E-GEOD-5168

    Description: -dependent chemotactic responses, suggesting that G-protein alpha-subunits (Gαi) may provide a converging signal for CXCR4- and P2Y-activated transduction pathways. In addition, gene expression profiling of UTP-treated CD34+ cells and in vitro inhibition assays demonstrated that Rho guanosine 5’-triphosphatases (GTPase) Rac2 and downstream effectors Rho GTPase–activated kinases 1 and 2 (ROCK1/2) are involved in UTP-promoted/CXCL12-dependent HSC migration. Our data suggest that UTP may physiologically modulate the migration of HSCs and their homing to the BM, in concert with CXCL12, via the activation of converging signaling pathways between CXCR4 and P2Y receptors, involving Gαi proteins and RhoGTPases. Experiment Overall Design: Highly purified CD34+ cells from 6 healthy donors were seeded at 1000000 cells/ml in serum free medium (EX vivo 15) w/o cytokines and treated with 10 mM UTP, 150ng/ml CXCL12, or ...

  10. Expression data for pharmacogenomics antiplatelet therapy ArrayExpress

    ID: E-GEOD-32226

    Description: aluate platelet reactivity by VerifyNow® ASA and P2Y12 assays and mRNA expression was measured by Affymetrix GeneChip Human Exon 1.0 ST array....

  11. Platelet microRNA expression profiles of acute coronary syndrome patients with high and low platelet reactivity BioProject

    ID: PRJNA255420

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ts using human miRNA microarray system. VerifyNow P2Y12 assay was applied to indentify HPR and LPR. Venous blood was drawn from the patients and was centrifuged to prepare platelets. Among the candidate differentially expressed miRNAs, miR-15b expression was further confirmed to be lower in platelets of 22 HPR patients than 17 LPR by quantitative reverse-transcription polymerase chain reaction (RT-qPCR). Overall design: We enrolled a consecutive cohort of 290 ACS patients and ass...
  12. Expression data from untreated and ATP treated AML blasts BioProject

    ID: PRJNA144221

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: xpress several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimulation (reflecting the variability intrinsic to the group of acute myeloid leukemias), all the tested samples appear to be responsive to purinergic signalling, as demonstrated by intracellular calcium mo...
  13. Expression data for pharmacogenomics antiplatelet therapy BioProject

    ID: PRJNA147205

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: aluate platelet reactivity by VerifyNow® ASA and P2Y12 assays and mRNA expression was measured by Affymetrix GeneChip Human Exon 1.0 ST array....
  14. CD34+ and Treatment with UTP and CXCL12 BioProject

    ID: PRJNA96575

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -dependent chemotactic responses, suggesting that G-protein alpha-subunits (Gαi) may provide a converging signal for CXCR4- and P2Y-activated transduction pathways. In addition, gene expression profiling of UTP-treated CD34+ cells and in vitro inhibition assays demonstrated that Rho guanosine 5’-triphosphatases (GTPase) Rac2 and downstream effectors Rho GTPase–activated kinases 1 and 2 (ROCK1/2) are involved in UTP-promoted/CXCL12-dependent HSC migration. Our data suggest that UTP may physiologically modulate the migration of HSCs and their homing to the BM, in concert with CXCL12, via the activation of converging signaling pathways between CXCR4 and P2Y receptors, involving Gαi proteins and RhoGTPases. Keywords: treatment comparison Overall design: Highly purified CD34+ cells from 6 healthy donors were seeded at 1000000 cells/ml in serum free medium (EX vivo 15) w/o cytokines and treated with 10 mM UTP, 1...
  15. Juvenile obesity in Ossabaw swine produces artery-specific transcriptional changes ArrayExpress

    ID: E-GEOD-41636

    Description: L14, APOE, PLA2G7, LGALS3, SPP1, ITGB2, CYBB, and P2RY12. Furthermore, pathway analysis revealed the induction of pro-inflammatory and pro-oxidant pathways with obesity primarily in the LAD. Gene expression in the LAD perivascular fat was minimally altered with juvenile obesity. Together, we provide new evidence that obesity produces artery-specific changes in pre-translational regulation with a clear up-regulation of pro-atherogenic genes in the LAD. Our data may offer potential viable drug targets and mechanistic insights regarding the molecular precursors involved in the origins of over-nutrition and obesity-associated vascular disease. In particular, our results suggest that the oxLDL-LOX-1-NFκB signaling axis may be involved in the early initiation of a juvenile obesity-induced pro-atherogenic coronary artery phenotype. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n=5) and lean (n=6) juvenile Ossabaw pigs (age= 22 weeks). All three tissue types were taken ...

