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Displaying 20 of 67 results for "MYH11"
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  1. EM structure of the heavy meromyosin subfragment of Chick smooth muscle Myosin with regulatory light chain in phosphorylated state PDB

    ID: PDB:3J04

    Description: Myosin-11, Myosin regulatory light chain 2, smooth

  2. Transcription profiling by array of Mus musculus expressing Cbfb-MYH11 OmicsDI

    ID: E-GEOD-19194

    Date Released: 09-10-2015

    Description: It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transfor...

  3. Cbfb/Runx1-repression independent blockage of differentiation and accumulation of Csf2rb expressing cells by Cbfb-MYH11 BioProject

    ID: PRJNA120677

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP PDB

    ID: PDB:3DTP

    Description: Myosin-11, Myosin-7, Myosin light polypeptide 6, Myosin...

  5. Transcription profiling by array of Mus musculus expressing Cbfb-MYH11 ArrayExpress

    ID: E-GEOD-19194

    Description: It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transfor...

  6. A compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes OmicsDI

    ID: E-GEOD-46044

    Date Released: 09-26-2013

    Description: Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, inte...

  7. MOLECULAR INSIGHTS INTO PEBP2/CBF-SMMHC ASSOCIATED ACUTE LEUKEMIA REVEALED FROM THE THREE-DIMENSIONAL STRUCTURE OF PEBP2/CBF BETA PDB

    ID: PDB:1CL3

    Description: POLYOMAVIRUS ENHANCER BINDING PROTEIN 2 (PEBP2/CBF)

  8. A compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes BioProject

    ID: PRJNA197000

    Keywords: Other

    Access Type: download

  9. Accelerated leukemogenesis by truncated CBFb-SMMHC defective in high-affinity binding with RUNX1 ArrayExpress

    ID: E-GEOD-21155

    Description: posed as a common pathway for CBF-leukemia. CBFb-SMMHC, a fusion protein in human acute myeloid leukemia (AML), dominantly inhibits RUNX1 largely through its RUNX1 high-affinity binding domain (HABD). We generated knoc...

  10. The C-terminus of CBFß-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis ArrayExpress

    ID: E-GEOD-42238

    Description: The C-terminus of CBFß-SMMHC, the fusion protein produced by a chromosome 16 inversion in acute myeloid leukemia subtype M4Eo, contains domains for self-m...

  11. A compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes ArrayExpress

    ID: E-GEOD-46044

    Description: Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, inte...

  12. Accelerated leukemogenesis by truncated CBFb-SMMHC defective in high-affinity binding with RUNX1 BioProject

    ID: PRJNA126601

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. The C-terminus of CBFß-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis. BioProject

    ID: PRJNA182139

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. d oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis... BioProject

    ID: PRJNA323580

    Keywords: Epigenomics

    Access Type: download

  15. Transcription profiling by array of human umbilical cord blood cells with Leukemia fusion-genes ArrayExpress

    ID: E-GEOD-7011

    Description: nding Factor leukemia fusion (AML1-ETO or CBFbeta-SMMHC) in human CD34+ cells results in self-renewal of primitive progenitor cells with multilineage potential and stem cell ability, but these cells do not induce leukemia in immunodeficient mice. This comparative microarray study was initiated to determine how faithful these cell cultures are to the transcripto...

  16. Transcription profiling by array of H. sapiens acute myeloid leukemia mononuclear cells to investigate associations with distinct clinical and genetic... OmicsDI

    ID: E-MTAB-1356

    Date Released: 10-23-2015

    Description: n acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11

  17. Transcription profiling by array of H. sapiens acute myeloid leukemia mononuclear cells to investigate associations with distinct clinical and genetic... ArrayExpress

    ID: E-MTAB-1356

    Description: n acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11

  18. MYH11_CHICK UniProt:Swiss-Prot

    ID: P10587

    Description: Removed Myosin-11 Myosin motor IQ ATP Actin-binding Actin-binding Rodlike tail (S2 and LMM domains) B...

  19. Whole Genome Sequencing of CBF-Leukemia dbGaP

    ID: phs000414.v1.p1

    Description: L M4Eo express the chimeric fusion gene CBFβ-SMMHC(MYH11) as a result of an inversion/translocation event of chromosome 16 [inv(16)/t(16;16)]. In an effort to define the total complement of genetic changes in CBF-leukemia, we performed paired-end whole genome sequencing (WGS) on diagnostic leukemia blasts and matched germ line samples from 17 pediatric CBF-leukemia patients using the Illumina platform. Somatic alterations, including single nucleotide variations (SNVs) and structural variations (SVs), including insertions, deletions, inversions, and inter- and intra-chromosomal rearrangements, were detected using complementary analysis pipelines (Bambino, CREST and CONSERTING). Recurrent screening of identified mutations will be performed in a coh...

  20. Gene expression profiling using exon arrays during interference with PPAR gamma signaling in thoracic aorta ArrayExpress

    ID: E-GEOD-37195

    Description: ting dominant negative PPAR gamma to the vascular smooth muscle cells in order to determine the action of PPAR gamma in the blood vessel independent of its systemic metabolic actions. In the data set provided herein, we examined the gene expression profile in thoracic aorta from SP467L mice and their control littermates using the Affymetrix mouse exon 1.0 ST array. We generated transgenic mice specifically targeting expression of mutant dominant negative human PPAR gamma (P467L) to vascular smooth muscle using a smooth muscle-specific promoter (smooth muscle myosin heavy chain or


Displaying 20 of 67 results for "MYH11"