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Displaying 2 of 2 results for "MCTP1"
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  1. Expression data from A2780 cell line and wild type ovarian cancer cell line (with resistant sublines) BioProject

    ID: PRJNA298550

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ownregulated expression of ABCC6, BST2, ERAP2 and MCTP1; in the Pac-resistant cell line, we observe upregulated expression of ABCB1, EPHA7 and RUNDC3B and downregulated expression of LIPG, MCTP1, NSBP1, PCDH9, PTPRK and SEMA3A. The expression levels of three genes, ABCB1, ABCB4 and IFI16, were upregulated in the Dox-resistant cell lines. In the Top-resistant cell lines, we observed increased expression levels of ABCG2, HERC5, IFIH1, MYOT, S100A3, SAMD4A, SPP1 and TGFBI and decreased expression levels of MCTP1 and PTPRK Overall design: In this study, we used two ovarian cancer cell lines, the established ovarian cancer A2780 cell line and the primary ovarian cancer W1 cell line. The human ovarian carcinoma A2780 cell line was purchased from ATCC. A2780 sublines that were resistant to CisPt [A2780CR1 and A2780CR2 (A2780 cisplatin resistant)], Pac [A2780PR1 and A2780PR2 (A2780 paclitaxel resistant)], Dox [A2780DR1 and A2780DR2 (A2780 doxorubicin resistant)] and Top [A2780TR1 and A2780TR2 (A2780 topotecan resistant)] were generated by exposing A2780 cells to the relevant drugs at incrementally increased concentrations. The human ovarian cancer W1 cell line was established using ovarian cancer tissue obtained from an untreated patient. W1 sublines resistant to CisPt [W1CR (W1 cisplatin resistant)], Dox [W1DR (W1 doxorubicin resistant)], Top [W1TR (W1 topotecan resistant)], Met [W1MR (W1 methotrexate resisntant)], Vin [W1VR (W1 vincristine resistant)] and Pac [W1PR (W1 paclitaxel resistant)] were obtained by exposing W1 cells to the drugs at incrementally increased concentrations....
  2. Genes regulated by high calcium medium in parathyroid tissue explants from patients with primary hyperparathyroidism BioProject

    ID: PRJNA121569

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: re than 30 genes were down-regulated by more than 1/2 in PTEs obtained from patients with I-HPT. Interestingly, 9 of these genes (up-regulated genes: chemokine ligand 8[CCL8], multiple C2 domain and transmembrane region protein 1 [MCTP1]; down-regulated genes: matrix metallopeptidase-9 [MMP9], B-box and SPRY domain-containing protein [BSPRY], nitric oxide synthase 2A [NOS2A], parathyroid hormone [PTH], cartilage acidic protein 1 [CRTAC1], chromogranin A [CHGA], and fibrin 1 [FBLN1]) were involved in calcium metabolism or calcium-signaling pathways in the parathyroid tissue. Unexpectedly, however, the expression level of mRNA for alpha-klotho was variable, and it was not constantly decreased in hypercalcemic medium under the present experimental conditions. Although it was not possible to use norma...

Displaying 2 of 2 results for "MCTP1"