MT1E | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 48 results for "MT1E"
i
  1. MT1E_PIG UniProt:Swiss-Prot

    ID: P79431

    Description: Metallothionein-1E Beta Alpha Divalent metal cation; cluster B Divalent metal cation; cluster B Divalent metal c...

  2. t methylenetetrahydromethanopterin dehydrogenase (MTD) from Methanopyrus kandleri... PDB

    ID: PDB:1U6K

    Description: F420-dependent methylenetetrahydromethanopterin dehydrogenase (E.C.1.5.99.9)

  3. miRNA expression profiles of erythroid cells following hydroxyurea treatment for sickle cell anemia ArrayExpress

    ID: E-GEOD-32035

    Description: nd patients receiving the maximum tolerated dose (MTD) of hydroxurea. CD71+ cells were isolated from whole blood of control individuals (n=2), pediatric patients without hydroxyurea treatment (n=3) and pediatric patients at hydroxyurea MTD (n=3). All 8 samples were analyzed for miRNA expression....

  4. Gene expression profile of biochemically recurrent prostate cancer BioProject

    ID: PRJNA351781

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e expression levels identified down-regulation of MT1E and GPR52 expression and up-regulation of EZH2 as the specific biomarkers of PCa progression, but only MT1E expression retained the independent prognostic value in a multivariate model. Aberrant methylation of the two fragments of MT1E promoter was frequent (71% and 60%) in PCa tissues as compared to NPT (p < 0.001) and was significantly associated with decreased expression in one of the PCa cohorts (p < 0.050). In conclusion, the data of our study suggest epigenetic inactivation of MT1E expression as the specific feature of PCa showing the tendency to progress. Overall design: Gene expression profile was analyzed in 8 PCa cases with BCR and compared to 8 BCR-free cases. No biological replicates were performed....
  5. miRNA expression profiles of erythroid cells following hydroxyurea treatment for sickle cell anemia BioProject

    ID: PRJNA147495

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd patients receiving the maximum tolerated dose (MTD) of hydroxurea. Overall design: CD71+ cells were isolated from whole blood of control individuals (n=2), pediatric patients without hydroxyurea treatment (n=3) and pediatric patients at hydroxyurea MTD (n=3). All 8 samples were analyzed for miRNA expression....
  6. Preclinical analysis of acquired resistance after prolonged efficacious metronomic oral topotecan chemotherapy plus pazopanib therapy in advanced ovar... ArrayExpress

    ID: E-GEOD-54621

    Description: p adjunct to conventional maximum tolerated dose (MTD) chemotherapy now in advanced phase III clinical trial assessment is metronomic chemotherapy?the close regular administration of low doses of drug with n...

  7. Preclinical analysis of acquired resistance after prolonged efficacious metronomic oral topotecan chemotherapy plus pazopanib therapy in advanced ovar... BioProject

    ID: PRJNA237207

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: p adjunct to conventional maximum tolerated dose (MTD) chemotherapy now in advanced phase III clinical trial assessment is metronomic chemotherapy?the close regular administration of low doses of drug with n...
  8. Transcription profiling of sheep prion accumulating ovine microglia ArrayExpress

    ID: E-GEOD-12688

    Description: whereas the response of three other transcripts (MT1E, NR4A1, PKP2) conflicted with previous reports. Overall, the results demonstrated a limited transcriptional response to PrPSc accumulation, when compared to microglia and macrophage cultures infected with other agents such as viruses and bacteria. This is the first microarray-based analysis of prion accumulation in primary cells derived from a natural TSE-host. Experiment Overall Design: Primary sheep microglial cells were either inoculated with PrPSc (Inoc) or sham-inoculated (Mock) Experiment Overall Design: Three biological replicates per treatment. Experiment Overall Design: Three technical replicates per biological replicate. Experiment Overall Design: biological replicate: Inoc12A, Inoc12B.2, Inoc12C Experiment Overall Design: biological replicate: Mock12A, Mock12B.2, Mock12C Experiment Overall Design: technical replicate - extract: Inoc12A.1, Inoc12A.2, Inoc12A.3 Experiment Overall Design: technical replicate - extract: Inoc12B.2.1, Inoc12B.2.2, Inoc12B.2.3 Experiment Overall Design: technical replicate - extract: Inoc12C.1, Inoc12C.2, Inoc12C.3 Experiment Overall Design: technical replicate - extract: Mock12A.1, Mock12A.2, Mock12A.3 Experiment Overall Design: technical replicate - extract: Mock12B.2.1, Mock12B.2.2, Mock12B.2.3 Experiment Overall Design: ...

