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Displaying 19 of 19 results for "NPTX2"
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  1. PRJNA355191 BioProject

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: We report that hippocampal neuronal pentraxin 2 (Nptx2) plays an important role in mediating anxiety. To better understa...
  2. NPTXR_RAT UniProt:Swiss-Prot

    ID: O35764

    Description: Neuronal pentraxin receptor Cytoplasmic Helical; Signal-anchor for type II membrane protein E...

  3. NPTXR_MOUSE UniProt:Swiss-Prot

    ID: Q99J85

    Description: Neuronal pentraxin receptor Cytoplasmic Helical; Signal-anchor for type II membrane protein E...

  4. NPTX2_MOUSE UniProt:Swiss-Prot

    ID: O70340

    Description: Neuronal pentraxin-2 Pentaxin Calcium 1 Calcium 1 Calcium 2 Calcium 1; via carbonyl oxygen Calcium 1 Calcium 2 C...

  5. NPTX2_CAVPO UniProt:Swiss-Prot

    ID: P47970

    Description: Neuronal pentraxin-2 Pentaxin Calcium 1 Calcium 1 Calcium 2 Calcium 1; via carbonyl oxygen Calcium 1 Calcium 2 C...

  6. Transcription profiling of mouse brain Homer1a-expressing cells after sleep deprivation ArrayExpress

    ID: E-GEOD-9443

    Description: ee other activity-induced genes (Ptgs2, Jph3, and Nptx2) were identified by this technique to be over-expressed after sleep loss. All four genes play a role in recovery from glutamate-induced neuronal hyperactivity. The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness. Experiment Overall Design: Experiments were performed on male mice, 12 weeks of age +/- 1 week. Animals were housed in polycarbonate cages (31x18x18cm) in an experimental room with an ambient temperature varying from 23° to 25°C under a 12:12 hrs light/dark cycle. Food and water were available ad libitum. At light onset mice were either sleep deprived by gentle handling (n=10) or left undisturbed (n=10) for...

  7. Transcriptome Sequencing (RNAseq) enables utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Explorati... ArrayExpress

    ID: E-GEOD-76207

    Description: in both datasets were carbonic anhydrase 9 (CA9), neuronal pentraxin-2 (NPTX2) and uromodulin (UMOD) that were confirmed by immunohistochemistry. IPA revealed the presence of gene signatures of cancer and nephrotoxicity, renal damage and immune response. To simulate the feasibility of clinical biomarker studies with FFPE samples, a classifier model was developed for the FFPE dataset: expression data for CA9 alone had an accuracy, specificity and sensitivity of 94%, respectively, and achieved similar performance in the RNAlater dataset. Transforming growth factor-ß1 (TGFB1)-regulated genes, epithelial to mesenchymal transition (EMT) and NOTCH signaling cascade may support novel therapeutic strategies. In conclusion, in this proof of concept study, RNAseq data obtained from FFPE kidney biopsies are comparable to data obtained from fresh stored material, thereby expanding the utility of archival tissue specimens. *** Access to raw data can be requested from submitters ***...

  8. Identification of genes upregulated by MeTA-array in human pancreatic cancers ArrayExpress

    ID: E-GEOD-26215

    Description: enes by RT-PCR with Southern hybridization, NEFH, NPTX2, SFRP1, TIMP3, and UCHL1; these genes are known to be methylated in at least any one of these cancer cell lines. Upregulation by “MeTA” was confirmed in all of these genes. Then we searched for upregulated-genes, by two-folds or more, in all the three cancer cell lines after MeTA; nineteen such upregulated genes were identified. Among these, sixteen genes except NEFH, HOXA9, and CLDN5 have not been reported previously using the conventional DNA methylation inhibitors. Methylation status of two genes, SLC32A1 and CSMD2, were further analyzed by methylation-specific PCR and found that SLC32A1 and CSMD2 were methylated in 100% (21/21) and 83% (15/18) pancreatic cancer cell lines analyzed, respectively. Our results suggest that “MeTA” is a highly efficient method to isolate methylation-mediated transcriptionally silenced genes in human pancreatic cancer and that this method can be applied to other types of human cancer. Three representative pancreatic cancer cell lines, AsPC-1, MIA PaCa-2, and PANC-1, with a normal pancreatic ductal epithelial cell line HPDE (as the control) were transfected with pcDNA6/myc-His vector or pcDNA6-3xFLAG-NFkB (AD)-MBD and were harvested 48 h after transfection....

