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Displaying 20 of 25 results for "MIR424"
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  1. laryngo-pharyngeal tumor RNA-seq study for both mRNA and miRNA ArrayExpress

    ID: E-GEOD-67994

    Description: tumors. Alongside gene expression, the microRNAs hsa-miR-139, hsa-miR-203 and the hsa-miR-424/503 cluster have aberrant expression in these cancers. Using target genes for these microRNAs, we found the involvement of pathways linked to cell cycle, p53 signaling, and viral carcinogenesis significant ( *P*-values 10-13, 10-9 and 10-7 respectively). Finally, using an ensemble machine-learning tool, we discovered a unique 8-gene signature for this group of cancers that differentiates the group from the other subsites of head and neck. We investigated the role of promoter methylation in one of these genes, WIF1, and found no correlation between DNA methylation and down-regulation of WIF1. We validated our findings of gene expression, 8-gene signature and promoter methylation using q-PCR, data from TCGA and q-MSP respectively. RNA-seq experiments in tumors of larynx and hypopharynx for discovery of gene and miRNA expression Please note that processed data files were not provided since they are available through the journal's website. However a brief description of each processed data is provided in the 'readme.txt'....

  2. laryngo-pharyngeal tumor RNA-seq study for both mRNA and miRNA BioProject

    ID: PRJNA281942

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tumors. Alongside gene expression, the microRNAs hsa-miR-139, hsa-miR-203 and the hsa-miR-424/503 cluster have aberrant expression in these cancers. Using target genes for these microRNAs, we found the involvement of pathways linked to cell cycle, p53 signaling, and viral carcinogenesis significant ( *P*-values 10-13, 10-9 and 10-7 respectively). Finally, using an ensemble machine-learning tool, we discovered a unique 8-gene signature for this group of cancers that differentiates the group from the other subsites of head and neck. We investigated the role of promoter methylation in one of these genes, WIF1, and found no correlation between DNA methylation and down-regulation of WIF1. We validated our findings of gene expression, 8-gene signature and promoter methylation using q-PCR, data from TCGA and q-MSP respectively. Overall design: RNA-seq experiments in tumors of larynx and hypopharynx for discovery of gene and miRNA expression Please note that processed data files were not provided since they are available through the journal's website. However a brief description of each processed data is provided in the ...
  3. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis BioProject

    ID: PRJNA236738

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis OmicsDI

    ID: E-GEOD-54505

    Date Released: 08-25-2015

    Description: ell understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. Further, microRNA-424 in...

  5. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis ArrayExpress

    ID: E-GEOD-54505

    Description: ell understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. Further, microRNA-424 in...

  6. A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma BioProject

    ID: PRJNA342828

    Access Type: download

  7. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis BioProject

    ID: PRJNA252884

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma (NB cell lines) BioProject

    ID: PRJNA335354

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma(NB Samples) BioProject

    ID: PRJNA342484

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. laryngo-pharyngeal tumor RNA-seq study for both mRNA and miRNA OmicsDI

    ID: E-GEOD-67994

    Date Released: 08-19-2015

    Description: tumors. Alongside gene expression, the microRNAs hsa-miR-139, hsa-miR-203 and the hsa-miR-424/503 cluster have aberrant expression in these cancers. Using target genes for these microRNAs, we found the involvement of pathways linked to cell cycle, p53 signaling, and viral carcinogenesis significant ( *P*-values 10-13, 10-9 and 10-7 respectively). Finally, using an ensemble machine-learning tool, we discovered a unique 8-gene signature for this group of cancers that differentiates the group from the other subsites of head and neck. We investigated the role of promoter methylation in one of these genes, WIF1, and found no correlation between DNA methylation and down-regulation of WIF1. We validated our findings of gene expression, 8-gene signature and promoter methylation using q-PCR, data from TCGA and q-MSP respectively. RNA-seq experiments in tumors of larynx and hypopharynx for discovery of gene and miRNA expression Please note that processed data files were not provided since they are available through the journal's website. However a brief description of each processed data is provided in the 'readme.txt'....

  11. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis ArrayExpress

    ID: E-GEOD-58560

    Description: Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during a...