  9. Gene expression profiles of ovarian tumor biopsies from Phase I dasatinib trial ArrayExpress

    ID: E-GEOD-37180

    Description: tive was to determine the maximum tolerated dose (MTD). Secondary objectives included toxicity, response rate (RR), pharmacokinetics and pharmacodynamics. Based on the 3+3 design, cohorts of 3-6 pts received paclitaxel 175 mg/m2 and carboplatin AUC 6 every three weeks with escalating doses of dasatinib (100, 120, 150 mg daily), followed by an 8 patient expansion cohort. Results: Twenty patients were enrolled between 06/07 and 12/09. The median age was 61 yrs (42-82) with a median of 2 prior regimens (0-6), and 71% had platinum-sensitive disease. There were ...

  10. t methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: A methanogenic enzyme with an unusual quarternary structure... PDB

    ID: PDB:1QV9

    Description: F420-dependent methylenetetrahydromethanopterin dehydrogenase (E.C.1.5.99.9)

  11. Major Tropism Determinant P1 (Mtd-P1) Variant Complexed with Bordetella brochiseptica Virulence Factor Pertactin extracellular domain (Prn-E). PDB

    ID: PDB:2IOU

    Description: Major Tropism Determinant P1/Pertactin Extracellular Domain

  12. NCIC CTG MA.22 phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer on 2-weekly or 3-weekly schedules ArrayExpress

    ID: E-GEOD-66999

    Description: uvant trial determined maximally-tolerated doses (MTD), dose-limiting toxicities (DLT), response-to-therapy, and explored the role of new response biomarkers. The combination regimens were delivered with...

  13. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylas... BioProject

    ID: PRJNA290402

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t eight genes (F2RL2, TFAP2B, EDNRA, FOXD3, SIX3, MT1E, ETS1, LHX2) are sufficient to separate HDACi from mercurials. Our data demonstrate, how human stem cells and transcriptome analysis can be combined for mechanistic grouping and prediction of toxicants. Extension of this concept to mechanisms beyond HDACi would allow prediction of human developmental toxicity hazard of unknown compounds with the UKN1 test system. Overall design: We applied a test system (next referred as the UKN1 test system) of developmental toxicity, related to the generation of neuroectoderm from human embryonic stem cells (hESCs), and exposed cells for six days to the histone deacetylase inhibitors (HDACi) valproic acid, trichostatin-A, vorinostat, belinostat, panobinostat and entinostat, as well as to the mercurial compounds methylmercury, thimerosal, mercury(II)chloride, mercury(II)bromide, 4-chloromercuribenzoic acid and phenylmercuric acid. After 6 days, total RNA has been isolated and gene expression studies were performed applying the human Genome U133 plus 2.0 arrays. Untreated and vehicle controls (Ethanol and DMSO) have been also investigated. At least four independent experiments have been performed....
  14. Microarrays analysis of anti-Enterovirus 71 activity of Heparin BioProject

    ID: PRJNA149797

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: case in that Hep likely suppresses regulation of Metallothionein 1E. Furthermore, it should not be ignored that the Hep-caused affects seen in this microarray analysis may partially be attributed to a significant inhibitory effect of Hep on EV71 entry into the cells. In conclusion, we propose that our microarray findings may suggest new directions for further studies on molecular targets of anti-EV71 activity of Hep. EV71 is a neurovirological virus that can cause severe and fatal CNS complications in infected patients. There is no approved drug for prophylaxis of EV71-casued disease and discovering a molecular drug target(s) for EV71 infection would be beneficial. The microarray analysis reported here was a large-scale microarray pilot study and thus further confirmatory experiments such as real time RT PCR and Western blotting would be warranted in order to confirm the mode of action of Hep implied here. Overall design: SK-N-SH cells were infected with a clinical EV71 isolate followed by treatment with 125 µg/mL of Hep. At 72 hours post infection, antiviral activity and cytotoxicity of Hep at 125 µg/mL in 12-well plates were carried out at the same time as RNA extraction. This way, we could ensure that we would assess transcript profiles of the host cells under the same condition and time as assessment of antiviral activity and cytotoxicity for the same replicates. Changes in expression profiles of the host cells were comparatively assessed under four conditions: cell control (neither infection nor treatment, designated CC), treated only with Hep (compound control, designated Cyto), EV71-infected cells treated with Hep (treatment, designated H), and infected with EV71 without treatment with Hep (v...
  15. Transcription profiling by array of Drosophila Mustard and Kenny mutants relative to control w1118 flies after access to food contaminated with Vibrio... ArrayExpress

    ID: E-GEOD-35439

    Description: We used microarrays to determine whether Key and Mtd have overlapping regulons. Key1 and Mtd mutant and CTL flies were given access to Vibrio cholerae in LB. After 24 hours, whole flies were homogenized and RNA was isolated....

