OPTN | bioCADDIE Data Discovery Index
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Displaying 20 of 28 results for "OPTN"
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  1. MYO6_CHICK UniProt:Swiss-Prot

    ID: Q9I8D1

    Description: almodulin Three-helix bundle SAH Interaction with OPTN Glu-rich Phosphothreonine Phosphothreonine Phosphothreonine In isoform 2. No effect on binding to OPTN; when associated with A-1091 Abolishes binding to OPTN; when associated with E-1091 No effect on bindin...

  2. Crystal structure of OPTN NTD and TBK1 CTD complex PDB

    ID: PDB:5EOF

    Description: Optineurin, Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  3. Crystal structure of OPTN E50K mutant and TBK1 complex PDB

    ID: PDB:5EOA

    Description: Optineurin, Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  4. LC3B OPTN-LIR Ptot complex structure PDB

    ID: PDB:2LUE

    Description: Microtubule-associated proteins 1A/1B light chain 3B, Optineurin

  5. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1394959

    Release Date: 03-11-2016

    Description:

  6. NMR Solution Structure of Optineurin Zinc-finger Domain PDB

    ID: PDB:2LO4

    Description: Optineurin

    gene.name: OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
  7. Crystal structure of Optineurin UBAN in complex with linear ubiquitin PDB

    ID: PDB:5B83

    Description: tetra ubiquitin, Optineurin

    gene.name: OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
  8. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1394959.V1

    Release Date: 03-11-2016

    Description:

  9. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1394959.V3

    Release Date: 03-11-2016

    Description:

  10. OPTN_XENLA UniProt:Swiss-Prot

    ID: Q5M7B7

    Description: Optineurin CCHC NOA-type

    gene.name: optn
  11. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1394959.V2

    Release Date: 03-11-2016

    Description:

  12. MYO6_MOUSE UniProt:Swiss-Prot

    ID: Q64331

    Description: almodulin Three-helix bundle SAH Interaction with OPTN Phosphoserine Phosphothreonine Phosphoserine Phosphoserine Phosphoserine In Snell's waltzer....

  13. Genome-wide analysis of monocyte derived macrophages from Crohn's Disease patients and controls ArrayExpress

    ID: E-GEOD-60083

    Description: atients. The most common of these was optineurin (OPTN) which was under-expressed in approximately 10% of the CD patients. Reduced OPTN expression coincided with lower intracellular protein levels and diminished cytokine secretion after bacterial stimulation both in the patients and with siRNA knockdown in THP-1 cells. Identifying and studying subgroups of patients with shared defective gene expression could aid our understanding of the mechanisms underlying highly heterogeneous diseases such as CD. Total RNA obtained from monocyte derived macrophages from Crohn's disease patients (n=58) or healthy volenteers (n=42) were cultured for six days before being stimulated with heat killed E. coli for four hours or left unstimulated....

  14. OPTN_MACMU UniProt:Swiss-Prot

    ID: Q861Q8

    Description: Optineurin CCHC NOA-type Interaction with Rab8 Interaction with HD Interaction with MYO6 LIR UBAN Phosphoserine; by TBK1 Phosphoserine Phosphoserine P...

    gene.name: OPTN
  15. OPTN_PONAB UniProt:Swiss-Prot

    ID: Q5R923

    Description: Optineurin CCHC NOA-type Interaction with Rab8 Interaction with HD Interaction with MYO6 LIR UBAN Phosphoserine; by TBK1 Phosphoserine Phosphoserine

    gene.name: OPTN
  16. OPTN_CHICK UniProt:Swiss-Prot

    ID: Q90Z16

    Description: Optineurin CCHC NOA-type LIR UBAN

    gene.name: OPTN
  17. OPTN_PIG UniProt:Swiss-Prot

    ID: Q7YS99

    Description: Optineurin CCHC NOA-type Interaction with Rab8 Interaction with HD Interaction with MYO6 LIR UBAN Phosphoserine; by TBK1 Phosphoserine Phosphoserine P...

    gene.name: OPTN
  18. Genome-wide analysis of monocyte derived macrophages from Crohn's Disease patients and controls OmicsDI

    ID: E-GEOD-60083

    Date Released: 08-08-2014

    Description: atients. The most common of these was optineurin (OPTN) which was under-expressed in approximately 10% of the CD patients. Reduced OPTN expression coincided with lower intracellular protein levels and diminished cytokine secretion after bacterial stimulation both in the patients and with siRNA knockdown in THP-1 cells. Identifying and studying subgroups of patients with shared defective gene expression could aid our understanding of the mechanisms underlying highly heterogeneous diseases such as CD. Total RNA obtained from monocyte derived macrophages from Crohn's disease patients (n=58) or healthy volenteers (n=42) were cultured for six days before being stimulated with heat killed E. coli for four hours or left unstimulated....

  19. Identification of genes that are linked with optineurin expression BioProject

    ID: PRJNA99173

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Genome-wide analysis of monocyte derived macrophages from Crohn's Disease patients and controls BioProject

    ID: PRJNA257514

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: atients. The most common of these was optineurin (OPTN) which was under-expressed in approximately 10% of the CD patients. Reduced OPTN expression coincided with lower intracellular protein levels and diminished cytokine secretion after bacterial stimulation both in the patients and with siRNA knockdown in THP-1 cells. Identifying and studying subgroups of patients with shared defective gene expression could aid our understanding of the mechanisms underlying highly heterogeneous diseases such as CD. Overall design: Total RNA obtained from monocyte derived macrophages from Crohn's disease patients (n=58) or healthy volenteers (n=42) were cultured for six days before being stimulated with heat killed E. coli for four hours or left unstimulated....

Displaying 20 of 28 results for "OPTN"