KMT5B | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 66 results for "KMT5B"
i
  1. Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex With S-Adenosyl-L-Methionine PDB

    ID: PDB:3S8P

    Description: Histone-lysine N-methyltransferase SUV420H1 (E.C.2.1.1.43)

  2. The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity PDB

    ID: PDB:5CPR

    Description: Histone-lysine N-methyltransferase SUV420H1 (E.C.2.1.1.43)

  3. KMT5B_BOVIN UniProt:Swiss-Prot

    ID: Q29RP8

    Description: Histone-lysine N-methyltransferase KMT5B SET

  4. KT5BB_XENLA UniProt:Swiss-Prot

    ID: Q5RJX8

    Description: Histone-lysine N-methyltransferase KMT5B-B SET

  5. KT5BA_XENLA UniProt:Swiss-Prot

    ID: Q6GP17

    Description: Histone-lysine N-methyltransferase KMT5B-A SET

  6. PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G+C-rich regions of the mouse genome ArrayExpress

    ID: E-GEOD-37604

    Description: ylation. Conversely, depletion of ESET (KMT1E) or SUV420H1/H2 (KMT5B/C) affected H3K9me3 and H4K20me3, respectively, without altering H4R3me2s at ICRs. Combined, our data indicate that PRMT5-mediated H4R3me2s uniquely marks the mammalian genome, mostly at G + C-rich regions, and independently from transcriptional activity or chromatin repression. Furthermore, comparative bioinformatics analyses suggest a putative role of PRMT5-mediated H4R3me2s in chromatin configuration in the nucleus. High throughput sequencing data from H4R3me2s native ChIP samples from mouse embryonic stem cells and fibroblasts were generated using Illumina Hi-seq 2000....

  7. Expression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts) BioProject

    ID: PRJNA246227

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G+C-rich regions of the mouse genome. BioProject

    ID: PRJNA162317

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ylation. Conversely, depletion of ESET (KMT1E) or SUV420H1/H2 (KMT5B/C) affected H3K9me3 and H4K20me3, respectively, without altering H4R3me2s at ICRs. Combined, our data indicate that PRMT5-mediated H4R3me2s uniquely marks the mammalian genome, mostly at G + C-rich regions, and independently from transcriptional activity or chromatin repression. Furthermore, comparative bioinformatics analyses suggest a putative role of PRMT5-mediated H4R3me2s in chromatin configuration in the nucleus. Overall design: High throughput sequencing data from H4R3me2s native ChIP samples from mouse embryonic stem cells and fibroblasts were generated using Illumina Hi-seq 2000....
  9. Expression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts) ArrayExpress

    ID: E-GEOD-57310

    Description: mpare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were transduced with lentivirus to express indicated PREX2 mutants.

  10. Expression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts) OmicsDI

    ID: E-GEOD-57310

    Date Released: 04-09-2016

    Description: mpare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were transduced with lentivirus to express indicated PREX2 mutants.

  11. PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G+C-rich regions of the mouse genome. OmicsDI

    ID: E-GEOD-37604

    Date Released: 11-25-2013

    Description: ylation. Conversely, depletion of ESET (KMT1E) or SUV420H1/H2 (KMT5B/C) affected H3K9me3 and H4K20me3, respectively, without altering H4R3me2s at ICRs. Combined, our data indicate that PRMT5-mediated H4R3me2s uniquely marks the mammalian genome, mostly at G + C-rich regions, and independently from transcriptional activity or chromatin repression. Furthermore, comparative bioinformatics analyses suggest a putative role of PRMT5-mediated H4R3me2s in chromatin configuration in the nucleus. High throughput sequencing data from H4R3me2s native ChIP samples from mouse embryonic stem cells and fibroblasts were generated using Illumina Hi-seq 2000....

  12. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases PDB

    ID: PDB:4BUP

    Description: HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1 (E.C.2.1.1.43)

  13. Histone chaperone CAF-1 is essential for retrotransposon silencing by mediating histone H4K20me3 deposition in mouse preimplantation embryos ArrayExpress

    ID: E-GEOD-69260

    Description: omethylated. Here we show a histone chaperon, CAF-1, is responsible for retrotransposon silencing at the morula-blastocyst stages by depositing histone H4 lysine 20 trimethylation (H4K20me3). Knockdown of CAF-1 with a specific siRNA resulted in derepression of LINE-1, SINE-B2 and IAP associated with the decreased H4K20me3 level, and arrested embryonic development at the morula stage. The identical result...

  14. KMT5B_RAT UniProt:Swiss-Prot

    ID: P0C2N5

    Description: Histone-lysine N-methyltransferase KMT5B SET Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

  15. Histone chaperone CAF-1 is essential for retrotransposon silencing by mediating histone H4K20me3 deposition in mouse preimplantation embryos BioProject

    ID: PRJNA285041

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing ArrayExpress

    ID: E-GEOD-26826

    Description: ces allowed accurate and quantitative analysis of 1 million CpGs in more than 21,408 CGIs and 15,946 transcriptional regulatory regions. More than 85% of capture probes successfully yielded quantitative DNA methylation information of targeted regions. In this study, we generated genome-wide, single-base resolution DNA methylation maps in three of the most commonly used breast ...

  17. Gene-expression profiles after siRNA knockdown and overexpression of bromodomian containing 1 (BRD1) in HEK293T cells ArrayExpress

    ID: E-GEOD-79255

    Description: Background: The bromodomain containing 1 (BRD1) gene has been implicated with transcriptional regulation, brain development and susceptibility to schizophrenia and bipola...

  18. Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing OmicsDI

    ID: E-GEOD-26826

    Date Released: 08-22-2013

    Description: ces allowed accurate and quantitative analysis of 1 million CpGs in more than 21,408 CGIs and 15,946 transcriptional regulatory regions. More than 85% of capture probes successfully yielded quantitative DNA methylation information of targeted regions. In this study, we generated genome-wide, single-base resolution DNA methylation maps in three of the most commonly used breast ...

  19. Crystal structure of suppressor of variegation 4-20 homolog 2 PDB

    ID: PDB:3RQ4

    Description: Histone-lysine N-methyltransferase SUV420H2 (E.C.2.1.1.43)

  20. Histone chaperone CAF-1 is essential for retrotransposon silencing by mediating histone H4K20me3 deposition in mouse preimplantation embryos OmicsDI

    ID: E-GEOD-69260

    Date Released: 12-02-2015

    Description: omethylated. Here we show a histone chaperon, CAF-1, is responsible for retrotransposon silencing at the morula-blastocyst stages by depositing histone H4 lysine 20 trimethylation (H4K20me3). Knockdown of CAF-1 with a specific siRNA resulted in derepression of LINE-1, SINE-B2 and IAP associated with the decreased H4K20me3 level, and arrested embryonic development at the morula stage. The identical result...


Displaying 20 of 66 results for "KMT5B"