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Displaying 20 of 45 results for "LYL1"
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  1. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL BioProject

    ID: PRJNA213188

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL OmicsDI

    ID: E-GEOD-49164

    Date Released: 06-03-2014

    Description: To determine the requirement for Lyl1 in Lmo2-driven T-ALL, microarray data was perepared from sorted CD4-CD8 double negative thymocytes of wild-type, Lmo2 transgen...

  3. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL ArrayExpress

    ID: E-GEOD-49164

    Description: To determine the requirement for Lyl1 in Lmo2-driven T-ALL, microarray data was perepared from sorted CD4-CD8 double negative thymocytes of wild-type, Lmo2 transgen...

  4. SCL and LMO1 reprogram thymocytes into self-renewing cells. BioProject

    ID: PRJNA301090

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cription of a self-renewal program coordinated by LYL1. Overall design: Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes....
  5. SCL and LMO1 reprogram thymocytes into self-renewing cells ArrayExpress

    ID: E-GEOD-74659

    Description: cription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes....

  6. Gene expression signatures of 64 T-ALL patient diagnosis samples BioProject

    ID: PRJNA263302

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: c T-ALL transcription factor oncogenes, including LYL1/MEF2C, HOXA, TLX1, TLX3 and TAL1/LMO2. Notably, the recently described Early T-cell Precursor ALL (ETP-ALL) patients have leukemic cells that show an early block in T-cell differentiation and significantly overlap with LYL1-positive T-ALL and MEF2C-dysregulated immature T-ALL. We studied the gene expression profiles of 64 primary T-ALL samples and found a high BCL-2 expression in immature T-ALL patients compared to patients bel...
  7. Genome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq] BioProject

    ID: PRJNA268021

    Keywords: Epigenomics

    Access Type: download

    dataset.description: actors. Overall design: Examination of JMJD1C and LYL1 chromatin binding in Kasumi-1 cells, HL-60 cells, NB-4 cells and THP-1 cells, including ChIP-seqs of JMJD1C and LYL1, and input DNAs for Kasumi-1, HL-60, NB4....
  8. Genome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq] ArrayExpress

    ID: E-GEOD-63484

    Description: transcription factors. Examination of JMJD1C and LYL1 chromatin binding in Kasumi-1 cells, HL-60 cells, NB-4 cells and THP-1 cells, including ChIP-seqs of JMJD1C and LYL1, and input DNAs for Kasumi-1, HL-60, NB4....

  9. Gene expression signatures of 64 T-ALL patient diagnosis samples ArrayExpress

    ID: E-GEOD-62156

    Description: c T-ALL transcription factor oncogenes, including LYL1/MEF2C, HOXA, TLX1, TLX3 and TAL1/LMO2. Notably, the recently described Early T-cell Precursor ALL (ETP-ALL) patients have leukemic cells that show an early block in T-cell differentiation and significantly overlap with LYL1-positive T-ALL and MEF2C-dysregulated immature T-ALL. We studied the gene expression profiles of 64 primary T-ALL samples and found a high BCL-2 expression in immature T-ALL patients compared to patients bel...

  10. A Stable Transcription Factor Complex Nucleated by Dimeric AML1-ETO Controls Leukaemogenesis BioProject

    ID: PRJNA187930

    Keywords: Other

    Access Type: download

    dataset.description: ch AETFC component, including AML1-ETO, HEB, E2A, LYL1, LDB1 and LMO2, and double-knockdown of HEB and E2A, in Kasumi-1 cells. ChIP-seq analyses of four AETFC components, namely AML1-ETO, HEB, E2A and LMO2, in Kasumi-1 cells....
  11. Gene expression signature of the T-ALL cell line LOUCY treated with 1µM (+)-JQ1 for 48h BioProject

    ID: PRJNA323424

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: C, LMO1, LMO2, BCL2, IGFBP7, ZEB2, GFI1B, MYB and LYL1. Overall design: LOUCY cells were treated with 1µM (+)-JQ1 or DMSO for 48h. Three biological replicates of this treatment were performed....
  12. The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myel... ArrayExpress

    ID: E-GEOD-60477

    Description: ontext of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LNMO2, RUNX1 and TAL1) central to proper expression of genes involved in maintaining a stem cell hematopoietic phenotype. Moreover, in t(16;21) FUS-ERG co-occupies genomic regions bound by the nuclear receptor heterodimer RXR-RARA inhibiting target gene expression and interfering with hematopoietic differentiation. All-Trans Retinoic Acid treatment of t(16;21) cells as well as FUS-ERG knock down alleviate the myeloid...

