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Displaying 20 of 25 results for "MOGAT1"
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  1. Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice ArrayExpress

    ID: E-GEOD-60349

    Description: etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepa...

  2. Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice BioProject

    ID: PRJNA258077

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Liver gene expression signatures for type 2 diabetic mice and normal mice BioProject

    ID: PRJNA153213

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ys, we were able to show that the expression of a monoacylglycerol O-acyltransferase 1 (MOGAT1), an enzyme involved in triglyceride synthesis and storage, is elevated in the livers of obese diabetic mice. The in vivo silencing of hepatic Mogat1 via a non-viral siRNA delivery system resulted in a dramatic improvement in systemic glucose and lipid homeostasis. These interdisciplinary approaches have the potential to accelerate not only for identification of target gene, but also drug discovery and development. Overall design: Gene expression ...
  4. Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice OmicsDI

    ID: E-GEOD-60349

    Date Released: 11-08-2014

    Description: etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepa...

  5. MOGT1_BOVIN UniProt:Swiss-Prot

    ID: Q70VZ7

    Description: 2-acylglycerol O-acyltransferase 1 Helical Helical N-linked (GlcNAc...) N-linked (GlcNAc...)

  6. Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages ArrayExpress

    ID: E-GEOD-42190

    Description: ole for increases in long chain acyl CoA synthase 1 (ACSL1) and diacylglycerol acyltransferase-2 (DGAT2) during the sustained response to TLR2/4 activation; decreases in adipose triglyceride lipase (ATGL, Pnpla2) and monoacylglycerol lipase (MgII) may also contribute. Stimulated murine macrophages that retained TAG carried out phagocytosis more effectively and were protected from saturated fatty acid-induced cell death (lipotoxicity). TLR agonist-induced TAG retention in macrophages is thus an active, sustained process that may have important adaptive functions. It may also contribute to the persistence of lipid-laden macrophages in infected tissues, host susceptibility to some microbial pathogens, and the pathogenesis of atherosclerosis. RNA from macrophage loaded with Fatty Acids, stimulated with bacterial lipopolysaccharides (LPS), or both compared to untreated controls (FA, LPS, FA+LPS, untreated). Replicates from 4 independent experiments....

  7. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers ArrayExpress

    ID: E-GEOD-73103

    Description: licated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1,SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not be blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated to human diseases and traits. Bisulphite converted DNA from 355 individuals aged 14-34 were hybridised to the Illumina Infinium 450k Human Methylation Beadchip....

  8. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance ArrayExpress

    ID: E-GEOD-21903

    Description: de synthesis and storage, including Cidea, Cidec, Mogat1, and CD36, was greatly decreased in the liver of TAK1-/- mice. Moreover, TAK1-/- mice exhibit reduced infiltration of inflammatory cells and expression of inflammatory genes in adipose tissue and were resistant to the development of glucose intolerance and insulin resistance. TAK1-/- mice consume more oxygen and produce more carbon dioxide than WT mice suggesting a higher rate of energy expenditure. Together, these results indicate that TAK1 plays a critical role in the regulation of energy and lipid homeostasis and potentiates the development of metabolic syndrome. Our study suggests that TAK1 might provide a novel therapeutic target in the management of metabolic syndrome. ...

  9. Nuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance ArrayExpress

    ID: E-GEOD-23736

    Description: ynthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels in liver of RORasg/sg mice. In addition to reduced lipid accumulation, inflammation was greatly diminished in white adipose tissue (WAT) of RORasg/sg mice fed with a HFD. The infiltration of macrophages and the expression of many immune-response and pro-inflammatory genes, including those encoding various chemo/cytokines, toll-like receptors, and TNF signaling proteins, were significantly reduced in RORasg/sg WAT. Moreover, RORasg/sg mice fed with a HFD were protec...

  10. Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages BioProject

    ID: PRJNA179268

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ole for increases in long chain acyl CoA synthase 1 (ACSL1) and diacylglycerol acyltransferase-2 (DGAT2) during the sustained response to TLR2/4 activation; decreases in adipose triglyceride lipase (ATGL, Pnpla2) and monoacylglycerol lipase (MgII) may also contribute. Stimulated murine macrophages that retained TAG carried out phagocytosis more effectively and were protected from saturated fatty acid-induced cell death (lipotoxicity). TLR agonist-induced TAG retention in macrophages is thus an active, sustained process that may have important adaptive functions. It may also contribute to the persistence of lipid-laden macrophages in infected tissues, host susceptibility to some microbial pathogens, and the pathogenesis of atherosclerosis. Overall design: RNA from macrophage loaded with Fatty Acids, stimulated with bacterial lipopolysaccharides (LPS), or both compared to untreated controls (FA, LPS, FA+LPS, untreated). Replicates from 4 independent experiments....
  11. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers BioProject

