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Displaying 20 of 49 results for "OLR1"
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  1. DHA supplementation suppresses LDLR and OLR1 gene expression in blood cells from hypertriglyceridemic men BioProject

    ID: PRJNA124247

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Lectin-type oxidized LDL receptor 1 defines population of polymorphonuclear myeloid-derived suppressor cells in cancer patients ArrayExpress

    ID: E-GEOD-79404

    Description: ched gene regulators and oxidized LDL receptor 1 (OLR1) was one of the most overexpressed genes in PMN-MDSC. Lectin-type oxidized LDL receptor 1 (LOX-1) encoded by OLR1 was expressed in only 0.7% of neutrophils in peripheral blood of healthy donors, whereas 5-15% of neutrophils in cancer patients and 15-50% of neutrophils in tumor tissues were LOX-1+. In contrast to their LOX-1- counterparts, LOX-1+ neutrophils had gene signature, biochemical and functional characteristics of PMN-MDSC. Induction of ER stress in neutrophils from healthy donors up-regulated LOX-1 expression and converted these cells to suppressive PMN-MDSC. Thus, PMN-MDSC have distinct gene signature and LOX-1 can define this population of cells, which may provide new in...

  3. Lectin-type oxidized LDL receptor 1 defines population of polymorphonuclear myeloid-derived suppressor cells in cancer patients BioProject

    ID: PRJNA315707

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ched gene regulators and oxidized LDL receptor 1 (OLR1) was one of the most overexpressed genes in PMN-MDSC. Lectin-type oxidized LDL receptor 1 (LOX-1) encoded by OLR1 was expressed in only 0.7% of neutrophils in peripheral blood of healthy donors, whereas 5-15% of neutrophils in cancer patients and 15-50% of neutrophils in tumor tissues were LOX-1+. In contrast to their LOX-1- counterparts, LOX-1+ neutrophils had gene signature, biochemical and functional characteristics of PMN-MDSC. Induction of ER stress in neutrophils from healthy donors up-regulated LOX-1 expression and converted these cells to suppressive PMN-MDSC. Thus, PMN-MDSC have distinct gene signature and LOX-1 can define this population of cells, which may provide new in...
  4. Crystal structure of the W150A mutant LOX-1 CTLD showing impaired OxLDL binding PDB

    ID: PDB:3VLG

    Description: Oxidized low-density lipoprotein receptor 1

    gene.name: OLR1
  5. Comparison of transcriptomes of LOX-1 KO and WT mice and effects of angiotensin 2 ArrayExpress

    ID: E-MTAB-473

    Description: LOX KO and WT genotype comparison

  6. Transcription profiling by array of human peripheral blood mononuclear cells from patients with hypertriglyceridemia after treatment with docosahexaen... ArrayExpress

    ID: E-GEOD-20114

    Description: on of LDL receptor (LDLR), oxidized LDL receptor (OLR1), and cathepsin L1 (CTSL) was significantly suppressed by DHA supplementation; however, LPS stimulated the expression of LDLR and CTSL but not that of OLR1. LPS up-regulated and DHA suppressed the expression of prostaglandin E synthase (PTGES), PPAR delta, and various chemokines. Enrichment with Gene Ontology categories demonstrated that the genes related to transcription factor activity, immune responses, host defense responses, inflammatory responses, and apoptosis were inversely regulated by LPS and DHA. These results provide supporting evidence for the anti-inflammatory effects of DHA supplementation, and reveal previously unrecognized genes that are regulated by DHA, and are associated with risk factors of cardiovascular diseases. Double-blind, placebo-controlled parallel study with DHA supplementation to hypertriglyceridemic men. Gene expression detected in LPS-stimulated (LPS) and unstimulated (vehicle) white blood cells. 3-4 replicates per group....

  7. Transcription profiling by array of human peripheral blood mononuclear cells from patients with hypertriglyceridemia after treatment with docosahexaen... OmicsDI

    ID: E-GEOD-20114

    Date Released: 09-02-2015

    Description: on of LDL receptor (LDLR), oxidized LDL receptor (OLR1), and cathepsin L1 (CTSL) was significantly suppressed by DHA supplementation; however, LPS stimulated the expression of LDLR and CTSL but not that of OLR1. LPS up-regulated and DHA suppressed the expression of prostaglandin E synthase (PTGES), PPAR delta, and various chemokines. Enrichment with Gene Ontology categories demonstrated that the genes related to transcription factor activity, immune responses, host defense responses, inflammatory responses, and apoptosis were inversely regulated by LPS and DHA. These results provide supporting evidence for the anti-inflammatory effects of DHA supplementation, and reveal previously unrecognized genes that are regulated by DHA, and are associated with risk factors of cardiovascular diseases. Double-blind, placebo-controlled parallel study with DHA supplementation to hypertriglyceridemic men. Gene expression detected in LPS-stimulated (LPS) and unstimulated (vehicle) white blood cells. 3-4 replicates per group....

