LOXL4 | bioCADDIE Data Discovery Index
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Displaying 14 of 14 results for "LOXL4"
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  1. LOXL4_BOVIN UniProt:Swiss-Prot

    ID: Q8MJ24

    Description: Lysyl oxidase homolog 4 SRCR 1 SRCR 2 SRCR 3 SRCR 4 Lysyl

  2. LOXL2_XENLA UniProt:Swiss-Prot

    ID: Q08B63

    Description: Lysyl oxidase homolog 2 SRCR 1 SRCR 2 SRCR 3 SRCR 4 Lysyl-

  3. LOXL2_PONAB UniProt:Swiss-Prot

    ID: Q5RFQ6

    Description: Lysyl oxidase homolog 2 SRCR 1 SRCR 2 SRCR 3 SRCR 4 Lysyl-

  4. LOXL1_BOVIN UniProt:Swiss-Prot

    ID: Q95L39

    Description: Lysyl oxidase homolog 1 Lysyl-oxidase like Copper Coppe...

  5. LYOX_MOUSE UniProt:Swiss-Prot

    ID: P28301

    Description: Protein-lysine 6-oxidase Lysyl-oxidase like Copper Copper Copper 2',4',5...

  6. LYOX_RAT UniProt:Swiss-Prot

    ID: P16636

    Description: Protein-lysine 6-oxidase Lysyl-oxidase like Copper Copper Copper 2',4',5...

  7. LYOX_CHICK UniProt:Swiss-Prot

    ID: Q05063

    Description: Protein-lysine 6-oxidase Lysyl-oxidase like Arg/Pro-rich Copper Copper Copper 2',<

  8. LOXs in invasive trophoblasts ArrayExpress

    ID: E-GEOD-28426

    Description: ed in liver cancer 1 (DLC1), dipeptidyl peptidase 4 (DPP4), heme oxygenase 1 (HMOX-1), lysyl oxidase (LOX), plasminogen activator inhibitor 1 (PAI-1) and PPARG. Among the upregulated genes, lysyl oxidase (LOX) was further analyzed. In the LOX family, only LOX, LOXL1 and LOXL2 mRNA expression was significantly upregulated in rosiglitazone-treated EVCTs. RNA and protein expression of the subfamily members LOX, LOXL1 and LOXL2 were analyzed by absolute RT-qPCR and western blotting, and localized by immunohistochemistry and immunofluorescence-confocal microscopy. LOX protein was immunodetected in the EVCT cytoplasm, while LOXL1 was found in the nucleus and nucleolus. No signal was detected for LOXL2 protein. Specific inhibition of LOX activity by beta-aminopropionitrile in cell invasion assays led to an increase in EVCT invasiveness. These results suggest that LOX, LOXL1 and LOXL2 are downstream PPARG targets and that LOX activity is a negative regulator of trophoblastic cell invasion. M...

  9. LOXs in invasive trophoblasts OmicsDI

    ID: E-GEOD-28426

    Date Released: 06-02-2014

    Description: ed in liver cancer 1 (DLC1), dipeptidyl peptidase 4 (DPP4), heme oxygenase 1 (HMOX-1), lysyl oxidase (LOX), plasminogen activator inhibitor 1 (PAI-1) and PPARG. Among the upregulated genes, lysyl oxidase (LOX) was further analyzed. In the LOX family, only LOX, LOXL1 and LOXL2 mRNA expression was significantly upregulated in rosiglitazone-treated EVCTs. RNA and protein expression of the subfamily members LOX, LOXL1 and LOXL2 were analyzed by absolute RT-qPCR and western blotting, and localized by immunohistochemistry and immunofluorescence-confocal microscopy. LOX protein was immunodetected in the EVCT cytoplasm, while LOXL1 was found in the nucleus and nucleolus. No signal was detected for LOXL2 protein. Specific inhibition of LOX activity by beta-aminopropionitrile in cell invasion assays led to an increase in EVCT invasiveness. These results suggest that LOX, LOXL1 and LOXL2 are downstream PPARG targets and that LOX activity is a negative regulator of trophoblastic cell invasion. M...