  9. Complex structure of PCAF bromodomain with small chemical ligand NP2 PDB

    ID: PDB:1WUM

    Description: Histone acetyltransferase PCAF (E.C.2.3.1.48)

  10. Crystal Structure of NP2-B17 TCR-H2Db-NP complex PDB

    ID: PDB:5SWS

    Description: H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, influenza NP366 epitope, NP1-B17 TCR alpha chain, NP1-B17 TCR beta chai...

  11. Identification of genes upregulated by MeTA-array in human pancreatic cancers BioProject

    ID: PRJNA134971

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: enes by RT-PCR with Southern hybridization, NEFH, NPTX2, SFRP1, TIMP3, and UCHL1; these genes are known to be methylated in at least any one of these cancer cell lines. Upregulation by “MeTA” was confirmed in all of these genes. Then we searched for upregulated-genes, by two-folds or more, in all the three cancer cell lines after MeTA; nineteen such upregulated genes were identified. Among these, sixteen genes except NEFH, HOXA9, and CLDN5 have not been reported previously using the conventional DNA methylation inhibitors. Methylation status of two genes, SLC32A1 and CSMD2, were further analyzed by methylation-specific PCR and found that SLC32A1 and CSMD2 were methylated in 100% (21/21) and 83% (15/18) pancreatic cancer cell lines analyzed, respectively. Our results suggest that “MeTA” is a highly efficient method to isolate methylation-mediated transcriptionally silenced genes in human pancreatic cancer and that this method can be applied to other types of human cancer. Overall design: Three representative pancreatic cancer cell lines, AsPC-1, MIA PaCa-2, and PANC-1, with a normal pancreatic ductal epithelial cell line HPDE (as the control) were transfected with pcDNA6/myc-His vector or pcDNA6-3xFLAG-NFkB (AD)-MBD and were harvested 48 h after transfection....
  12. Gene expression in brain Homer1a-expressing cells after sleep deprivation BioProject

    ID: PRJNA105159

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ee other activity-induced genes (Ptgs2, Jph3, and Nptx2) were identified by this technique to be over-expressed after sleep loss. All four genes play a role in recovery from glutamate-induced neuronal hyperactivity. The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness. Keywords: sleep deprivation, neuronal subpopulation transcriptome Overall design: Experiments were performed on male mice, 12 weeks of age +/- 1 week. Animals were housed in polycarbonate cages (31x18x18cm) in an experimental room with an ambient temperature varying from 23° to 25°C under a 12:12 hrs light/dark cycle. Food and water were available ad libitum. At light onset mice were eith...
  13. Gene expression in brain Homer1a-expressing cells after sleep deprivation GEMMA

    ID: 742

    Keywords: functional genomics

    Description: ee other activity-induced genes (Ptgs2, Jph3, and Nptx2) were identified by this technique to be over-expressed after sleep loss. All four genes play a role in recovery from glutamate-induced neuronal hyperactivity. The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness. Last Updated (by provider): Dec 07 2007 Contributers: Paul Franken Stéphanie Maret Mehdi Tafti Alexandra Paillusson Otto Hagenbuchle Laure Gurcel Sylvain Pradervand...

