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Displaying 16 of 16 results for "NNMT"
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  1. Expression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes BioProject

    ID: PRJNA134985

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: GH-down-regulated genes, including IGF-1, SOCS2, NNMT, IGFLS, P4AH1, SLC16A1, and SRD5A1, and FADS1 and AKR1B10, respectively. Overall design: The chimeric mice were treated or untreated with h-GH at 2.5 mg/kg b.w. /day for 2 weeks before sacrifice. Hepatocytes or liver tissue were isolated from the mouse livers and their cDNAs were used for microarray analysis....
  2. Human Nicotinamide N-methyltransferase PDB

    ID: PDB:2IIP

    Description: Nicotinamide N-methyltransferase (E.C.2.1.1.1)

    gene.name: NNMT
  3. Expression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes ArrayExpress

    ID: E-GEOD-26224

    Description: GH-down-regulated genes, including IGF-1, SOCS2, NNMT, IGFLS, P4AH1, SLC16A1, and SRD5A1, and FADS1 and AKR1B10, respectively. The chimeric mice were treated or untreated with h-GH at 2.5 mg/kg b.w. /day for 2 weeks before sacrifice. Hepatocytes or liver tissue were isolated from the mouse livers and their cDNAs were used for microarray analysis....

  4. The metabolome regulates the epigenetic landscape during naìˆve to primed human embryonic stem cell transition BioProject

    ID: PRJNA259889

    Keywords: Other

    Access Type: download

    dataset.description: revealed consistent changes in the expression of NNMT (higher in naive state) and IDO1 (higher in primed state) and in the concentration of corresponding metabolic substrates and products. As a regulator of S-Adenosyl methionine (SAM) level, NNMT is proposed as a candidate regulator of epigenetic states. ChIP-seq analysis releaved that naive lines have lower H3K27me3 marks in developmental genes. Inhibition of STAT3, a known regulator of NNMT, reduces NNMT expression level and decreases overall H3K27me3 marks around transcriptional start sites. In particular, STAT3 inhibitor treatment increased H3K27me3 marks in 313 genes that al...
  5. Mouse Nicotinamide N-methyltransferase PDB

    ID: PDB:2I62

    Description: Nicotinamide N-methyltransferase (E.C.2.1.1.1)

    gene.name: Nnmt
  6. Methyltransferase PDB

    ID: PDB:3ROD

    Description: Nicotinamide N-methyltransferase (E.C.2.1.1.1)

    gene.name: NNMT
  7. NNMT_MOUSE UniProt:Swiss-Prot

    ID: O55239

    Description: Nicotinamide N-methyltransferase S-adenosyl-L-methionine binding S-adenosyl-L-methionine binding S-adenosyl-L-methionine binding S-adenosyl-L-methioni...

    gene.name: Nnmt
  8. NNMT_HUMAN UniProt:Swiss-Prot

    ID: P40261

    Description: Nicotinamide N-methyltransferase S-adenosyl-L-methionine binding S-adenosyl-L-methionine binding S-adenosyl-L-methionine S-adenosyl-L-methionine S-ade...

    gene.name: NNMT
  9. NNMT_PIG UniProt:Swiss-Prot

    ID: Q06AV1

    Description: Nicotinamide N-methyltransferase S-adenosyl-L-methionine binding S-adenosyl-L-methionine binding S-adenosyl-L-methionine S-adenosyl-L-methionine S-ade...

    gene.name: NNMT
  10. Expression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes OmicsDI

    ID: E-GEOD-26224

    Date Released: 06-02-2014

    Description: GH-down-regulated genes, including IGF-1, SOCS2, NNMT, IGFLS, P4AH1, SLC16A1, and SRD5A1, and FADS1 and AKR1B10, respectively. The chimeric mice were treated or untreated with h-GH at 2.5 mg/kg b.w. /day for 2 weeks before sacrifice. Hepatocytes or liver tissue were isolated from the mouse livers and their cDNAs were used for microarray analysis....

  11. Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways ArrayExpress

    ID: E-GEOD-11244

    Description: re Ddit4, a key regulator of the TOR pathway, and Nnmt, a regulator of lifespan linked to the Sirtuin pathway. Using Western analyses, we confirmed post-translational inhibition of the TOR pathway. Conclusions: Our data show that CR induces widespread gene expression changes and acts through highly evolutionarily conserved pathways, from microorganisms to mammals, and that its life-extension effects might arise partly from a shift toward a gene expression profile more typical of the longer-lived female sex. Keywords: Two-class gene expression comparison. Calorie restriction (CR) versus HIGH CALORIE feeding. Design of the experiment is a two-class paired design in which the two classes are HIGH CALORIE and CALORIE RESTRICTION (CR) dietary regimens fed to mice, resulting in 15 HIGH CALORIE microarrays and 8 CR microarrays; 23 total microarrays. Four HIGH CALORIE and 2 CR microarrays were produced using pools of 3 RNA samples for each microarray (6 pools of 3, plus 17 individual samples = 35 individual mouse liver samples, 23 microarrays). Total liver RNA was labeled directly. Reference RNA: Stratagene Universal Mouse Reference RNA....