  10. LOXs in invasive trophoblasts BioProject

    ID: PRJNA139157

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed in liver cancer 1 (DLC1), dipeptidyl peptidase 4 (DPP4), heme oxygenase 1 (HMOX-1), lysyl oxidase (LOX), plasminogen activator inhibitor 1 (PAI-1) and PPARG. Among the upregulated genes, lysyl oxidase (LOX) was further analyzed. In the LOX family, only LOX, LOXL1 and LOXL2 mRNA expression was significantly upregulated in rosiglitazone-treated EVCTs. RNA and protein expression of the subfamily members LOX, LOXL1 and LOXL2 were analyzed by absolute RT-qPCR and western blotting, and localized by immunohistochemistry and immunofluorescence-confocal microscopy. LOX protein was immunodetected in the EVCT cytoplasm, while LOXL1 was found in the nucleus and nucleolus. No signal was detected for LOXL2 protein. Specific inhibition of LOX activity by beta-aminopropionitrile in cell invasion assays led to an increase in EVCT invasiveness. These results suggest that LOX, LOXL1 and LOXL2 are downstream PPARG targets and that LOX activity is a negative regulator of trophoblastic cell invasion. M...
  11. Time course of gene expression signatures in mPTECs during ex vivo culture ArrayExpress

    ID: E-GEOD-69217

    Description: rray and experimental data revealed that Krüppel-like factor 5 (Klf5) was the most upregulated transcription factor accompanied by Krüppel-like factor 4 (Klf4) downregulation when cells on stiff matrix. These changes were reversed by soft matrix via ERK inactivation. Knockdown of Klf5 or forced-expression of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, suggesting that Klf5/Klf4 act as positive/negative regulators, respectively. Moreover, stiff matrix-activated ERK increased the protein level and nuclear translocation of mechanosensitive Yes-associated protein 1 (YAP1), which is reported to prevent Klf5 degradation. Finally, in vivo model of unilateral ureteral obstruction (UUO) revealed that matrix stiffness-regulated Klf5/Klf4 is related to the pathogenesis of renal fibrosis. In the dilated tubules of obstructed kidney, ERK/YAP1/Klf5/Cyclin D1 axis were upregulated and Klf4 was downregulated. Inhibition of collagen crosslinking by lysyl oxidase inhibitor alle...

  12. LOXL2_CHICK UniProt:Swiss-Prot

    ID: E1C3U7

    Description: Lysyl oxidase homolog 2 SRCR 1 SRCR 2 SRCR 3 SRCR 4 Lysyl-

  13. Time course of gene expression signatures in mPTECs during ex vivo culture OmicsDI

    ID: E-GEOD-69217

    Date Released: 08-19-2015

    Description: rray and experimental data revealed that Krüppel-like factor 5 (Klf5) was the most upregulated transcription factor accompanied by Krüppel-like factor 4 (Klf4) downregulation when cells on stiff matrix. These changes were reversed by soft matrix via ERK inactivation. Knockdown of Klf5 or forced-expression of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, suggesting that Klf5/Klf4 act as positive/negative regulators, respectively. Moreover, stiff matrix-activated ERK increased the protein level and nuclear translocation of mechanosensitive Yes-associated protein 1 (YAP1), which is reported to prevent Klf5 degradation. Finally, in vivo model of unilateral ureteral obstruction (UUO) revealed that matrix stiffness-regulated Klf5/Klf4 is related to the pathogenesis of renal fibrosis. In the dilated tubules of obstructed kidney, ERK/YAP1/Klf5/Cyclin D1 axis were upregulated and Klf4 was downregulated. Inhibition of collagen crosslinking by lysyl oxidase inhibitor alle...

  14. Time course of gene expression signatures in mPTECs during ex vivo culture BioProject

    ID: PRJNA284917

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rray and experimental data revealed that Krüppel-like factor 5 (Klf5) was the most upregulated transcription factor accompanied by Krüppel-like factor 4 (Klf4) downregulation when cells on stiff matrix. These changes were reversed by soft matrix via ERK inactivation. Knockdown of Klf5 or forced-expression of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, suggesting that Klf5/Klf4 act as positive/negative regulators, respectively. Moreover, stiff matrix-activated ERK increased the protein level and nuclear translocation of mechanosensitive Yes-associated protein 1 (YAP1), which is reported to prevent Klf5 degradation. Finally, in vivo model of unilateral ureteral obstruction (UUO) revealed that matrix stiffness-regulated Klf5/Klf4 is related to the pathogenesis of renal fibrosis. In the dilated tubules of obstructed kidney, ERK/YAP1/Klf5/Cyclin D1 axis were upregulated and Klf4 was downregulated. Inhibition of collagen crosslinking by lysyl oxidase inhibitor alle...

Displaying 14 of 14 results for "LOXL4"