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Displaying 20 of 33 results for "LMX1A"
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  1. LMX1A_MOUSE UniProt:Swiss-Prot

    ID: Q9JKU8

    Description: LIM homeobox transcription factor 1-alpha

  2. EH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2 BioProject

    ID: PRJNA196515

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. EH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons BioProject

    ID: PRJNA170140

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. EH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons OmicsDI

    ID: E-GEOD-39174

    Date Released: 06-02-2014

    Description: The LIM homeodomain transcription factor Lmx1a is a very potential inducer of ...

  5. EH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons ArrayExpress

    ID: E-GEOD-39174

    Description: The LIM homeodomain transcription factor Lmx1a is a very potential inducer of ...

  6. LMX1A_MESAU UniProt:Swiss-Prot

    ID: Q04650

    Description: LIM homeobox transcription factor 1-alpha

  7. EH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2 ArrayExpress

    ID: E-GEOD-45831

    Description: A) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA develo...

  8. EH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2 OmicsDI

    ID: E-GEOD-45831

    Date Released: 06-03-2014

    Description: A) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA develo...

  9. Single-cell RNA Sequencing Uncovers A Close Relationship Between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages BioProject

    ID: PRJNA343425

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: A sequencing of cells expressing the mesDA neuron transcription factor determinant Lmx1a. This approach resolved the differentiation of mesDA and neighboring neuronal lineages and revealed a remarkably close relationship between developing mesDA and subthalamic nucleus (STN) neurons. The combined ablation of Lmx1a and Lmx1b in mice disrupted both STN and mesDA neural development, while a distinct transcription factor set defined progenitors developing into STN neu...
  10. Purification of functional human ES/iPSC-derived midbrain dopaminergic progenitors using LRTM1 BioProject

    ID: PRJNA295231

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tion strategy for cells expressing both CORIN and LMX1A::GFP and report a novel cell surface marker to enrich mDA progenitors, LRTM1. When transplanted into 6-OHDA-lesioned rats, human iPSC-derived LRTM1+ cells survived and differentiated into mDA neurons in vivo, resulting in significant improvement in motor behavior without tumor formation. In addition, LRTM1+ cells exhibited efficient survival of mDA neurons in the brain of an MPTP-treated monkey. Thus, LRTM1 can provide a powerful tool for efficient and safe cell therapy for PD patients. Overall design: Differentiated mouse ESC-derived neural progenitors just after sorting (day9 CORIN+
  11. Cell cycle and P53 gate the direct conversion of human fibroblasts to dopaminergic neurons BioProject

    ID: PRJNA227463

    Keywords: Variation

    Access Type: download

    dataset.description: human fibroblasts to iDA neurons bt Ascl1, Nurr1, Lmx1a and miR-124. Overall design: MRC-5 cells were used as control, iN cells generated from MRC-5 were analyzed....
  12. Transcriptome analysis of human immortilized astrocytes reprogrammed into dopaminergic neurons BioProject

    ID: PRJNA360999

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ergic neurons (iDAs). This process requires three transcription factors, NEUROD1, ASCL1 and LMX1A as well as one microRNA, mir218. This combined protocol gives rise to human astrocyte-derived iDAs with appropriate midbrain markers as de...
  13. Identification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population ArrayExpress

    ID: E-GEOD-33839

    Description: , KCNV1, ECEL1, TMEM26, TAL1, PROX1, SLC6A20, and LMX1A) capable of differentiating BCa from normal control. Subsequent validation in a large sample size enabled the optimisation of 5 methylation targets (VAX1, KCNV1, TAL1, PPOX1 and CFTR) for BCa diagnosis with sensitivity and specificity of 86.32% and 87.13%, respectively. In addition, VAX1 and LMX1A methylation could predict the tumour recurrence. Conclusions: Tumor specific biomarkers of BCa could be established by first performing genome level methylation profiling with cell lines and then screening the potential targets in urine samples. The panel of methylated genes identified was promising for the early non-invasive detection and surveillance of BCa. MBD methylCap/seq was carried out to screen differentially methylated CpG islands using two BCa cell lines (5637 and T24), and two normal bladder tissue mix as control....

