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Displaying 20 of 31 results for "NRG4"
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  1. Wild type and Neuregulin 4 (Nrg4) knockout mouse livers BioProject

    ID: PRJNA233620

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Wild type and Neuregulin 4 (Nrg4) knockout mouse livers OmicsDI

    ID: E-GEOD-53877

    Date Released: 11-28-2014

    Description: Nrg4 is a brown fat-enriched adipokine that binds to the liver and preserves metabolic homeostasis during chronic energy excess. Ad...

  3. Wild type and Neuregulin 4 (Nrg4) knockout mouse livers ArrayExpress

    ID: E-GEOD-53877

    Description: Nrg4 is a brown fat-enriched adipokine that binds to the liver and preserves metabolic homeostasis during chronic energy excess. Ad...

  4. NRG4_MOUSE UniProt:Swiss-Prot

    ID: Q9WTX4

    Description: Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 Extracellular Helical; N...

  5. Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta PDB

    ID: PDB:3U7U

    Description: Receptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1), Neuregulin 1

  6. NRG2_HUMAN UniProt:Swiss-Prot

    ID: O14511

    Description: Pro-neuregulin-2, membrane-bound isoform Neuregulin-2 Extracellular Helical; Note=Internal signal sequence Cytoplasm...

  7. Data from: Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity Dryad

    DateIssued: 03-28-2012

    Description: them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. ...

  8. The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer OmicsDI

    ID: E-GEOD-40949

    Date Released: 05-03-2014

    Description: ncomitant mRNA expression profiling revealed that neuregulin-1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system...

  9. The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer ArrayExpress

    ID: E-GEOD-40949

    Description: ncomitant mRNA expression profiling revealed that neuregulin-1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system...

  10. Tree_used_in_trait_analyses Dryad

    DateIssued: 01-03-2012

    Description: Phylogenetic tree used in trait analysis, branch length were derived from the complete tree

    identifiers.ID: doi:10.5061/dryad.3h3f3380/4
  11. The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer BioProject

    ID: PRJNA175424

    Keywords: Epigenomics

    Access Type: download

  12. Gene expression profile in DRG neurons over-expressing NRG1 type III intracellular domain BioProject

    ID: PRJNA262101

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: NA from DRG neurons over-expressing EGFP. We used 4 biological replicates and two technical replicates for each condition....
  13. Gene expression profile in DRG neurons over-expressing NRG1 type III intracellular domain ArrayExpress

    ID: E-GEOD-61784

    Description: NA from DRG neurons over-expressing EGFP. We used 4 biological replicates and two technical replicates for each condition....

  14. SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4 PDB

    ID: PDB:1HRF

    Description: HEREGULIN-ALPHA (EPIDERMAL GROWTH FACTOR-LIKE DOMAIN) (NMR, 10 STRUCTURES)

    primaryPublication.title: Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.
  15. SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4 PDB

    ID: PDB:1HRE

    Description: HEREGULIN-ALPHA (EPIDERMAL GROWTH FACTOR-LIKE DOMAIN) (NMR, MINIMIZED AVERAGE STRUCTURE)

    primaryPublication.title: Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.
  16. Crystal structure of the human retinal protein 4 (unc-119 homolog A). Northeast Structural Genomics Consortium target HR3066a PDB

    ID: PDB:3GQQ

    Description: Protein unc-119 homolog A

  17. Gene expression profiling on mouse models of cardiomyopathies BioProject

    ID: PRJNA118353

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ating evidence demonstrates the essential role of neuregulin signaling in the adult heart, and morerover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong evidence, the precise molecular interactions and the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this study, we examined potential molecular targets and mechanisms underlying the synergistic cardiotoxicity of anthracyclines in the ventricular muscle spec...
  18. Transcription profiling of human MCF7 breast cancer cells MCF-7 two hours post incubation with heregulin (HRG)) vs. controls to detect HRG regulated g... ArrayExpress

    ID: E-GEOD-8471

    Description: . However, with respect to enriched upstream TFs, 4 common TFs were identified in the 14 HRG-regulated (28.6%) and 13 E2-regulated (30.8%) gene groups. These results indicated that while E2 and HRG may induce common TFs, the regulatory mechanisms that govern HRG- and E2-induced gene expression differ. Experiment Overall Design: MCF-7 human breast cancer cells were incubated 2hour after administration of 10nM of the growth hormones (heregulin (HRG)). Control was set as growth hormone non-treated cells....

  19. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex ArrayExpress

    ID: E-GEOD-11546

    Description: The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing ri...

  20. Expression profiles of MicroRNA and SiRNA of Arabidopsis thaliana Col-0 and transgenic plants ArrayExpress

    ID: E-GEOD-11535

    Description: type and NRG1 plants grown at 22ºC and 30ºC for 4 weeks with TRIzol reagent according to the manufacturer’s protocol (Invitrogen). Small RNAs (<300nt) were isolated using a YM-100 Microcon centrifugal filter (Millipore), and 3’-extended with a poly(A) tail for later fluorescent dye staining. Two different tags were used for the two RNA samples labeled with Cy3 or Cy5 fluorescent dyes in dual-sample experiments. Also dye-swap experiments were carried out to control for labeling bias. Hybridization was performed overnight on a µParafloTM microfluidic chip. Each miRNA and siRNA had 6 and 3 repeat prints, respectively. Six replicate arrays were performed with six independent pairs of RNA samples. After hybridization, array images were obtained using an Axon GenePix 4000B laser scanner and digitized using the Array-Pro ...


Displaying 20 of 31 results for "NRG4"