KRT6A | bioCADDIE Data Discovery Index
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Displaying 13 of 13 results for "KRT6A"
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  1. K2C6A_RAT UniProt:Swiss-Prot

    ID: Q4FZU2

    Description: Keratin, type II cytoskeletal 6A Head Rod Coil 1A Linker 1 Coil 1B Linker 12 Coil 2 Tail Stutter

    gene.name: Krt6a
  2. Microarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow o... ArrayExpress

    ID: E-GEOD-59631

    Description: e expression of EPCAM, KRT8, KRT18, KRT19, KRT14, KRT6a, KRT5, KLK3 (PSA), MAGEA2, MAGEA4, PTPRC (CD45), CD33, CD34, CD19, GYPC, SCL4A1 (band 3), and HBA2. Using these transcripts we found it impossible to reliably identify true DCCs. We then applied combined genome and transcriptome analysis of single cells and found that EpCAM+ cells from controls expressed transcripts thought to be epithelial-specific, while true DCCs may express haematopoietic transcripts. These results point to an unexpected plasticity of epithelial cancer cells in bone marrow and question common transcriptional criteria to identify DCCs. Array-CGH was used to analyze EpCAM-positive single cells isolated from bone marrow of M0-stage prostate cancer patients, and individuals without cancer. The purpose was to demonstrate that cells with genomic aberrations are true tumour cells....

  3. Frizzled6 deficiency disrupts the differentiation process of nail development ArrayExpress

    ID: E-GEOD-40763

    Description: Krt81, Krt34 and Krt31; two epithelial keratins, Krt6a and Krt6b; and transglutaminase1 were known to be expressed in nails and involved in nail abnormality when dysregulated. Immunohistochemical studies revealed decreased expression of Krt86, Krt6b and involucrin in the epidermal portion of the claw field in the knockout embryos. We further show that Dkk4, a Wnt antagonist, was significantly down-regulated in Fzd6-/- mice along with Wnt, Bmp and Hh family genes; and Dkk4 transgenic mice showed a subtly but appreciably modified claw phenotype. Thus, Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation. Heterozygous Fzd6+/- mice (kindly provided by Dr. J. Nathans) were crossed to generate Fzd6+/-, Fzd6-/- and wild-type offspring. Timed matings were set up to harvest embryos at E14.5, E16.5 and E18.5. The morning after mating was designated as E0.5. Tails and the digital tips from forelimbs of three wild-type and Fzd6-/- mice from each embryonic time-point were excised, immediately frozen on dry ice, and stored at ...

  4. Gene expression profiling of mouse tumors arising from Keratin 6-positive mammary cells ArrayExpress

    ID: E-GEOD-20614

    Description: Conventional transgenic and knockout models do not allow selective introduction of oncogenic alterations into the progenitor population of mammary cel...

  5. Frizzled6 deficiency disrupts the differentiation process of nail development BioProject

    ID: PRJNA174857

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Krt81, Krt34 and Krt31; two epithelial keratins, Krt6a and Krt6b; and transglutaminase1 were known to be expressed in nails and involved in nail abnormality when dysregulated. Immunohistochemical studies revealed decreased expression of Krt86, Krt6b and involucrin in the epidermal portion of the claw field in the knockout embryos. We further show that Dkk4, a Wnt antagonist, was significantly down-regulated in Fzd6-/- mice along with Wnt, Bmp and Hh family genes; and Dkk4 transgenic mice showed a subtly but appreciably modified claw phenotype. Thus, Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation. Overall design: Heterozygous Fzd6+/- mice (kindly provided by Dr. J. Nathans) were crossed to generate Fzd6+/-, Fzd6-/- and wild-type offspring. Timed matings were set up to harvest embryos at E14.5, E16.5 and E18.5. The morning after mating was designated as E0.5. Tails and the digital tips from forelimbs of three wild-type and Fzd6-/- mice from each embryonic time-point were excised, immediately frozen on dry ice...
  6. Identifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions ArrayExpress

    ID: E-GEOD-41732

    Description: Digital dermatitis is a painful foot disease compromising welfare in dairy cattle. The disease has a complex multibacterial aetiology, but little is k...

