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Displaying 20 of 37 results for "MLLT10"
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  1. MLLT10 gene recombinations in pediatric T-Acute Lymphoblastic Leukemia BioProject

    ID: PRJNA183087

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. MLLT10 gene recombinations in pediatric T-Acute Lymphoblastic Leukemia OmicsDI

    ID: E-GEOD-42765

    Date Released: 06-02-2014

    Description: MLLT10, a 24 exons gene at 10p12, is known in leukemogenesis as partner of MLL or PICALM and recently NAP1L1. We identified HNRNPH1...

  3. EZH2 mutations can be detected in 23% of PICALM-MLLT10 (CALM-AF10) positive acute leukemias ArrayExpress

    ID: E-GEOD-30599

    Description: leukemias are limited. We investigated 13 PICALM-MLLT10 (=CALM-AF10) rearranged acute leukemia predominantly of T-lineage (7 m/6 f; 6–53 years) by deep-sequencing for EZH2mut and identified 3 (23%) EZH2mut carriers: one splice site mutation in exon 14, while two patients had missense mutations in the D1 region of exon 5 which interacts with different DNA methyltransferase genes (but no DNMT3Amut was detected ...

  4. The Leukemia-associated Mllt10/Af10- Dot1l, dedicated b-catenin coactivators essential for intestinal homeostasis BioProject

    ID: PRJNA126101

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. EZH2 mutations can be detected in 23% of PICALM-MLLT10 (CALM-AF10) positive acute leukemias OmicsDI

    ID: E-GEOD-30599

    Date Released: 12-07-2011

    Description: leukemias are limited. We investigated 13 PICALM-MLLT10 (=CALM-AF10) rearranged acute leukemia predominantly of T-lineage (7 m/6 f; 6–53 years) by deep-sequencing for EZH2mut and identified 3 (23%) EZH2mut carriers: one splice site mutation in exon 14, while two patients had missense mutations in the D1 region of exon 5 which interacts with different DNA methyltransferase genes (but no DNMT3Amut was detected ...

  6. MLLT10 gene recombinations in pediatric T-Acute Lymphoblastic Leukemia ArrayExpress

    ID: E-GEOD-42765

    Description: MLLT10, a 24 exons gene at 10p12, is known in leukemogenesis as partner of MLL or PICALM and recently NAP1L1. We identified HNRNPH1...

  7. The Leukemia-associated Mllt10/Af10- Dot1l, dedicated b-catenin coactivators essential for intestinal homeostasis ArrayExpress

    ID: E-GEOD-21367

    Description: proteomics, we identified the leukemia-associated Mllt10/Af10 and the methyltransferase Dot1l, as Tcf4/beta-catenin interactors in mouse small intestinal crypts. Mllt10/Af10-Dot1l, essential for transcription elongation, are recruited to Wnt target genes in a beta-catenin -dependent manner, resulting in H3K79 methylation over their coding regions in vivo in proliferative crypts of mouse small intestine, in colorectal cancer and Wnt-inducible HEK293T cells. Depletion of MLLT10/AF10 in colorectal cancer and Wnt-inducible HEK293T cells followed by expression array analysis identifies MLLT10/AF10 and DOT1L as essential activators dedicated to Wnt target gene regulation. In contrast, previously published b-ca...

  8. The Leukemia-associated Mllt10/Af10- Dot1l, dedicated b-catenin coactivators essential for intestinal homeostasis OmicsDI

    ID: E-GEOD-21367

    Date Released: 05-01-2014

    Description: proteomics, we identified the leukemia-associated Mllt10/Af10 and the methyltransferase Dot1l, as Tcf4/beta-catenin interactors in mouse small intestinal crypts. Mllt10/Af10-Dot1l, essential for transcription elongation, are recruited to Wnt target genes in a beta-catenin -dependent manner, resulting in H3K79 methylation over their coding regions in vivo in proliferative crypts of mouse small intestine, in colorectal cancer and Wnt-inducible HEK293T cells. Depletion of MLLT10/AF10 in colorectal cancer and Wnt-inducible HEK293T cells followed by expression array analysis identifies MLLT10/AF10 and DOT1L as essential activators dedicated to Wnt target gene regulation. In contrast, previously published b-ca...

  9. EZH2 mutations can be detected in 23% of PICALM-MLLT10 (CALM-AF10) positive acute leukemias BioProject

    ID: PRJNA144567

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. AF10.txt Figshare

    ID: doi:10.6084/M9.FIGSHARE.3506372.V1

    Release Date: 08-02-2016

    Description: Additional File 10. Phylip file of the concatenated nucleotide dataset (9711 nt.)

  11. MLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study ArrayExpress

    ID: E-GEOD-19577

    Description: We retrospectively analyzed AML patients enrolled in the AIEOP since 2000, 42 patients with 11q23 rearrangement were analyzed by gene expression profi...

  12. Gene expression profiling of CA10 and NHD13 murine AML ArrayExpress

    ID: E-GEOD-40531

    Description: We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy tran...

  13. MLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study BioProject

    ID: PRJNA122467

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Expression Profiling of a CALM/AF10 leukemia mouse model BioProject

    ID: PRJNA95819

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Gene expression profiling of CA10 and NHD13 murine AML BioProject

    ID: PRJNA174228

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA) ArrayExpress

    ID: E-GEOD-27512

    Description: The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias...

  17. Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA) ArrayExpress

    ID: E-GEOD-27513

    Description: The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias...

  18. Microarray data of mouse MLL-AF10 leukemia cells with or without IKK inhibitor treatment ArrayExpress

    ID: E-GEOD-46250

    Description: MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations, however the upstream signaling path...

  19. Transcription profiling of mouse MLL leukemias (whole BM) ArrayExpress

    ID: E-GEOD-13690

    Description: The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia ...

  20. Microarray data of mouse MLL-AF10 leukemia cells with or without IKK inhibitor treatment BioProject

    ID: PRJNA198509

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 37 results for "MLLT10"