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Displaying 20 of 565 results for "NPAS4"
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  1. Npas4-regulated genes in mouse hippocampal neurons BioProject

    ID: PRJNA109195

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons (array) BioProject

    ID: PRJNA240171

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons (array) ArrayExpress

    ID: E-GEOD-55588

    Description: ivity-induced early-response transcription factor Npas4, we repeated the same experiment in the MGE- and CTX-cultures lacking Npas4 (Npas4-KO). Littermate mouse E14 MGE- or CTX-derived neurons (WT or KO for Npas4) were cultured for 9 days, quieted overnight with TTX and AP-5 and then membrane-depolarized for 0, 1 or 6 hours by raising the extracellular KCl-concentration to 55mM. RNA was then extracted and analyzed using Affymetrix GeneChip Mouse Expression Set 430...

  4. Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons (array) OmicsDI

    ID: E-GEOD-55588

    Date Released: 06-06-2015

    Description: ivity-induced early-response transcription factor Npas4, we repeated the same experiment in the MGE- and CTX-cultures lacking Npas4 (Npas4-KO). Littermate mouse E14 MGE- or CTX-derived neurons (WT or KO for Npas4) were cultured for 9 days, quieted overnight with TTX and AP-5 and then membrane-depolarized for 0, 1 or 6 hours by raising the extracellular KCl-concentration to 55mM. RNA was then extracted and analyzed using Affymetrix GeneChip Mouse Expression Set 430...

  5. RNAi profiling of mouse hippocampal neurons infected with lentivirus expressing Npas4-RNAi or control-RNAiNpas4-regulated genes ArrayExpress

    ID: E-GEOD-11258

    Description: ted genes that are misregulated in the absence of Npas4. Experiment Overall Design: We infected mouse hippocampal neurons with lentivirus expressing Npas4-RNAi or control-RNAi @ 3 DIV and depolarized the neurons @ 8 DIV with 50 mM ...

  6. NPAS4_RAT UniProt:Swiss-Prot

    ID: Q8CJH6

    Description: Neuronal PAS domain-containing protein 4 bHLH

  7. Hippocampal gene expression in aged and young HSD1 knockout mice OmicsDI

    ID: E-GEOD-68515

    Date Released: 11-28-2015

    Description: genes) with no genotype differences. However, the neuronal-specific transcription factor, Npas4 and immediate early gene, Arc were reduced (relative to young) in the hippocampus of memory-impaired but not unimpaired aged wild-type or aged 11β-HSD1-deficient mice. Quantitative RT-PCR and in situ hybridization confirmed reduced Npas4 and Arc mRNA expression in memory-impaired aged wild-type mice. These findings suggest that 11β-HSD1 may contribute to the decline in Npas4 and Arc mRNA levels associated with memory impairment during ageing, and that decreased activity of synaptic plasticity pathways involving Npas4 and Arc may, in part, underlie the memory deficits seen in cognitively-impaired aged wild-type mice. 20 samples, ...

  8. Hippocampal gene expression in aged and young HSD1 knockout mice ArrayExpress

    ID: E-GEOD-68515

    Description: genes) with no genotype differences. However, the neuronal-specific transcription factor, Npas4 and immediate early gene, Arc were reduced (relative to young) in the hippocampus of memory-impaired but not unimpaired aged wild-type or aged 11β-HSD1-deficient mice. Quantitative RT-PCR and in situ hybridization confirmed reduced Npas4 and Arc mRNA expression in memory-impaired aged wild-type mice. These findings suggest that 11β-HSD1 may contribute to the decline in Npas4 and Arc mRNA levels associated with memory impairment during ageing, and that decreased activity of synaptic plasticity pathways involving Npas4 and Arc may, in part, underlie the memory deficits seen in cognitively-impaired aged wild-type mice. 20 samples, ...

  9. Hippocampal gene expression in aged and young HSD1 knockout mice BioProject

    ID: PRJNA282964

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: genes) with no genotype differences. However, the neuronal-specific transcription factor, Npas4 and immediate early gene, Arc were reduced (relative to young) in the hippocampus of memory-impaired but not unimpaired aged wild-type or aged 11β-HSD1-deficient mice. Quantitative RT-PCR and in situ hybridization confirmed reduced Npas4 and Arc mRNA expression in memory-impaired aged wild-type mice. These findings suggest that 11β-HSD1 may contribute to the decline in Npas4 and Arc mRNA levels associated with memory impairment during ageing, and that decreased activity of synaptic plasticity pathways involving Npas4 and Arc may, in part, underlie the memory deficits seen in cognitively-impaired aged wild-type mice. Overall desi...
  10. Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons ArrayExpress

    ID: E-GEOD-55591

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  11. Npas4-regulated genes in mouse hippocampal neurons GEMMA

    ID: 1197

    Keywords: functional genomics

    Description: ted genes that are misregulated in the absence of Npas4. Last Updated (by provider): Mar 15 2009 Contributers: Michael E Greenberg Yingxi Lin...