  7. Microarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow o... BioProject

    ID: PRJNA255879

    Keywords: Variation

    Access Type: download

    dataset.description: e expression of EPCAM, KRT8, KRT18, KRT19, KRT14, KRT6a, KRT5, KLK3 (PSA), MAGEA2, MAGEA4, PTPRC (CD45), CD33, CD34, CD19, GYPC, SCL4A1 (band 3), and HBA2. Using these transcripts we found it impossible to reliably identify true DCCs. We then applied combined genome and transcriptome analysis of single cells and found that EpCAM+ cells from controls expressed transcripts thought to be epithelial-specific, while true DCCs may express haematopoietic transcripts. These results point to an unexpected plasticity of epithelial cancer cells in bone marrow and question common transcriptional criteria to identify DCCs. Overall design: Array-CGH was used to analyze EpCAM-positive single cells isolated from bone marrow of M0-stage prostate cancer patients, and individuals without cancer. The purpose was to demonstrate that cells with genomic aberrations are true tumour cells....
  8. Microarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow o... OmicsDI

    ID: E-GEOD-59631

    Date Released: 10-25-2014

    Description: e expression of EPCAM, KRT8, KRT18, KRT19, KRT14, KRT6a, KRT5, KLK3 (PSA), MAGEA2, MAGEA4, PTPRC (CD45), CD33, CD34, CD19, GYPC, SCL4A1 (band 3), and HBA2. Using these transcripts we found it impossible to reliably identify true DCCs. We then applied combined genome and transcriptome analysis of single cells and found that EpCAM+ cells from controls expressed transcripts thought to be epithelial-specific, while true DCCs may express haematopoietic transcripts. These results point to an unexpected plasticity of epithelial cancer cells in bone marrow and question common transcriptional criteria to identify DCCs. Array-CGH was used to analyze EpCAM-positive single cells isolated from bone marrow of M0-stage prostate cancer patients, and individuals without cancer. The purpose was to demonstrate that cells with genomic aberrations are true tumour cells....

  9. Frizzled6 deficiency disrupts the differentiation process of nail development OmicsDI

    ID: E-GEOD-40763

    Date Released: 06-02-2014

    Description: Krt81, Krt34 and Krt31; two epithelial keratins, Krt6a and Krt6b; and transglutaminase1 were known to be expressed in nails and involved in nail abnormality when dysregulated. Immunohistochemical studies revealed decreased expression of Krt86, Krt6b and involucrin in the epidermal portion of the claw field in the knockout embryos. We further show that Dkk4, a Wnt antagonist, was significantly down-regulated in Fzd6-/- mice along with Wnt, Bmp and Hh family genes; and Dkk4 transgenic mice showed a subtly but appreciably modified claw phenotype. Thus, Fzd6-mediated Wnt signaling likely regulates the overall differentiation process of nail/claw formation. Heterozygous Fzd6+/- mice (kindly provided by Dr. J. Nathans) were crossed to generate Fzd6+/-, Fzd6-/- and wild-type offspring. Timed matings were set up to harvest embryos at E14.5, E16.5 and E18.5. The morning after mating was designated as E0.5. Tails and the digital tips from forelimbs of three wild-type and Fzd6-/- mice from each embryonic time-point were excised, immediately frozen on dry ice, and stored at ...

  10. Identifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions BioProject

    ID: PRJNA178260

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Gene expression profiling of mouse tumors arising from Keratin 6-positive mammary cells BioProject

    ID: PRJNA124795

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Genomics of oral cancer cells ArrayExpress

    ID: E-GEOD-15308

    Description: Dynamic changes in RNA and protein levels after exposure to 100µmol/L nimesulide and low-dose 0.5µmol/L cisplatin in oral cancer cells were screened...

  13. Genomics of oral cancer cells BioProject

    ID: PRJNA115837

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 13 of 13 results for "KRT6A"