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Displaying 20 of 170 results for "MXI1"
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  1. siRNA knock-down of MXI1 in human neuroblastoma cells ArrayExpress

    ID: E-MEXP-2033

    Description: ere transfected in triplicates with siRNA against MXI1 or an unspecific control siRNA and grown at hypoxia (1 % O 2) for 24 hours. RNA extracted from each siMXI1 sample was hybridized to the corresponding co...

  2. Confirmation of the gene expression pattern in Mxi1-deficient mouse BioProject

    ID: PRJNA107041

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Confirmation of the gene expression pattern in Mxi1-deficient mouse (time course) BioProject

    ID: PRJNA107255

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. siRNA knock-down of MXI1 in human neuroblastoma cells OmicsDI

    ID: E-MEXP-2033

    Date Released: 05-02-2014

    Description: ere transfected in triplicates with siRNA against MXI1 or an unspecific control siRNA and grown at hypoxia (1 % O 2) for 24 hours. RNA extracted from each siMXI1 sample was hybridized to the corresponding co...

  5. Confirmation of the gene expression pattern in Mxi1-deficient mouse (time course) OmicsDI

    ID: E-GEOD-10941

    Date Released: 10-18-2011

    Description: ormation analyzing gene pattern in time-dependent Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes network map conc...

  6. Confirmation of the gene expression pattern in Mxi1-deficient mouse OmicsDI

    ID: E-GEOD-11053

    Date Released: 03-27-2012

    Description: ted with cyst formation analyzing gene pattern in Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes n...

  7. Confirmation of the gene expression pattern in Mxi1-deficient mouse ArrayExpress

    ID: E-GEOD-11053

    Description: ted with cyst formation analyzing gene pattern in Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes n...

  8. Stability selection for regression-based models of transcription factor-DNA binding specificity ArrayExpress

    ID: E-GEOD-47026

    Description: d using high resolution in vitro data from custom protein binding microarray (PBM) experiments. Our PBMs are specifically designed to cover a large number of putative DNA binding sites for the TFs of interest (yeast TFs Cbf1 and Tye7, and human TFs c-Myc, Max, and Mad2) in their native genomic context. These high-throughput, quantitative data are well suited for training complex models that take into account not only independent contributions from individual bases, but also contributions from di- and trinucleotides at various positions within or near the binding sites. To ensure that our models remain interpretable, we use feature selection to identify a small number of sequence features that accurately predict TF-DNA binding specificity. To ...

  9. Confirmation of the gene expression pattern in Mxi1-deficient mouse (time course) ArrayExpress

    ID: E-GEOD-10941

    Description: ormation analyzing gene pattern in time-dependent Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes network map conc...

  10. Tamoxifen induces expression of immune-response related genes in cultured NHMEC ArrayExpress

    ID: E-GEOD-13476

    Description: l interferon-induced genes (IFITM1, IFIT1, IFNA1, MXI and GIP3), and a potassium ion channel (KCNJ1). No significant expression changes were found for genes related to estrogen or xenobiotic metabolism. RT-PCR revealed TAM-induced up-regulation of the five genes of interest, and interferon รก (IFNA1), in all three NHMEC strains, with the exception of GIP3 and MX1, which were unchanged in strain 40. The magnitude of TAM-induced up-regulation ranked: strain 16 > strain 05> strain 40. The consistent induction of interferon-related genes in all three NHMEC strains suggests that, in addition to hormonal effects, TAM exposure may enhance immune response, through interferon induction, in normal breast tissue. RNA was extracted from three cell strains (NHMEC 98016, 98040 and 99005) and exposed on three separate occasions to 10 uM TAM. Comparisons were made using 16 arrays with 8 dye swaps for cell strain NHMEC 99005, 9 arrays with 4 dye swaps for NHMEC 98016, and 12 arrays with 6 dye swaps for NHMEC 98040....