  12. Reciprocal communication between endometrial stromal cells and macrophages ArrayExpress

    ID: E-GEOD-19834

    Description: pholamban, CYR61/CCN1, CTGF/CCN2, tenascin C, and NNMT, whereas integrin alpha 6 was down-regulated. In contrast, 15 named genes were differentially expressed in macrophages in response to factors secreted by cultured endometrial stromal cells. The data document reciprocal communication between macrophages and endometrial stromal cells and suggest that interaction with macrophages stimulates the expression of genes in endometrial stromal cells that contribute to migration, adhesion, invasion, neovascularization and mitosis of endometrial cells that may support the establishment of endometriosis. Experiment Design: Goal of the experiment: To examine reciprocal communication between a telomerase-immortalized human endometrial stromal cell line (THESC, ATCC #CRL-4003) and U-937 macrophages (ATCC #CRL-1593.2 treated with phorbol ester to stimulate differentiation), and also to assess t...

  13. Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways OmicsDI

    ID: E-GEOD-11244

    Date Released: 05-02-2014

    Description: re Ddit4, a key regulator of the TOR pathway, and Nnmt, a regulator of lifespan linked to the Sirtuin pathway. Using Western analyses, we confirmed post-translational inhibition of the TOR pathway. Conclusions: Our data show that CR induces widespread gene expression changes and acts through highly evolutionarily conserved pathways, from microorganisms to mammals, and that its life-extension effects might arise partly from a shift toward a gene expression profile more typical of the longer-lived female sex. Keywords: Two-class gene expression comparison. Calorie restriction (CR) versus HIGH CALORIE feeding. Design of the experiment is a two-class paired design in which the two classes are HIGH CALORIE and CALORIE RESTRICTION (CR) dietary regimens fed to mice, resulting in 15 HIGH CALORIE microarrays and 8 CR microarrays; 23 total microarrays. Four HIGH CALORIE and 2 CR microarrays were produced using pools of 3 RNA samples for each microarray (6 pools of 3, plus 17 individual samples = 35 individual mouse liver samples, 23 microarrays). Total liver RNA was labeled directly. Reference RNA: Stratagene Universal Mouse Reference RNA....

  14. Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways BioProject

    ID: PRJNA106749

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: re Ddit4, a key regulator of the TOR pathway, and Nnmt, a regulator of lifespan linked to the Sirtuin pathway. Using Western analyses, we confirmed post-translational inhibition of the TOR pathway. Conclusions: Our data show that CR induces widespread gene expression changes and acts through highly evolutionarily conserved pathways, from microorganisms to mammals, and that its life-extension effects might arise partly from a shift toward a gene expression profile more typical of the longer-lived female sex. Keywords: Two-class gene expression comparison. Calorie restriction (CR) versus HIGH CALORIE feeding. Overall design: Design of the experiment is a two-class paired design in which the two classes are HIGH CALORIE and CALORIE RESTRICTION (CR) dietary regimens fed to mice, resulting in 15 HIGH CALORIE microarrays and 8 CR microarrays; 23 total microarrays. Four HIGH CALORIE and 2 CR microarrays were produced using pools of 3 RNA samples for each microarray (6 pools of 3, plus 17 individual samples = 35 individual mouse liver samples, 23 microarrays). Total liver RNA was labeled directly. Reference RNA: Stratagene Universal Mouse Reference RNA....
  15. Reciprocal communication between endometrial stromal cells and macrophages BioProject

    ID: PRJNA122051

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: pholamban, CYR61/CCN1, CTGF/CCN2, tenascin C, and NNMT, whereas integrin alpha 6 was down-regulated. In contrast, 15 named genes were differentially expressed in macrophages in response to factors secreted by cultured endometrial stromal cells. The data document reciprocal communication between macrophages and endometrial stromal cells and suggest that interaction with macrophages stimulates the expression of genes in endometrial stromal cells that contribute to migration, adhesion, invasion, neovascularization and mitosis of endometrial cells that may support the establishment of endometriosis. Overall design: Experiment Design: Goal of the experiment: To examine reciprocal communication between a telomerase-immortalized human endometrial stromal cell line (THESC, ATCC #CRL-4003) and U-937 macrophages (ATCC #CRL-1593.2 treated with phorbol ester to stimulate differentiation), and als...
  16. Reciprocal communication between endometrial stromal cells and macrophages OmicsDI

    ID: E-GEOD-19834

    Date Released: 03-27-2012

    Description: pholamban, CYR61/CCN1, CTGF/CCN2, tenascin C, and NNMT, whereas integrin alpha 6 was down-regulated. In contrast, 15 named genes were differentially expressed in macrophages in response to factors secreted by cultured endometrial stromal cells. The data document reciprocal communication between macrophages and endometrial stromal cells and suggest that interaction with macrophages stimulates the expression of genes in endometrial stromal cells that contribute to migration, adhesion, invasion, neovascularization and mitosis of endometrial cells that may support the establishment of endometriosis. Experiment Design: Goal of the experiment: To examine reciprocal communication between a telomerase-immortalized human endometrial stromal cell line (THESC, ATCC #CRL-4003) and U-937 macrophages (ATCC #CRL-1593.2 treated with phorbol ester to stimulate differentiation), and also to assess t...


Displaying 16 of 16 results for "NNMT"