  13. A Stable Transcription Factor Complex Nucleated by Dimeric AML1-ETO Controls Leukaemogenesis ArrayExpress

    ID: E-GEOD-43834

    Description: ch AETFC component, including AML1-ETO, HEB, E2A, LYL1, LDB1 and LMO2, and double-knockdown of HEB and E2A, in Kasumi-1 cells. ChIP-seq analyses of four AETFC components, namely AML1-ETO, HEB, E2A and LMO2, in Kasumi-1 cells....

  14. LYL1_RAT UniProt:Swiss-Prot

    ID: Q66HH3

    Description: Protein lyl-1 bHLH Phosphoserine

    gene.name: Lyl1
  15. Genome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq] OmicsDI

    ID: E-GEOD-63484

    Date Released: 12-02-2015

    Description: transcription factors. Examination of JMJD1C and LYL1 chromatin binding in Kasumi-1 cells, HL-60 cells, NB-4 cells and THP-1 cells, including ChIP-seqs of JMJD1C and LYL1, and input DNAs for Kasumi-1, HL-60, NB4....

  16. Gene expression signatures of 64 T-ALL patient diagnosis samples OmicsDI

    ID: E-GEOD-62156

    Date Released: 10-19-2014

    Description: c T-ALL transcription factor oncogenes, including LYL1/MEF2C, HOXA, TLX1, TLX3 and TAL1/LMO2. Notably, the recently described Early T-cell Precursor ALL (ETP-ALL) patients have leukemic cells that show an early block in T-cell differentiation and significantly overlap with LYL1-positive T-ALL and MEF2C-dysregulated immature T-ALL. We studied the gene expression profiles of 64 primary T-ALL samples and found a high BCL-2 expression in immature T-ALL patients compared to patients bel...

  17. Genome-wide Analysis of Transcriptional Regulators in Human Blood Stem/Progenitor Cells reveals a densely interconnected network of coding and non-cod... ArrayExpress

    ID: E-GEOD-45144

    Description: s of seven key TFs (FLI1, ERG, GATA2, RUNX1, SCL, LYL1 and LMO2) in human CD34+ HSPCs together with quantitative RNA and microRNA expression profiles. We catalogue binding of TFs at coding genes and microRNA promoters and report that combinatorial binding of all seven TFs is favoured and is associated with differential expression of genes and microRNA in HSPCs. We also uncover a hitherto unrecognized association between FLI1 and RUNX1 pairing in HSPCs, establish a correlation between the density of histone modifications, which mark active enhancers and the number of overlapping TFs at a peak and identify complex relationships between specific miRNAs and coding genes regulated by the heptad. ...

  18. The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myel... BioProject

    ID: PRJNA258377

    Keywords: Other

    Access Type: download

    dataset.description: ontext of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LNMO2, RUNX1 and TAL1) central to proper expression of genes involved in maintaining a stem cell hematopoietic phenotype. Moreover, in t(16;21) FUS-ERG co-occupies genomic regions bound by the nuclear receptor heterodimer RXR-RARA inhibiting target gene expression and interfering with hematopoietic differentiation. All-Trans Retinoic Acid treatment of t(16;21) cells as well as FUS-ERG knock down alleviate the myeloid...
  19. Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis BioProject

    ID: PRJNA267254

    Keywords: Other

    Access Type: download

    dataset.description: ell-expressed transcription factor heptad (GATA2, LYL1, TAL1, FLI1, ERG, RUNX1, LMO2) binding to MEG-associated cis-regulatory modules (CRMs) in multipotential progenitors. This is followed by genome-wide GATA factor switching that mediates further induction of MEG-specific genes following lineage commitment. Interaction between GATA and ETS factors appears to be a key determinant of these processes. In contrast, ERY-specific lineage priming is biased toward GATA2-independent mechanisms. In addition to its role in MEG lineage priming, GATA2 plays an extensive role in late megakaryopoiesis as a transcriptional repressor at loci defined by a specific DNA signature. Our findings reveal important new insights into how ERY and MEG lineages arise from a common bipotential progenitor via overlapping and divergent functions of shared hematopoie...
  20. Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis BioProject

    ID: PRJNA214682

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ell-expressed transcription factor heptad (GATA2, LYL1, SCL/TAL1, FLI1, ERG, RUNX1, LMO2) binding to MEG-specific cis-regulatory modules in multipotential hematopoietic progenitors. This is followed by genome-wide GATA factor switching that mediates further induction of MEG-specific genes following lineage commitment. Interaction between GATA and ETS factors appears to be a key determinant of these processes. In contrast, ERY-specific lineage priming occurs is biased toward GATA2-independent mechanisms. In addition to its role in MEG lineage priming, GATA2 plays an extensive role in late megakaryopoiesis as a transcriptional repressor at loci defined by a specific DNA signature. Our findings reveal important new insights into how ERY and MEG lineages arise from a common bipotential precursor via overlapping and divergent f...

Displaying 20 of 45 results for "LYL1"