  11. Stability selection for regression-based models of transcription factor-DNA binding specificity BioProject

    ID: PRJNA203302

    Keywords: Epigenomics

    Access Type: download

    dataset.description: d using high resolution in vitro data from custom protein binding microarray (PBM) experiments. Our PBMs are specifically designed to cover a large number of putative DNA binding sites for the TFs of interest (yeast TFs Cbf1 and Tye7, and human TFs c-Myc, Max, and Mad2) in their native genomic context. These high-throughput, quantitative data are well suited for training complex models that take into account not only independent contributions from individual bases, but also contributions from di- and trinucleotides at various positions within or near the binding sites. To ensure that our models remain interpretable, we use feature selection to identify a small number of sequence features that accurately predict TF-DNA binding specificity. To ...
  12. Disruption of FAT10-MAD2 binding inhibits tumor progression BioProject

    ID: PRJNA235857

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. MXI1_RAT UniProt:Swiss-Prot

    ID: O09015

    Description: Max-interacting protein 1 bHLH

  14. MXI1_DANRE UniProt:Swiss-Prot

    ID: P50541

    Description: Max-interacting protein 1 bHLH

  15. MXI1_MOUSE UniProt:Swiss-Prot

    ID: P50540

    Description: Max-interacting protein 1 bHLH In isoform Short. (in Ref. 3)

  16. Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex PDB

    ID: PDB:2QYF

    Description: Mitotic spindle assembly checkpoint protein MAD2A, MAD2L1-binding protein

  17. Parallel quantitative CRISPR interference in yeast identifies chemical-genetic interactions and new rules for guide RNA design ArrayExpress

    ID: E-GEOD-71490

    Description: yeast. Key features include ORFs expressing dCas9-Mxi1 and the tetracycline repressor (TetR), as well as a tetracycline inducible gRNA locus containing the RPR1 promoter with a TetO site, a NotI site for cloning new gRNA specificity sequences, and the constant part of the gRNA. When yeast containing this plasmid are grown in the absence of anhydrotetracycline (ATc) TetR binds the gRNA promoter and prevents PolIII from binding and transcribing the gRNA. This in turn prevents dCas9-Mxi1 from binding the target site. In the presence of ATc, TetR dissociates and gRNA is expressed, allowing dCas9-Mxi1 to bind its target locus, and repress gene expression. gRNA libraries were cloned into this construct and transformed into yeast to create pools. Experiments were conducted in which yeast pools were grown in inducing (+ATc) and non-inducing conditions (-ATc) in the presence of different drugs. After multiple generations of growth in these conditions, yeast plasmids were minipreped and the gRNA locus was PCRed and sequenced via MiSeq. Counts of each gRNA were compared in different conditions....

  18. Stability selection for regression-based models of transcription factor-DNA binding specificity OmicsDI

    ID: E-GEOD-47026

    Date Released: 06-03-2014

    Description: d using high resolution in vitro data from custom protein binding microarray (PBM) experiments. Our PBMs are specifically designed to cover a large number of putative DNA binding sites for the TFs of interest (yeast TFs Cbf1 and Tye7, and human TFs c-Myc, Max, and Mad2) in their native genomic context. These high-throughput, quantitative data are well suited for training complex models that take into account not only independent contributions from individual bases, but also contributions from di- and trinucleotides at various positions within or near the binding sites. To ensure that our models remain interpretable, we use feature selection to identify a small number of sequence features that accurately predict TF-DNA binding specificity. To ...

  19. SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2 PDB

    ID: PDB:1DUJ

    Description: SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2

  20. Parallel quantitative CRISPR interference in yeast identifies chemical-genetic interactions and new rules for guide RNA design BioProject

    ID: PRJNA291393

    Keywords: Other

    Access Type: download

    dataset.description: yeast. Key features include ORFs expressing dCas9-Mxi1 and the tetracycline repressor (TetR), as well as a tetracycline inducible gRNA locus containing the RPR1 promoter with a TetO site, a NotI site for cloning new gRNA specificity sequences, and the constant part of the gRNA. When yeast containing this plasmid are grown in the absence of anhydrotetracycline (ATc) TetR binds the gRNA promoter and prevents PolIII from binding and transcribing the gRNA. This in turn prevents dCas9-Mxi1 from binding the target site. In the presence of ATc, TetR dissociates and gRNA is expressed, allowing dCas9-Mxi1 to bind its target locus, and repress gene expression. gRNA libraries were cloned into this construct and transformed into yeast to create pools. Experiments were conducted in which yeast pools were grown in inducing (+ATc) and non-inducing conditions (-ATc) in the presence of different drugs. After multiple generations of growth in these conditions, yeast plasmids were minipreped and the gRNA locus was PCRed and sequenced via MiSeq. Counts of each gRNA were compared in different conditions....

Displaying 20 of 170 results for "MXI1"