  8. Resolution of Type 2 Diabetes Following Bariatric Surgery is Associated with Changes in Whole Blood Gene Expression ArrayExpress

    ID: E-GEOD-19790

    Description: 1, CAMP, DEFA1, LCN2, TP53, ZNF684, GPR50, PDSS1, OLR1, CNTNAP5, DHCR24, HHAT and SARDH, which have been previously implicated in lipid metabolism, obesity and/or type 2 diabetes. The changes in expression of seven transcripts, WDR35, FLF45244, DHCR24, TIGD7, TOPBP1, TSHZ1, and FAM8A1 were strongly correlated with the changes in body weight, fasting plasma glucose and HbA1c content. These preliminary data suggest that whole blood expression levels of specific transcripts may identify biomarkers associated with susceptibility for type 2 diabetes and/or therapeutic response. Trasncriptome profiling was performed on eleven obese subjects with type 2 diabetes, (5 females and 6 males) to compare expression changes before and 6 to 12 months after the subjects underwent bariatric surgery....

  9. Lectin-type oxidized LDL receptor 1 defines population of polymorphonuclear myeloid-derived suppressor cells in cancer patients OmicsDI

    ID: E-GEOD-79404

    Date Released: 07-31-2016

    Description: ched gene regulators and oxidized LDL receptor 1 (OLR1) was one of the most overexpressed genes in PMN-MDSC. Lectin-type oxidized LDL receptor 1 (LOX-1) encoded by OLR1 was expressed in only 0.7% of neutrophils in peripheral blood of healthy donors, whereas 5-15% of neutrophils in cancer patients and 15-50% of neutrophils in tumor tissues were LOX-1+. In contrast to their LOX-1- counterparts, LOX-1+ neutrophils had gene signature, biochemical and functional characteristics of PMN-MDSC. Induction of ER stress in neutrophils from healthy donors up-regulated LOX-1 expression and converted these cells to suppressive PMN-MDSC. Thus, PMN-MDSC have distinct gene signature and LOX-1 can define this population of cells, which may provide new in...

  10. Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) at low pH PDB

    ID: PDB:1YXJ

    Description: oxidised low density lipoprotein (lectin-like) receptor 1

  11. Transcription profiling of human monocyte-derived dendritic cells to compare the phenotypes of interferon-alpha and interleukin-4 conditioned dendriti... ArrayExpress

    ID: E-MEXP-2000

    Description: The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major challenge in immu...

  12. Resolution of Type 2 Diabetes Following Bariatric Surgery is Associated with Changes in Whole Blood Gene Expression BioProject

    ID: PRJNA121811

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 1, CAMP, DEFA1, LCN2, TP53, ZNF684, GPR50, PDSS1, OLR1, CNTNAP5, DHCR24, HHAT and SARDH, which have been previously implicated in lipid metabolism, obesity and/or type 2 diabetes. The changes in expression of seven transcripts, WDR35, FLF45244, DHCR24, TIGD7, TOPBP1, TSHZ1, and FAM8A1 were strongly correlated with the changes in body weight, fasting plasma glucose and HbA1c content. These preliminary data suggest that whole blood expression levels of specific transcripts may identify biomarkers associated with susceptibility for type 2 diabetes and/or therapeutic response. Overall design: Trasncriptome profiling was performed on eleven obese subjects with type 2 diabetes, (5 females and 6 males) to compare expression changes before and 6 to 12 months after the subjects underwent bariatric surgery....
  13. Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex PDB

    ID: PDB:1YPQ

    Description: oxidised low density lipoprotein (lectin-like) receptor 1

  14. Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) disulfide-linked dimer PDB

    ID: PDB:1YXK

    Description: oxidised low density lipoprotein (lectin-like) receptor 1

  15. Human monocyte-derived dendritic cells treated with U0126 or SB203580 ArrayExpress

    ID: E-GEOD-39745

    Description: d migration (CCR7) and LDL binding (CD36, SCARB1, OLR1, CXCL16) by immature DC. Besides, ERK upregulated CCL2 expression while impaired the expression of DC maturation markers (RUNX3, ITGB7, IDO1). MEK-ERK-regulated genes exhibited an over-representation of cognate sequences for the Aryl Hydrocarbon Receptor (AhR) transcription factor, and we show that AhR mediates some of the ERK-dependent transcriptional effects in DC. Therefore, MEK-ERK signaling pathway regulates antigen capture, lymph node homing and the acquisition of maturation-associated genes, and its contribution to the maintenance of the immature state of MDDC and myeloid DC is partly dependent on the activity of AhR. Since pharmacological modulation of the MEK-ERK signaling...

  16. Human Oxidized Low Density Lipoprotein Receptor LOX-1 P3 1 21 Space Group PDB

    ID: PDB:1YPO

    Description: oxidised low density lipoprotein (lectin-like) receptor 1

  17. Human Oxidized Low Density Lipoprotein Receptor LOX-1 C2 Space Group PDB

    ID: PDB:1YPU

    Description: oxidised low density lipoprotein (lectin-like) receptor 1

  18. Molecular mechanism of statin-mediated LOX-1 inhibition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1407382.V8

    Release Date: 03-11-2016

    Description:

  19. Molecular mechanism of statin-mediated LOX-1 inhibition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1407382.V13

    Release Date: 03-11-2016

    Description:

  20. Molecular mechanism of statin-mediated LOX-1 inhibition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1407382.V16

    Release Date: 03-11-2016

    Description:


Displaying 20 of 49 results for "OLR1"