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Displaying 20 of 60 results for "MIR125A"
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  1. Cultured human amniotic fluid-derived mesenchymal stromal cells [miRXplore data] BioProject

    ID: PRJNA155155

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. Overall design: miRNA patterns were studied in in vitro culture samples of human amniotic fluid-derived mesenchymal stromal cells at passages P1, P3, P5 and P10 with miRXplorer microarrays using a synthetic pool of miRNAs. Cell pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and sent to Miltenyi Biotec for their analysis....
  2. Cultured human amniotic fluid-derived mesenchymal stromal cells [PIQOR data] ArrayExpress

    ID: E-GEOD-30064

    Description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. The variations in the expression patterns of the mRNAs were studied using topic-defined PIQOR Stem Cell microarrays. Human amniotic fluid-derived mesenchymal stromal cells pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and send to Miltenyi Biotec for their analysis. A pool of non-stimulated lymphocytes (non-mitotic cell cycle) obtained by Ficoll isolation in the Immunology Service of Carlos Haya hospital was used as a control of the expression....

  3. Cultured human amniotic fluid-derived mesenchymal stromal cells [miRXplore data] ArrayExpress

    ID: E-GEOD-30065

    Description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. miRNA patterns were studied in in vitro culture samples of human amniotic fluid-derived mesenchymal stromal cells at passages P1, P3, P5 and P10 with miRXplorer microarrays using a synthetic pool of miRNAs. Cell pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and sent to Miltenyi Biotec for their analysis....

  4. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency Figshare

    ID: doi:10.6084/M9.FIGSHARE.1486425.V1

    Release Date: 03-11-2016

    Description:

  5. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency Figshare

    ID: doi:10.6084/M9.FIGSHARE.1486425

    Release Date: 03-11-2016

    Description:

  6. Cultured human amniotic fluid-derived mesenchymal stromal cells [PIQOR data] BioProject

    ID: PRJNA155153

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. Overall design: The variations in the expression patterns of the mRNAs were studied using topic-defined PIQOR Stem Cell microarrays. Human amniotic fluid-derived mesenchymal stromal cells pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and send to Miltenyi Biotec for their analysis. A pool of non-stimulated lymphocytes (non-mitotic cell cycle) obtained by Ficoll isolation in the Immunology Service of Carlos Haya hospital was used as a control of the expression....
  7. Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector. BioProject

    ID: PRJNA154197

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Upregulation of pro-apoptotic microRNA mir-125a following massive small bowel resection in rats BioProject

    ID: PRJNA136619

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Genetic Screen Identifies MicroRNA Cluster 99b/let-7e/125a as a Regulator of Primitive Hematopoietic Cells ArrayExpress

    ID: E-GEOD-33691

    Description: 3689: Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector. GSE33690: MicroRNA profiles of ...

  10. Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector. OmicsDI

    ID: E-GEOD-33689

    Date Released: 01-05-2012

    Description: Of special interest was an evolutionary conserved miR-cluster located on chromosome 17 consisting of miR-99b, let-7e and miR-125a. All cluster members were most highly expressed in LSKs and down-regulated upon differentiation. In addition, these microRNAs were higher expressed in DBA/2 cells compared to C57BL/6 cells, and thus correlated with HSPC frequency. To functionally characterize these microRNAs, we overexpressed the entire miR-cluster 99b/let-7e/125a and miR-125a alone in BM cells from C57BL/6 mice. Overexpression of the miR

  11. Genetic Screen Identifies MicroRNA Cluster 99b/let-7e/125a as a Regulator of Primitive Hematopoietic Cells OmicsDI

    ID: E-GEOD-33691

    Date Released: 05-02-2014

    Description: 3689: Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector. GSE33690: MicroRNA profiles of ...