  14. Ascl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state ArrayExpress

    ID: E-GEOD-27174

    Description: Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopi...

  15. Identification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population OmicsDI

    ID: E-GEOD-33839

    Date Released: 06-25-2012

    Description: , KCNV1, ECEL1, TMEM26, TAL1, PROX1, SLC6A20, and LMX1A) capable of differentiating BCa from normal control. Subsequent validation in a large sample size enabled the optimisation of 5 methylation targets (VAX1, KCNV1, TAL1, PPOX1 and CFTR) for BCa diagnosis with sensitivity and specificity of 86.32% and 87.13%, respectively. In addition, VAX1 and LMX1A methylation could predict the tumour recurrence. Conclusions: Tumor specific biomarkers of BCa could be established by first performing genome level methylation profiling with cell lines and then screening the potential targets in urine samples. The panel of methylated genes identified was promising for the early non-invasive detection and surveillance of BCa. MBD methylCap/seq was carried out to screen differentially methylated CpG islands using two BCa cell lines (5637 and T24), and two normal bladder tissue mix as control....

  16. Dickkopf 3 Promotes the Differentiation of Substantia Nigra Dopaminergic Neurons In Vivo and from Pluripotent Stem Cells In Vitro ArrayExpress

    ID: E-GEOD-58813

    Description: l mdDA precursor subset into SNc DA neurons. Dkk3 transcription in the murine VM coincides with the onset of mdDA neurogenesis and is required for the maintenance of LMX1A and consequently PITX3 expression in rostrolateral mdDA precursors, without affecting the proliferation or specification of their progenitors. Treatment of primary VM cells or differentiating pluripotent stem cells with recombinant WNT1 and/or DKK3 proteins consistently increases the proportion of mdDA cells with SNc DA neuron identity and promotes their survival in vitro. The SNc DA pro-differentiation and pro-survival properties of DKK3, together with its known anti-tumorigenic effect, therefore make it an ideal candidate for the improvement of regenerative and neuroprotective strategies in the treatment of PD. We performed gene expressio...

  17. Ascl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state OmicsDI

    ID: E-GEOD-27174

    Date Released: 03-27-2012

    Description: Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopi...

  18. Identification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population BioProject

    ID: PRJNA148095

    Keywords: Epigenomics

    Access Type: download

    dataset.description: , KCNV1, ECEL1, TMEM26, TAL1, PROX1, SLC6A20, and LMX1A) capable of differentiating BCa from normal control. Subsequent validation in a large sample size enabled the optimisation of 5 methylation targets (VAX1, KCNV1, TAL1, PPOX1 and CFTR) for BCa diagnosis with sensitivity and specificity of 86.32% and 87.13%, respectively. In addition, VAX1 and LMX1A methylation could predict the tumour recurrence. Conclusions: Tumor specific biomarkers of BCa could be established by first performing genome level methylation profiling with cell lines and then screening the potential targets in urine samples. The panel of methylated genes identified was promising for the early non-invasive detection and surveillance of BCa. Overall design: MBD methylCap/seq was carried out to screen differentially methylated CpG islands using two BCa cell lines (5637 and T24), and two normal bladder tissue mix as control....
  19. Ascl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state BioProject

    ID: PRJNA137375

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopi...
  20. Gene expression analysis of midbrain dopamine progenitors in embryonic mouse OmicsDI

    ID: E-GEOD-65094

    Date Released: 03-07-2015

    Description: es of FACS isolated GFP-negative cells from mouse Lmx1a-GFP ventral mesencephalon (definitively non-dopaminergic) were used as a reference population....


Displaying 20 of 33 results for "LMX1A"