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Displaying 20 of 302 results for "NRIP1"
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  1. The role of RIP140 in retinoid mediated signaling BioProject

    ID: PRJNA100483

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. siRNA knock down of RIP140 in the presence of retinoic acid vs controls to investigate the role of RIP140 in retinoid mediated signaling ArrayExpress

    ID: E-GEOD-7500

    Description: Cell-and context-specific activities of nuclear receptors may in part be due to distinct coregulator complexes recruited to distinct subsets of target genes.

  3. Integrative genomics of gene regulation by estrogen receptors and and coregulators [ChIP-seq] ArrayExpress

    ID: E-GEOD-42348

    Description: at these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules. Cistrome and transcriptome analyses and use of clustering algorithms delineated 11 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and S...

  4. Co-activator function of RIP140 for NFκB/p65-dependent cytokine gene ArrayExpress

    ID: E-GEOD-10386

    Description: e describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a master transcriptional regulator of inflammation in multiple tissues. Genetic as well as acute deficiency of RIP140, which has bee...

  5. Integrative genomics of gene regulation by estrogen receptors and and coregulators [ChIP-seq] BioProject

    ID: PRJNA181136

    Keywords: Epigenomics

    Access Type: download

    dataset.description: at these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules. Cistrome and transcriptome analyses and use of clustering algorithms delineated 11 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and S...
  6. Transcription profiling of mouse adipocytes to determine the role of RIP140 in adipocyte differentiation ArrayExpress

    ID: E-MIMR-42

    Description: Title: Gene Expression analysis of the role of RIP140 in adipocyte differentiation Description: RIPKO cells are mouse embryo fibroblasts (MEF) that were derived from

  7. Co-activator function of RIP140 for NFκB/p65-dependent cytokine gene OmicsDI

    ID: E-GEOD-10386

    Date Released: 03-27-2012

    Description: e describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a master transcriptional regulator of inflammation in multiple tissues. Genetic as well as acute deficiency of RIP140, which has bee...

  8. RNAi profiling by array of human HEC-1B endometrial tumor cell lines with silencing of NRIP1 ArrayExpress

    ID: E-MTAB-820

    Description: Measuring the effect of silencing of NRIP1 in an endometrial tumour cell line on gene expression.

  9. Integrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression] ArrayExpress

    ID: E-GEOD-42347

    Description: at these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules. Cistrome and transcriptome analyses and use of clustering algorithms delineated 11 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and S...

  10. Co-activator function of RIP140 for NF?B/p65-dependent cytokine gene BioProject

    ID: PRJNA108129

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (mRNA) ArrayExpress

    ID: E-GEOD-24506

    Description: en cell motility (also a target of miR-125b); and NRIP1/RIP140, which modulates the transcriptional activity of the estrogen receptor. Knockdown of the putative oncogenic miRNAs miR-182 and miR-183, both highly over-expressed in DCIS, increased the expression of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. Two total samples were analyzed via Affymetrix U133A. Case numbers correspond to individual patients. Each sample is identified by case number, histologic lesion and corresponding microarray ID....

  12. Analysis of the receptor-interacting protein-140 (RIP140/Nrip1)-dependent transcriptome in the mouse adipogenic program NURSA

    Keywords: WAT adipocytes MEF-derived

    Description: ne was generated using lentiviral transduction of RIP140/Nrip1 KO MEFs with a RIP140/Nrip1 expression construct. RIPKO-L16 cells were isolated undifferentiated or after adi...

    ID: 10.1621/WugGwn4VIV

  13. Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 PDB

    ID: PDB:2GPP

    Description: Estrogen-related receptor gamma, Nuclear receptor-interacting protein

  14. Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 PDB

    ID: PDB:2GPO

    Description: Estrogen-related receptor gamma, Nuclear receptor-interacting protein

  15. Integrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression] BioProject

    ID: PRJNA181135

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: at these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules. Cistrome and transcriptome analyses and use of clustering algorithms delineated 11 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and S...
  16. Analysis of the receptor interacting protein-140 (RIP140/NRIP1)-dependent transcriptome in all-trans retinoic acid (ATRA)-treated NT2/D1 cells NURSA

    Keywords: pluripotent NT2-D1 cells

    Description: cells were transfected with control siRNA or anti-RIP140 siRNA and treated with or without 10 µM ATRA for 24 h....

    ID: 10.1621/2rZg95Zitd

  17. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (microRNA) ArrayExpress

    ID: E-GEOD-24508

    Description: en cell motility (also a target of miR-125b); and NRIP1/RIP140, which modulates the transcriptional activity of the estrogen receptor. Knockdown of the putative oncogenic miRNAs miR-182 and miR-183, both highly over-expressed in DCIS, increased the expression of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. The expression of 365 microRNAs were measured in 19 total samples via multiplex reverse transcription PCR using the TaqMan Human MicroRNA Low Density Array. Patients age ranged from 42-75. Equal amounts of total RNA from 9 reduction mammoplasty samples (age range 42-75) were combined into a pooled RM control (PRM), this sample was run in triplicate. Remaining 16 samples consist of matched samples of ductal carcinoma in situ and adjacent histologically normal breast epithelium, these are identified by case number and histologic lesion....

  18. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (mRNA) BioProject

    ID: PRJNA133519

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: en cell motility (also a target of miR-125b); and NRIP1/RIP140, which modulates the transcriptional activity of the estrogen receptor. Knockdown of the putative oncogenic miRNAs miR-182 and miR-183, both highly over-expressed in DCIS, increased the expression of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. Overall design: Two total samples were analyzed via Affymetrix U133A. Case numbers correspond to individual patients. Each sample is identified by case number, histologic lesion and corresponding microarray ID....
  19. Interphase condensins regulate ligand-depedent enhancer activation (ChIP-seq) BioProject

    ID: PRJNA263508

    Keywords: Epigenomics

    Access Type: download

    dataset.description: iol-induced preferential recruitment to oestrogen receptor α (ER-α)-bound active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-α distinct from classic cofactors. Condensins prove to positively regulate ligand-dependent gene and eRNA transcription by modulating a binding equilibrium of enhancer-associated coactivators/corepressors, including p300 and RIP140. This activity was achieved by the condensin-dependent recruitment of an E3 ubiquitin ligase, HECTD1, to active enhancers, where it ...
  20. A mouse Embryonic Stem Cell Bank for inducible overexpression of human chromosome 21 genes BioProject

    ID: PRJNA122055

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: oarray analysis: Bach1, Erg, Ets2, Gabpa, ZFP295, Nrip1, Olig1, Olig2, Pknox1, 1810007M14Rik, Runx1, Aire, Sim2, Dscr1, DYRK1A, SNF1LK, Ripk4 , Hunk, Pdxk, Pfkl. Overall design: Each triplicate clone was transcriptionally profiled by microarray analysis using Affymetrix Mouse 430_2 arrays before and after induction (Affymetrix 430A_2 in case of Runx1), yielding six arrays for each overexpression experiment....

Displaying 20 of 302 results for "NRIP1"