  12. microRNA expression in murine hematopoietic stem cells BioProject

    ID: PRJNA128535

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector ArrayExpress

    ID: E-GEOD-33689

    Description: Of special interest was an evolutionary conserved miR-cluster located on chromosome 17 consisting of miR-99b, let-7e and miR-125a. All cluster members were most highly expressed in LSKs and down-regulated upon differentiation. In addition, these microRNAs were higher expressed in DBA/2 cells compared to C57BL/6 cells, and thus correlated with HSPC frequency. To functionally characterize these microRNAs, we overexpressed the entire miR-cluster 99b/let-7e/125a and miR-125a alone in BM cells from C57BL/6 mice. Overexpression of the miR

  14. Sensitivity of cholangiocarcinoma cells to gemcitabine is affected by microRNA expression ArrayExpress

    ID: E-GEOD-47396

    Description: n of each of three downregulated miRNAs in HuH28 (miR-29b, miR-205, miR-221) restored Gem sensitivity to HuH28. Suppression of one upregulated miRNA in HuH28, miR-125a-5p, inhibited HuH28 cell proliferation independently to Gem treatment. Cell lines and cultures Two human intrahepatic CCA cell lines, HuCCT1 and HuH28, were purchased from Japan Health Science Research Resources Bank (Osaka, Japan). Each cell line was cultured in RPMI-1640 medium (Invitrogen, Life Technologies Corp., CA, USA) that contained 10% fetal bovine serum (Nichirei Bioscience, ...

  15. Cultured human amniotic fluid-derived mesenchymal stromal cells [miRXplore data] OmicsDI

    ID: E-GEOD-30065

    Date Released: 05-02-2014

    Description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. miRNA patterns were studied in in vitro culture samples of human amniotic fluid-derived mesenchymal stromal cells at passages P1, P3, P5 and P10 with miRXplorer microarrays using a synthetic pool of miRNAs. Cell pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and sent to Miltenyi Biotec for their analysis....

  16. MicroRNA profiles of four developmentally related hematopoietic cell types isolated from the BM of B6 and D2 mice. BioProject

    ID: PRJNA154199

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Cultured human amniotic fluid-derived mesenchymal stromal cells [PIQOR data] OmicsDI

    ID: E-GEOD-30064

    Date Released: 05-02-2014

    Description: down-regulation of TP53, increased expression of hsa-miR-125a and up-regulation of CDKN2D. The variations in TP53 and hsa-miR-125a may act as an indicator of the stemness of the hAMSC, whereas CDKN2D may indicate the reduction in the proliferative capacity of these cells in a TP53-independent mechanism. The genes described in this study will help evaluate the fitness of hAMSC, thus guaranteeing their biological quality for use in regenerative medicine. The variations in the expression patterns of the mRNAs were studied using topic-defined PIQOR Stem Cell microarrays. Human amniotic fluid-derived mesenchymal stromal cells pellets of 5 x 10E5 cells were cryopreserved in liquid nitrogen and send to Miltenyi Biotec for their analysis. A pool of non-stimulated lymphocytes (non-mitotic cell cycle) obtained by Ficoll isolation in the Immunology Service of Carlos Haya hospital was used as a control of the expression....

  18. microRNA expression in murine hematopoietic stem cells OmicsDI

    ID: E-GEOD-22450

    Date Released: 03-27-2012

    Description: on the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential for stem cell persistence in vivo and a specific microRNA, miR-125a controls the size of the stem cell population by r...

  19. Upregulation of pro-apoptotic microRNA mir-125a following massive small bowel resection in rats ArrayExpress

    ID: E-GEOD-26542

    Description: Upregulation of mir-125a suppresses the pro-survival protein Mcl1, producing the increase in apoptosis known to accompany the pr...

  20. EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions [mi... BioProject

    ID: PRJNA345622

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: roRNAs with tumor suppressor functions; primarily miR125a-3p and miR320c. Using chromatin immunoprecipitation (ChIP) we demonstrate that miR125a-3p and miR320c are targets of EZH2 and H3K27me3 in MM cell lines and primary MM cells. Our results further highlight the importance of polycomb-mediated silencing in MM to include microRNAs with tumor suppressor activity. This novel role further strengthens the oncogenic features of EZH2 and its potential as a therapeutic target in MM. Overall design: 4 biological replicates with 8 samples were used in the study. The controls were treated with DMSO while the treatment was done using EZH2 inhibitor UNC1999. The anti-myeloma effects exerted by EZH2 inhibition was investigated using UNC1999, small specific inhibitor of EZH2, at 120 hours post-treament by analyzing global changes in mRNA and miRNA expression...

Displaying 20 of 60 results for "MIR125A"