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Displaying 20 of 689 results for "LAG3"
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  1. Lymphocyte Activation Gene-3 limits regulatory T cell proliferation and function in autoimmune diabetes BioProject

    ID: PRJNA371501

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. LAG3_RAT UniProt:Swiss-Prot

    ID: Q5BK54

    Description: Lymphocyte activation gene 3 protein Extracellular Helical Cytoplasmic Ig-...

  3. Expression data of human tonsilar CD4 positive T cell subsets BioProject

    ID: PRJNA298534

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Expression data of human tonsilar CD4 positive T cell subsets OmicsDI

    ID: E-GEOD-73927

    Date Released: 04-11-2016

    Description: igh amount of IL-10 and lack of FOXP3 expression. Lymphocyte-activation gene 3 (LAG3) is a CD4 homologue molecule and we have previously reported that LAG3 is expressed on IL-10 producing regulatory T cel...

  5. Expression data of human tonsilar CD4 positive T cell subsets ArrayExpress

    ID: E-GEOD-73927

    Description: igh amount of IL-10 and lack of FOXP3 expression. Lymphocyte-activation gene 3 (LAG3) is a CD4 homologue molecule and we have previously reported that LAG3 is expressed on IL-10 producing regulatory T cel...

  6. Transcription profiling of mouse CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells OmicsDI

    ID: E-MEXP-1343

    Date Released: 05-02-2014

    Description: Comparison of gene expression profile of CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3

  7. Transcription profiling of mouse CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells ArrayExpress

    ID: E-MEXP-1343

    Description: Comparison of gene expression profile of CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3

  8. Lymphocyte activation gene3 and coronary artery disease. BioProject

    ID: PRJNA348114

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells ArrayExpress

    ID: E-GEOD-53514

    Description: limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of ...

  10. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells BioProject

    ID: PRJNA232183

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. IL-27 stimulation in Foxp3+ Tregs improves suppressive function and therapeutic efficacy ArrayExpress

    ID: E-GEOD-63455

    Description: IL-27 stimulation of Tregs induced expression of LAG3, a surface molecule implicated in negatively regulating immune responses. LAG3 expression in IL-27-stimulated Tregs was critical to mediate suppressive Treg function. Finally, human Tregs also displayed enhanced suppressive function and LAG3 expression in response to IL-27 stimulation. Taken together, our results highlight a novel function of the IL-27/LAG3 axis in Treg regulation of inflammatory responses in the intestine. FACS purified Foxp3+ Tregs were stimulated in the presence of media or IL-27 to compare IL-27 induced gene profiles. Four samples (media stimulated or IL-27-stimulated) were collected from four independent experiments. Genes altered by IL-27 treatment were compared to those of media stimulated Tregs....

  12. Transcription profiling of human Chronic Lymphocytic Leukemia cells with mutated and unmutated IGHV ArrayExpress

    ID: E-TABM-696

    Description: High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Asso...

  13. IL-27 stimulation in Foxp3+ Tregs improves suppressive function and therapeutic efficacy BioProject

    ID: PRJNA267833

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. IL-27 stimulation in Foxp3+ Tregs improves suppressive function and therapeutic efficacy OmicsDI

    ID: E-GEOD-63455

    Date Released: 12-03-2015

    Description: IL-27 stimulation of Tregs induced expression of LAG3, a surface molecule implicated in negatively regulating immune responses. LAG3 expression in IL-27-stimulated Tregs was critical to mediate suppressive Treg function. Finally, human Tregs also displayed enhanced suppressive function and LAG3 expression in response to IL-27 stimulation. Taken together, our results highlight a novel function of the IL-27/LAG3 axis in Treg regulation of inflammatory responses in the intestine. FACS purified Foxp3+ Tregs were stimulated in the presence of media or IL-27 to compare IL-27 induced gene profiles. Four samples (media stimulated or IL-27-stimulated) were collected from four independent experiments. Genes altered by IL-27 treatment were compared to those of media stimulated Tregs....

  15. ammation promotes lung carcinogenesis through the activation of preneoplastic lesions in the context of an immunosuppressive microenvirontment... BioProject

    ID: PRJNA186440

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Egr2-dependent expression in T cell anergy ArrayExpress

    ID: E-GEOD-46242

    Description: We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for the induction of anergy in vitro and in vivo, which was identified based on its ability to regulate the expression of inhibitory signaling molecules diacylglycerol kinase (DGK)-a and -z. We reasoned that other transcriptional targets of Egr2 might encode additional factors i...

  17. FDC-E vs FDC-D BioProject

    ID: PRJNA91731

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. ammation promotes lung carcinogenesis through the activation of preneoplastic lesions in the context of an immunosuppressive microenvirontment... ArrayExpress

    ID: E-GEOD-43453

    Description: ncreased the expression of PDCD1, TGFβ-1, MCP-1, LAG3, and Foxp3 and the presence of regulatory T cells within preneoplastic lesions. In addition concomitant chronic inflammation changed the K-ras mutational profile of the generated tumors from Q61R to G12D transition. In summary, these data identify early molecular mechanisms underlying lung carcinogenesis in an inflammatory context at different steps, providing a novel approach for the identification of drivers from preneoplastic to neoplastic lesions Gene expression profile was analyzed in 11 individual lesions (8 adenomas and 3 adenocarcinomas) from the NDMA-silica treated mice and 5 lesions (2 adenomas, and 3 adenocarcinomas) from NDMA-only treated mice...

  19. Transcriptome analysis in chronic lymphocytic leukemia cells using RNA sequencing (RNA-seq) ArrayExpress

    ID: E-GEOD-66117

    Description: samples (n=34), in which both DNA methylation and gene expression data were available, demonstrated excellent correlation between DNA methylation and gene expression. Several genes whose expression status was previously shown to be associated with CLL prognosis such as ZAP70, CRY1, LDOC1, SEPT10, LAG3, and LPL were differentially methylated in the promoter regions between M-CLL and U-CLL samples indicating that DNA methylation plays an important role in defining the gene expression patterns of these prognostic genes. We further validated 9 genes with IGHV-specific DMRs in the promoter regions using bisulfite pyrosequencing, and the results demonstrated excellent correlation between differential methylation and IGHV mutation status. These novel differentially methylated genes could be developed into biomarkers for CLL prognosis. In addition, DNA hypomethylation was observed in a significant number of genes involved in lymphocyte activation such as PDCD1, NFAT1, and CD5. DNA hypomethylation was observed in the proximal promoter and far up-stream enhancer regions of CD5, an important cell surface marker that uniquely identifies CLL. Overall, the DNA methylation landscape in CLL patients indicates that CLL B cells possess an active B-cell phenotype; at the same time, U-CLL and M-CLL are faithfully committed to their lineage resembling either naïve or memory B-cells. In summary, this comprehensive DNA methylation analysis has identified a large number of novel epigenetic changes in CLL patients. The results from this study will further advance our understanding of the epigenetic contribution to molecular subtypes in CLL. To perform a transcriptome analysis in CLL, we generated sequencing libraries from total RNA isolated from purified B-cells of CLL patients and h...

  20. primary FDC BioProject

    ID: PRJNA94459

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 689 results for "LAG3"