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Displaying 20 of 36 results for "MAP2K5"
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  1. en Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)... PDB

    ID: PDB:2O2V

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2), Mitogen-activated protein kinase kinase kinase 3 (E.C.2.7.11.25)

  2. en activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)... PDB

    ID: PDB:2NPT

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2), Mitogen-activated protein kinase kinase kinase 2 (E.C.2.7.11.25)

  3. Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5) PDB

    ID: PDB:1WI0

    Description: mitogen activated protein kinase kinase 5

  4. Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment PDB

    ID: PDB:4IC7

    Description: Mitogen-activated protein kinase 7 (E.C.2.7.11.24), Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2)

    gene.name: MAP2K5, MEK5, MKK5, PRKMK5
  5. MK07_BOVIN UniProt:Swiss-Prot

    ID: A5PKJ4

    Description: for cytoplasmic targeting Required for binding to MAP2K5 Necessary for oligomerization May not be required for kinase activity; required to stimulate MEF2C activity TXY Nuclear localization signal Pro-rich Arg-rich Pro-rich Proton acceptor ATP N-acetyl...

  6. MK07_RAT UniProt:Swiss-Prot

    ID: P0C865

    Description: for cytoplasmic targeting Required for binding to MAP2K5 Necessary for oligomerization May not be required for kinase activity; required to stimulate MEF2C activity TXY Nuclear localization signal Pro-rich Arg-rich Pro-rich Proton acceptor ATP N-acetyl...

  7. Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5) BMRB

    ID: 10046

    Creator: Yoneyama, M. Hayashi, F. Tochio, N. Koshiba, S. Inoue, M. Kigawa, T. Yokoyama, S.

    Release Date: 12-07-2007

  8. MEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells ArrayExpress

    ID: E-GEOD-25145

    Description: MEK5 is activated by shear stress in large vessel endothelial cells (ECs) and contributes to the suppression of pro-inflammatory changes in the arteri...

  9. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers ArrayExpress

    ID: E-GEOD-73103

    Description: HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1,SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not be blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated to human diseases and traits. Bisulphite converted DNA from 355 individuals aged 14-34 were hybridised to the Illumina Infinium 450k Human Methylation Beadchip....

  10. MEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells BioProject

    ID: PRJNA134487

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers BioProject

    ID: PRJNA296032

    Keywords: Epigenomics

    Access Type: download

    dataset.description: HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1,SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not be blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated to human diseases and traits. Overall design: Bisulphite converted DNA from 355 individuals aged 14-34 were hybridised to the Illumina Infinium 450k Human Methylation Beadchip....
  12. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers OmicsDI

    ID: E-GEOD-73103

    Date Released: 09-19-2015

    Description: HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1,SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not be blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated to human diseases and traits. Bisulphite converted DNA from 355 individuals aged 14-34 were hybridised to the Illumina Infinium 450k Human Methylation Beadchip....

  13. Transcription profiling by array of hearts from PKCzeta knock out mice ArrayExpress

    ID: E-GEOD-29145

    Description: Background: Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of cardiovascular fun...

  14. Array-comparative genomic hybridization by using DualChip® human cancer 1.1 arrays BioProject

    ID: PRJNA106835

    Keywords: Variation

    Access Type: download

    dataset.description: KDR, KISS1, LIF, MIF, MMP11, MMP14, MDH1, MAP2K1, MAP2K5, MAPK10, MAPK14, MCL1, NF2, NID1, NINJ1, NRG1, NTRK1, PGF, PDGFB, PDGFRA, PLAT, PLG, PDCD2, PPBP, PRODH, PTGES, PCDH1, PTK2, PURA, QSCN6, RIPK1, RRM1, ARHGDIA, SFRP2, SOD1, STAT1, TEK, TERT, THBS1, TIAM1, TNC, TANK, TGFA, TGFB2, XRCC6, TGFB3, TGFBR1, TMED10, TPBG, TYRO3, ERBB4, FLT4, FOS, VIL2)....
  15. 2290148 RGD

    Description: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb

    Creators: PGA

    biologicalEntity.identifiers: F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi
  16. Novel Roles fro ERK5 and Cofiin as Critical Mediators Linking Estrogen Receptor α-Driven Transcription, Actin Reorganization and Invasiveness in Brea... ArrayExpress

    ID: E-GEOD-53394

    Description: Cancer cell motility and invasiveness are fundamental characteristics of the malignant phenotype and are regulated through diverse signaling networks ...

  17. PF-3758309 KiNativ -- single dose experiment LINCS

    Data Type: Binding Protein binding profile

    Assay: KiNativ kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1259

    protein.name: MAP2K5
  18. QL-X-138 KiNativ -- single dose experiment LINCS

    Data Type: Binding Protein binding profile

    Assay: KiNativ kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1185

    protein.name: MAP2K5
  19. Novel Roles for ERK5 and Cofiin as Critical Mediators Linking Estrogen Receptor α-Driven Transcription, Actin Reorganization and Invasiveness in Brea... BioProject

    ID: PRJNA231915

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. GW-5074 KiNativ -- dose response experiment LINCS

    Data Type: Binding Protein binding profile

    Assay: KiNativ kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1074

    protein.name: MAP2K5

Displaying 20 of 36 results for "MAP2K5"