  16. Expression profiling of prion accumulating ovine microglia BioProject

    ID: PRJNA112693

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: whereas the response of three other transcripts (MT1E, NR4A1, PKP2) conflicted with previous reports. Overall, the results demonstrated a limited transcriptional response to PrPSc accumulation, when compared to microglia and macrophage cultures infected with other agents such as viruses and bacteria. This is the first microarray-based analysis of prion accumulation in primary cells derived from a natural TSE-host. Keywords: disease state analysis Overall design: Primary sheep microglial cells were either inoculated with PrPSc (Inoc) or sham-inoculated (Mock) Three biological replicates per treatment. Three technical replicates per biological replicate. biological replicate: Inoc12A, Inoc12B.2, Inoc12C biological replicate: Mock12A, Mock12B.2, Mock12C technical replicate - extract: Inoc12A.1, Inoc12A.2, Inoc12A.3 technical replicate - extract: Inoc12B.2.1, Inoc12B.2.2, Inoc12B.2.3 technical replicate - extract: Inoc12C.1, Inoc12C.2, Inoc12C.3 technical replicate - extract: Mock12A.1, Mock12A.2, Mock12A.3 technical replicate - extract: Mock12B.2.1, Mock12B.2.2, Mock12B.2.3 technical replicate - extract: Mock12C.1, Mock12C.2, Mock12C.3...
  17. Differences in gene expression of Mustard and Kenny mutants relative to control w1118 flies 24 hours after access to food contaminated with Vibrio cho... BioProject

    ID: PRJNA152777

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We used microarrays to determine whether Key and Mtd have overlapping regulons. Overall design: Key1 and Mtd mutant and CTL flies were given access to Vibrio cholerae in LB. After 24 hours, whole flies were homogenized and RNA was iso...
  18. Preclinical analysis of acquired resistance after prolonged efficacious metronomic oral topotecan chemotherapy plus pazopanib therapy in advanced ovar... OmicsDI

    ID: E-GEOD-54621

    Date Released: 06-03-2014

    Description: p adjunct to conventional maximum tolerated dose (MTD) chemotherapy now in advanced phase III clinical trial assessment is metronomic chemotherapy?the close regular administration of low doses of drug with n...

  19. Transcription profiling of sheep prion accumulating ovine microglia OmicsDI

    ID: E-GEOD-12688

    Date Released: 06-10-2011

    Description: whereas the response of three other transcripts (MT1E, NR4A1, PKP2) conflicted with previous reports. Overall, the results demonstrated a limited transcriptional response to PrPSc accumulation, when compared to microglia and macrophage cultures infected with other agents such as viruses and bacteria. This is the first microarray-based analysis of prion accumulation in primary cells derived from a natural TSE-host. Experiment Overall Design: Primary sheep microglial cells were either inoculated with PrPSc (Inoc) or sham-inoculated (Mock) Experiment Overall Design: Three biological replicates per treatment. Experiment Overall Design: Three technical replicates per biological replicate. Experiment Overall Design: biological replicate: Inoc12A, Inoc12B.2, Inoc12C Experiment Overall Design: biological replicate: Mock12A, Mock12B.2, Mock12C Experiment Overall Design: technical replicate - extract: Inoc12A.1, Inoc12A.2, Inoc12A.3 Experiment Overall Design: technical replicate - extract: Inoc12B.2.1, Inoc12B.2.2, Inoc12B.2.3 Experiment Overall Design: technical replicate - extract: Inoc12C.1, Inoc12C.2, Inoc12C.3 Experiment Overall Design: technical replicate - extract: Mock12A.1, Mock12A.2, Mock12A.3 Experiment Overall Design: technical replicate - extract: Mock12B.2.1, Mock12B.2.2, Mock12B.2.3 Experiment Overall Design: ...

  20. Transcription profiling by array of Drosophila Mustard and Kenny mutants relative to control w1118 flies after access to food contaminated with Vibrio... OmicsDI

    ID: E-GEOD-35439

    Date Released: 04-30-2015

    Description: We used microarrays to determine whether Key and Mtd have overlapping regulons. Key1 and Mtd mutant and CTL flies were given access to Vibrio cholerae in LB. After 24 hours, whole flies were homogenized and RNA was isolated....


Displaying 20 of 48 results for "MT1E"