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Displaying 20 of 64 results for "MIR126"
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  1. Attenuation of miR-126 activity expands HSC in vivo without exhaustion ArrayExpress

    ID: E-GEOD-40458

    Description: tractive candidate HSC regulators. We report that miR-126, a miRNA expressed in HSC and early progenitors, plays a pivotal role in restraining cell cycle progression of HSC in vitro and in vivo. miR-126 knockdown using lentiviral sponges increased HSC proliferation without inducing exhaustion, resulting in expansion of mouse and human long-term repopulating HSC. Conversely, enforced miR-...

  2. Attenuation of miR-126 activity expands HSC in vivo without exhaustion BioProject

    ID: PRJNA174082

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Attenuation of miR-126 activity expands HSC in vivo without exhaustion OmicsDI

    ID: E-GEOD-40458

    Date Released: 06-02-2014

    Description: tractive candidate HSC regulators. We report that miR-126, a miRNA expressed in HSC and early progenitors, plays a pivotal role in restraining cell cycle progression of HSC in vitro and in vivo. miR-126 knockdown using lentiviral sponges increased HSC proliferation without inducing exhaustion, resulting in expansion of mouse and human long-term repopulating HSC. Conversely, enforced miR-...

  4. Apoptotic bodies unleash functional CXCL12 expression through microRNA-126 BioProject

    ID: PRJNA112707

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. The miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids BioProject

    ID: PRJNA222226

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Primitive erythropoiesis is regulated by miR-126 via non-hematopoietic Vcam-1+ cells BioProject

    ID: PRJNA162881

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Effects of miR-126/126* of cytokine/chemokine expression in tumor-derived 4T1 cells BioProject

    ID: PRJNA183703

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. miR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia BioProject

    ID: PRJNA312538

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Apoptotic bodies unleash functional CXCL12 expression through microRNA-126 ArrayExpress

    ID: E-GEOD-12696

    Description: ression of CXCL12. This is mediated through miRNA-126 enriched in AB, which acts by silencing RGS16 translation and unlocking CXCR4 to unleash an auto-regulatory feedback loop inducing CXCL12. Injection of AB promoted mobilization and incorporation of progenitor cells, reducing diet-induced atherosclerosis in apolipoprotein E-deficient mice, and local transfer of microRNA-126 inhibited collar-induced arterial plaque formation. This was associated with increased smooth muscle content but decreased macrophage and apoptotic cell content, all features of plaque stability. Our data identify a new mechanism, by which AB confer microRNA-126 as a paracrine alarm messenger to enhance CXCR4 signals and CXCL12 expression, thereby limiting or repairing vascular damage. This adds to the important functions of microRNAs in health and disease and may extend to progenitor cell recruitment during other forms of tissue repair or homeostasis. AB we...

  10. Apoptotic bodies unleash functional CXCL12 expression through microRNA-126 OmicsDI

    ID: E-GEOD-12696

    Date Released: 05-01-2014

    Description: ression of CXCL12. This is mediated through miRNA-126 enriched in AB, which acts by silencing RGS16 translation and unlocking CXCR4 to unleash an auto-regulatory feedback loop inducing CXCL12. Injection of AB promoted mobilization and incorporation of progenitor cells, reducing diet-induced atherosclerosis in apolipoprotein E-deficient mice, and local transfer of microRNA-126 inhibited collar-induced arterial plaque formation. This was associated with increased smooth muscle content but decreased macrophage and apoptotic cell content, all features of plaque stability. Our data identify a new mechanism, by which AB confer microRNA-126 as a paracrine alarm messenger to enhance CXCR4 signals and CXCL12 expression, thereby limiting or repairing vascular damage. This adds to the important functions of microRNAs in health and disease and may extend to progenitor cell recruitment during other forms of tissue repair or homeostasis. AB we...

  11. The miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids OmicsDI

    ID: E-GEOD-51255

    Date Released: 07-23-2015

    Description: microRNA-126 is a microRNA predominately expressed by endothelial cells and controls angiogen...

  12. miR-126 Governs Human Leukemia Stem Cell Quiescence and Therapeutic Resistance OmicsDI

    ID: PXD001994

    Date Released: 03-31-2016

    Description: - and loss-of-function analyses demonstrated that miR-126 restrained cell cycle progression, prevented differentiation, and increased self-renewal of human LSC. By targeting the G0 to G1 gatekeeper CDK3, miR-126 preserved LSC quiescence and promoted chemotherapy resistance. Thus, in AML, miRNAs influence patient outcome through post-transcriptional regulation of stemness programs in LSC....

  13. Transcription profiling by array of human melanoma cell lines transfected with miR-126-126* to study the microRNA's role in tumour progression OmicsDI

    ID: E-MEXP-3629

    Date Released: 05-20-2013

    Description: Based on microRNA expression profiling studies, here we focus on miR-126&126* as th...

  14. miR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia OmicsDI

    ID: E-GEOD-78078

    Date Released: 06-18-2016

    Description: MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoie...

  15. Primitive erythropoiesis is regulated by miR-126 via non-hematopoietic Vcam-1+ cells ArrayExpress

    ID: E-GEOD-37727

    Description: cal overexpression/knockout studies, we find that miR-126 regulates the duration of the primitive erythroid program, and confirm this in embryonic miR-

  16. The miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids ArrayExpress

    ID: E-GEOD-51255

    Description: microRNA-126 is a microRNA predominately expressed by endothelial cells and controls angiogen...

  17. Transcription profiling by array of human melanoma cell lines transfected with miR-126-126* to study the microRNA's role in tumour progression ArrayExpress

    ID: E-MEXP-3629

    Description: Based on microRNA expression profiling studies, here we focus on miR-126&126* as th...

  18. Primitive erythropoiesis is regulated by miR-126 via non-hematopoietic Vcam-1+ cells OmicsDI

    ID: E-GEOD-37727

    Date Released: 06-11-2012

    Description: cal overexpression/knockout studies, we find that miR-126 regulates the duration of the primitive erythroid program, and confirm this in embryonic miR-

  19. miR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia ArrayExpress

    ID: E-GEOD-78078

    Description: MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoie...

  20. Suppression of breast tumor growth and metastasis by an engineered transcription factor BioProject

    ID: PRJNA138039

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he ability of the Artificial Transcription Factor 126 (ATF-126) designed to upregulate the Maspin promoter to inhibit tumor progression in pre-established breast tumors in immunodeficient mice. ATF-126 was transduced in the aggressive, mesenchymal-like and triple negative breast cancer line, MDA-MB-231. Induction of ATF expression in vivo by Doxycycline resulted in 50% reduction in tumor growth and totally abolished tumor cell colonization. Genome-wide transcriptional profiles of ATF-induced cells revealed a g...

Displaying 20 of 64 results for "MIR126"