  14. RNA immunoprecipitation (RIP) of IGF2BP3 from pancreatic cancer cell extracts cultured on fibronectin BioProject

    ID: PRJNA206465

    Keywords: Other

    Access Type: download

  15. Transcriptome Sequencing (RNAseq) enables utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Explorati... OmicsDI

    ID: E-GEOD-76207

    Date Released: 01-16-2016

    Description: in both datasets were carbonic anhydrase 9 (CA9), neuronal pentraxin-2 (NPTX2) and uromodulin (UMOD) that were confirmed by immunohistochemistry. IPA revealed the presence of gene signatures of cancer and nephrotoxicity, renal damage and immune response. To simulate the feasibility of clinical biomarker studies with FFPE samples, a classifier model was developed for the FFPE dataset: expression data for CA9 alone had an accuracy, specificity and sensitivity of 94%, respectively, and achieved similar performance in the RNAlater dataset. Transforming growth factor-ß1 (TGFB1)-regulated genes, epithelial to mesenchymal transition (EMT) and NOTCH signaling cascade may support novel therapeutic strategies. In conclusion, in this proof of concept study, RNAseq data obtained from FFPE kidney biopsies are comparable to data obtained from fresh stored material, thereby expanding the utility of archival tissue specimens. *** Access to raw data can be requested from submitters ***...

  16. Video 8. CLSM on macrophage and neutrophil behavior at the exponential phase of Mm infection. Dryad

    DateIssued: 08-02-2016

    Description: Double transgenic Tg(mpeg1:EGFP) and Tg(lyz:DsRed2) larvae infected with Mm were imaged alive every ~60 sec at 3 dpi for 2.5 hours by CLSM (Nikon A1) ...

  17. NPTXR_HUMAN UniProt:Swiss-Prot

    ID: O95502

    Description: Neuronal pentraxin receptor Cytoplasmic Helical; Signal-anchor for type II membrane protein E...

  18. Identification of genes upregulated by MeTA-array in human pancreatic cancers OmicsDI

    ID: E-GEOD-26215

    Date Released: 06-02-2014

    Description: enes by RT-PCR with Southern hybridization, NEFH, NPTX2, SFRP1, TIMP3, and UCHL1; these genes are known to be methylated in at least any one of these cancer cell lines. Upregulation by “MeTA” was confirmed in all of these genes. Then we searched for upregulated-genes, by two-folds or more, in all the three cancer cell lines after MeTA; nineteen such upregulated genes were identified. Among these, sixteen genes except NEFH, HOXA9, and CLDN5 have not been reported previously using the conventional DNA methylation inhibitors. Methylation status of two genes, SLC32A1 and CSMD2, were further analyzed by methylation-specific PCR and found that SLC32A1 and CSMD2 were methylated in 100% (21/21) and 83% (15/18) pancreatic cancer cell lines analyzed, respectively. Our results suggest that “MeTA” is a highly efficient method to isolate methylation-mediated transcriptionally silenced genes in human pancreatic cancer and that this method can be applied to other types of human cancer. Three representative pancreatic cancer cell lines, AsPC-1, MIA PaCa-2, and PANC-1, with a normal pancreatic ductal epithelial cell line HPDE (as the control) were transfected with pcDNA6/myc-His vector or pcDNA6-3xFLAG-NFkB (AD)-MBD and were harvested 48 h after transfection....

  19. Transcription profiling of mouse brain Homer1a-expressing cells after sleep deprivation OmicsDI

    ID: E-GEOD-9443

    Date Released: 03-27-2012

    Description: ee other activity-induced genes (Ptgs2, Jph3, and Nptx2) were identified by this technique to be over-expressed after sleep loss. All four genes play a role in recovery from glutamate-induced neuronal hyperactivity. The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness. Experiment Overall Design: Experiments were performed on male mice, 12 weeks of age +/- 1 week. Animals were housed in polycarbonate cages (31x18x18cm) in an experimental room with an ambient temperature varying from 23° to 25°C under a 12:12 hrs light/dark cycle. Food and water were available ad libitum. At light onset mice were either sleep deprived by gentle handling (n=10) or left undisturbed (n=10) for...


Displaying 19 of 19 results for "NPTX2"