    ID: PRJNA296032

    Keywords: Epigenomics

    Access Type: download

    dataset.description: licated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1,SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not be blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated to human diseases and traits. Overall design: Bisulphite converted DNA from 355 individuals aged 14-34 were hybridised to the Illumina Infinium 450k Human Methylation Beadchip....
  12. RNA-Seq analysis of glycosylation related gene expression in STZ-induced diabetic rat kidney inner medulla BioProject

    ID: PRJNA285820

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: essed in kidney IM, the glycosyltransferase genes Mgat1, Mgat2, and fucosyltransferase Fut8, did not show any changes. We conclude that the alteration of these glycosylation related genes may contribute to changing the UT-A1 glycan structure, and therefore modulate kidney urea transport activity under diabetic conditions. Overall design: Examination of UT-A1 urea transporter glycosylation related genes under STZ-induced diabetic conditions...
  13. Nuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance BioProject

    ID: PRJNA130775

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ynthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels in liver of RORasg/sg mice. In addition to reduced lipid accumulation, inflammation was greatly diminished in white adipose tissue (WAT) of RORasg/sg mice fed with a HFD. The infiltration of macrophages and the expression of many immune-response and pro-inflammatory genes, including those encoding various chemo/cytokines, toll-like receptors, and TNF signaling proteins, were significantly reduced in RORasg/sg WAT. Moreover, RORasg/sg mice fed with a HFD were protec...
  14. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance BioProject

    ID: PRJNA126821

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: de synthesis and storage, including Cidea, Cidec, Mogat1, and CD36, was greatly decreased in the liver of TAK1-/- mice. Moreover, TAK1-/- mice exhibit reduced infiltration of inflammatory cells and expression of inflammatory genes in adipose tissue and were resistant to the development of glucose intolerance and insulin resistance. TAK1-/- mice consume more oxygen and produce more carbon dioxide than WT mice suggesting a higher rate of energy expenditure. Together, these results indicate that TAK1 plays a critical role in the regulation of energy and lipid homeostasis and potentiates the development of metabolic syndrome. Our study suggests that TAK1 might provide a novel therapeutic target in the management of metabolic syndrome. ...
  15. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance OmicsDI

    ID: E-GEOD-21903

    Date Released: 06-26-2012

    Description: de synthesis and storage, including Cidea, Cidec, Mogat1, and CD36, was greatly decreased in the liver of TAK1-/- mice. Moreover, TAK1-/- mice exhibit reduced infiltration of inflammatory cells and expression of inflammatory genes in adipose tissue and were resistant to the development of glucose intolerance and insulin resistance. TAK1-/- mice consume more oxygen and produce more carbon dioxide than WT mice suggesting a higher rate of energy expenditure. Together, these results indicate that TAK1 plays a critical role in the regulation of energy and lipid homeostasis and potentiates the development of metabolic syndrome. Our study suggests that TAK1 might provide a novel therapeutic target in the management of metabolic syndrome. ...

  16. Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP-2-deoxy-2-fluoro-glucose PDB

    ID: PDB:2AM4

    Description: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (E.C.2.4.1.101)

    gene.name: MGAT1, GNT1
  17. Nuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance OmicsDI

    ID: E-GEOD-23736

    Date Released: 06-26-2012

    Description: ynthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels in liver of RORasg/sg mice. In addition to reduced lipid accumulation, inflammation was greatly diminished in white adipose tissue (WAT) of RORasg/sg mice fed with a HFD. The infiltration of macrophages and the expression of many immune-response and pro-inflammatory genes, including those encoding various chemo/cytokines, toll-like receptors, and TNF signaling proteins, were significantly reduced in RORasg/sg WAT. Moreover, RORasg/sg mice fed with a HFD were protec...

  18. Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP-Glucose PDB

    ID: PDB:2AM3

    Description: "Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP-Glucose"

    gene.name: MGAT1, GNT1
  19. Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with UDP PDB

    ID: PDB:2AM5

    Description: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (E.C.2.4.1.101)

    datasetDistributions.accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=2AM5&bionumber=1
  20. CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINYLTRANSFERASE I PDB

    ID: PDB:1FO9

    Description: STRUCTURE OF N-ACETYLGLUCOSAMINYLTRANSFERASE I

    dataset.keywords: ALPHA-1

Displaying 20 of 25 results for "MOGAT1"