  16. P2Y12_MOUSE UniProt:Swiss-Prot

    ID: Q9CPV9

    Description: P2Y purinoceptor 12 Extracellular Helical; Name=1 Cytoplasmic Helical; Name=2 Extracellular Helical; Name=3 Cyto...

  17. Morphological and molecular characterization of human dermal lymphatic collectors BioProject

    ID: PRJNA344487

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eceptors 1, and 5; tachykinin receptors 1, and 2; purinergic receptors P2RX1, and 6, P2RY12, 13, and 14; 5-hydroxytryptamine receptors HTR2B, and 3C; and adrenoceptors α2A,B,C. Our studies represent the first comprehensive characterization of human epifascial lymphatic collectors, as a prerequisite for diagnosis and therapy. Overall design: The transcriptome of 6 different normal human lymphatic collectors (Lyko1, Lyko 4-12, Lyko 5, Lyko12, Lyko13, Lyko26) from the dermis of the thigh of women between 44 and 61 years of age was compared to cultures of human dermal lymphatic endothelial cells (LEC1, LEC2, HD-LEC9A) and a mixture of 3 different human dermal blood endothelial cells (HD-BEC-CA) to identify potential drug targets in the media of the collectors....
  18. Juvenile obesity in Ossabaw swine produces artery-specific transcriptional changes BioProject

    ID: PRJNA177786

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: L14, APOE, PLA2G7, LGALS3, SPP1, ITGB2, CYBB, and P2RY12. Furthermore, pathway analysis revealed the induction of pro-inflammatory and pro-oxidant pathways with obesity primarily in the LAD. Gene expression in the LAD perivascular fat was minimally altered with juvenile obesity. Together, we provide new evidence that obesity produces artery-specific changes in pre-translational regulation with a clear up-regulation of pro-atherogenic genes in the LAD. Our data may offer potential viable drug targets and mechanistic insights regarding the molecular precursors involved in the origins of over-nutrition and obesity-associated vascular disease. In particular, our results suggest that the oxLDL-LOX-1-NFκB signaling axis may be involved in the early initiation of a juvenile obesity-induced pro-atherogenic coronary artery phenotype. Overall design: We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n=5) and lean (n=6) juvenile Ossabaw pigs (age= 22 weeks). All three tissue t...
  19. Platelet microRNA expression profiles of acute coronary syndrome patients with high and low platelet reactivity OmicsDI

    ID: E-GEOD-59488

    Date Released: 07-18-2014

    Description: ts using human miRNA microarray system. VerifyNow P2Y12 assay was applied to indentify HPR and LPR. Venous blood was drawn from the patients and was centrifuged to prepare platelets. Among the candidate differentially expressed miRNAs, miR-15b expression was further confirmed to be lower in platelets of 22 HPR patients than 17 LPR by quantitative reverse-transcription polymerase chain reaction (RT-qPCR). We enrolled a consecutive cohort of 290 ACS patients and assessed the platel...

  20. Juvenile obesity in Ossabaw swine produces artery-specific transcriptional changes OmicsDI

    ID: E-GEOD-41636

    Date Released: 06-02-2014

    Description: L14, APOE, PLA2G7, LGALS3, SPP1, ITGB2, CYBB, and P2RY12. Furthermore, pathway analysis revealed the induction of pro-inflammatory and pro-oxidant pathways with obesity primarily in the LAD. Gene expression in the LAD perivascular fat was minimally altered with juvenile obesity. Together, we provide new evidence that obesity produces artery-specific changes in pre-translational regulation with a clear up-regulation of pro-atherogenic genes in the LAD. Our data may offer potential viable drug targets and mechanistic insights regarding the molecular precursors involved in the origins of over-nutrition and obesity-associated vascular disease. In particular, our results suggest that the oxLDL-LOX-1-NFκB signaling axis may be involved in the early initiation of a juvenile obesity-induced pro-atherogenic coronary artery phenotype. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n=5) and lean (n=6) juvenile Ossabaw pigs (age= 22 weeks). All three tissue types were taken ...


Displaying 20 of 21 results for "P2RY12"