  12. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis OmicsDI

    ID: E-GEOD-58560

    Date Released: 03-08-2015

    Description: Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during a...

  13. MIRnome Profiling of Hereditary Pheochromocytoma and Paraganglioma Reveals Specific Signatures According to Primary Mutation: Possible Implications in... OmicsDI

    ID: E-GEOD-29742

    Date Released: 06-02-2014

    Description: nd progression of PCC/PGL, as well as to identify microRNA biomarkers specifically related to different PCC/PGL genetic classes known so far, we characterized microRNA profiles in a large series of frozen tumors with germline mutations in SDHD, SDHB, VHL, RET, NF1, and TMEM127 genes through microarray analysis. We identified microRNA signatures specific to, as well as common among, the genetic classes of PCC/PGLs, and the best candidate microRNAs (miR-122, miR-126*, miR-129*, miR-133b, miR-137, miR-183, miR-2...

  14. MIRnome Profiling of Hereditary Pheochromocytoma and Paraganglioma Reveals Specific Signatures According to Primary Mutation: Possible Implications in... ArrayExpress

    ID: E-GEOD-29742

    Description: nd progression of PCC/PGL, as well as to identify microRNA biomarkers specifically related to different PCC/PGL genetic classes known so far, we characterized microRNA profiles in a large series of frozen tumors with germline mutations in SDHD, SDHB, VHL, RET, NF1, and TMEM127 genes through microarray analysis. We identified microRNA signatures specific to, as well as common among, the genetic classes of PCC/PGLs, and the best candidate microRNAs (miR-122, miR-126*, miR-129*, miR-133b, miR-137, miR-183, miR-2...

  15. MIRnome Profiling of Hereditary Pheochromocytoma and Paraganglioma Reveals Specific Signatures According to Primary Mutation: Possible Implications in... BioProject

    ID: PRJNA141171

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd progression of PCC/PGL, as well as to identify microRNA biomarkers specifically related to different PCC/PGL genetic classes known so far, we characterized microRNA profiles in a large series of frozen tumors with germline mutations in SDHD, SDHB, VHL, RET, NF1, and TMEM127 genes through microarray analysis. We identified microRNA signatures specific to, as well as common among, the genetic classes of PCC/PGLs, and the best candidate microRNAs (miR-122, miR-126*, miR-129*, miR-133b, miR-137, miR-183, miR-2...
  16. Ovarian Cancer Cell Lines pre-microRNA Transfection BioProject

    ID: PRJNA113075

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. IGROV1 miRNA expression analysis after in vivo locoregional treatment with CpG-ODN ArrayExpress

    ID: E-GEOD-41783

    Description: d mice versus controls. Evaluation of the role of miR-424, miR-340 and miR-302b on cisplatin sensitivity revealed that ectopic expression of miR-302b (up-modulated in our array) in IGROV1 cells significantly improved cisplatin activity. The identification of miRNAs able to modify sensitivity to chemotherapy treatment will provide an experimental base for its future possible use as a target or tool of specific therapies. IGROV1 human ovarian carcinoma cells were adapted to growth intraperitoneally (i.p.) and maintained by serial i...

  18. Genome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop ArrayExpress

    ID: E-GEOD-14685

    Description: them, miRNAs encoded from 2 paralogous clusters, miR-17-92 and miR-106a-363, were up-regulated. In addition, increased expression of miR-424, miR-542-3p and miR-450, located within the same genomic region and down-regulation of miR-181 family members were observed during the estrogenic response. We observed that ERα alone is sufficient for sustained transcription of

  19. Genome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop BioProject

    ID: PRJNA111671

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: them, miRNAs encoded from 2 paralogous clusters, miR-17-92 and miR-106a-363, were up-regulated. In addition, increased expression of miR-424, miR-542-3p and miR-450, located within the same genomic region and down-regulation of miR-181 family members were observed during the estrogenic response. We observed that ERα alone is sufficient for sustained transcription of
  20. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis SRA

    Accession: SRX451749

    Organism: Homo sapiens

    Size: 1859.98


Displaying 20 of 25 results for "MIR424"