  12. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes ArrayExpress

    ID: E-GEOD-61887

    Description: Neuronal activity causes the rapid expression of immediate early genes that are crucial for experience driven changes to synapses, ...

  13. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes BioProject

    ID: PRJNA262622

    Keywords: Other

    Access Type: download

  14. Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons OmicsDI

    ID: E-GEOD-55591

    Date Released: 06-03-2014

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  15. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes OmicsDI

    ID: E-GEOD-61887

    Date Released: 08-19-2015

    Description: Neuronal activity causes the rapid expression of immediate early genes that are crucial for experience driven changes to synapses, ...

  16. Structure Prediction Of Neuronal Per- Arnt- Sim (b-hlh-pas) Protein- Npas4 Using Insightii And M... Figshare

    ID: doi:10.6084/M9.FIGSHARE.884483.V1

    Release Date: 01-18-2016

    Description:

  17. Structure Prediction Of Neuronal Per- Arnt- Sim (b-hlh-pas) Protein- Npas4 Using Insightii And M... Figshare

    ID: doi:10.6084/M9.FIGSHARE.884483

    Release Date: 07-04-2014

    Description:

  18. Methamphetamine administration causes differential alterations in gene expression and dynamic patterns of histone acetylation/hypoacetylation in the r... ArrayExpress

    ID: E-GEOD-31081

    Description: creases in the expression of many genes including Npas4 and cholecystokin (Cck). Pathway analyses showed that differentially affected genes participate in behavioral performance, cell-to-cell signaling and interactions, and regulation of gene expression. Other differentially affected genes are known to be involved in cellular compromise and death pathways. PCR analyses were used to confirm the changes in the expression of c-fos, fosB, c-jun, junB, Crf, NmU, Cck, and Npas4 transcripts. Western blot analyses also identified METH-mediated decreases in the acetylation of histone H3 at lysine 9 (H3K9) and lysine 18 (H3K18) as well as in histone 4 at lysine 16 (H4K16). In contrast, the METH injection caused time-dependent increases in the acetylation of H4K8 and H4K12. The changes in histone acetylation were also accompanied by decreased expression of HDAC1 but increased expression of ATF2 and of HDAC2. These results suggest that METH-induced alterations in global gene expression might be due, in part, to diverse effects of METH-induced histone acetylation secondary to changes in HAT and HDAC expression. At the indicated time after the METH or saline injections, rats (n = 5 per group) were euthanized and the NAc was dissected and immediately put on dry ice. The tissues were kept at -70 oC until RNA extraction. Total RNA ...

  19. Transcription profiling of mouse primary cultured neurons to identify activity related gene expression ArrayExpress

    ID: E-GEOD-11261

    Description: ulated genes in mouse cortical neurons; GSE11258: Npas4-regulated genes in mouse hippocampal neurons Experiment Overall Design: Refer to individual Series...

  20. mRNA sequencing of two brain regions (prefrontal cortex and hippocampus) and left myocardial tissue in mice with chronic heart failure vs. sham-operat... ArrayExpress

    ID: E-GEOD-55280

    Description: rature describes some of the genes (RORA, Gabrb2, Npas4, and Junb) being associated with depression-like behavior. Nr4a1 significantly regulated in both brain and heart tissue after induction of ischemic CHF could be a potential link and reveals the central role of inflammation in the interrelation of the brain and the failing heart. Heart failure vs. sham-operation were performed in C57BL/6 male mice. After development of chronic heart failure (CHF) 8 weeks after the operation RNA was extracted out of prefrontal cortex, hippocampus and left ventricular myocardium in both groups. RNA of 3 ischemic CHF mice versus 6 sham operated mice was pooled and further subjected to RNA sequencing. To fabricate singular pools each probe of the group equally contributed with the final amount of 2 µg RNA per pool with the result that we had 6 different pools to be further evaluated. The mRNA profile was generated by IGA Technology, Italy () by deep sequencing, using Illumina HiSeq 2000 platform (HiSeq). CLC-Bio Genomics Workbench software (CLC Bio, Denmark) was used to calculate gene expression lev...


Displaying 20 of 565 results for "NPAS4"