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Displaying 20 of 30 results for "KLF12"
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  1. KLF12 overexpression effect in colorectal cancer cells BioProject

    ID: PRJNA312448

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational researc... ArrayExpress

    ID: E-GEOD-53127

    Description: antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most am...

  3. Study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational researc... BioProject

    ID: PRJNA230923

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most am...
  4. Study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational researc... OmicsDI

    ID: E-GEOD-53127

    Date Released: 06-03-2014

    Description: antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most am...

  5. PRIDE PXD001976 - p53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses OmicsDI

    ID: MSV000079767

    Date Released:

    Description: proliferation in SW480 cells. Furthermore, HMGB1, KLF12 and CIT mRNAs were confirmed as direct targets of the p53-induced miR-34a, miR-205 and miR-486-5p, respectively. In line with the loss of p53 function during tumor progression, elevated expression of HMGB1, KLF12 and CIT was detected in advanced stages of cancer. This study provides new insights and a comprehensive catalogue of p53-mediated regulations and p53 DNA binding in CRC cells....

  6. p53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses OmicsDI

    ID: PXD001976

    Date Released: 07-23-2015

    Description: proliferation in SW480 cells. Furthermore, HMGB1, KLF12 and CIT mRNAs were confirmed as direct targets of the p53-induced miR-34a, miR-205 and miR-486-5p, respectively. In line with the loss of p53 function during tumor progression, elevated expression of HMGB1, KLF12 and CIT was detected in advanced stages of cancer. This study provides new insights and a comprehensive catalogue of p53-mediated regulations and p53 DNA binding in CRC cells....

  7. Gene expression profiling of intracranial aneurysms BioProject

    ID: PRJNA234765

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ss of aneurysm walls. The expressions of Krüppel-like family of transcription factors (KLF2, KLF12, and KLF15), which were anti-inflammatory regulators, and CDKN2A, which was located on chromosome 9p21 that was the most consistently replicated locus in genome-wide association studies of IA, were also down-regulated. We demonstrate that gene expression patterns of RIAs were different according to age of the patients. The results suggest that macrophage-mediated inflammation is a key biological pathway for IA rupture. The identified genes can be good candidates for molecular markers of rupture-prone IAs and therapeutic targets. Overall design: We determined gene expression levels of 8 ruptured intracranial aneurysms (RIAs) (5 early and 3 late RIAs), 5 unruptured intracranial aneurysms (UIAs), and 10 superficial temporal arteries (STAs)....
  8. Gene expression profiles of human immature dendritic cells co-cultivated with Aspergillus fumigatus, Candida albicans and LPS ArrayExpress

    ID: E-GEOD-69723

    Description: our independent donors were harvested after 6 and 12 hours co-culture with A. fumigatus, C. albicans and LPS and analyzed with Affymetrix whole genome expression arrays. In general, transcriptomic analysis revealed a clustering of the A. fumigatus and C. albicans stimulated DCs. However, LPS and fungi-dependent gene expression showed more common similarities compared...

  9. Global miRNA expression profiling of Junb-deficient murine embryonic fibroblasts BioProject

    ID: PRJNA185769

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The AP-1 transcription factor subunit Junb acts as a context-dependent transcriptional
  10. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2 BioProject

    ID: PRJNA95775

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium BioProject

    ID: PRJNA121787

    Keywords: Other

    Access Type: download

    dataset.description: The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) conf...
  12. STRUCTURAL COMPARISON BETWEEN THE D(CTAG) SEQUENCE IN OLIGONUCLEOTIDES AND TRP AND MET REPRESSOR-OPERATOR COMPLEXES PDB

    ID: PDB:249D

    Description: 5'-D(*CP*GP*CP*TP*CP*TP*AP*GP*AP*GP*CP*G)-3'

  13. Gene expression profiles of human immature dendritic cells co-cultivated with Aspergillus fumigatus, Candida albicans and LPS OmicsDI

    ID: E-GEOD-69723

    Date Released: 06-27-2015

    Description: our independent donors were harvested after 6 and 12 hours co-culture with A. fumigatus, C. albicans and LPS and analyzed with Affymetrix whole genome expression arrays. In general, transcriptomic analysis revealed a clustering of the A. fumigatus and C. albicans stimulated DCs. However, LPS and fungi-dependent gene expression showed more common similarities compared...

  14. Transcription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on ... OmicsDI

    ID: E-GEOD-4883

    Date Released: 10-02-2015

    Description: , RANTES, several other CC and CXC chemokines, IL-2 receptor-β, and leukemia inhibitory factor), members of the tumor necrosis factor family (e.g. lymphotoxin beta and TRAIL), VCAM-1, ICAM-3, and tissue factor (TF). Simvastatin also modulated the expression of several transcription factors essential for the inflammatory response: simvastatin downregulated the expression of NF-kappaB relA/p65 subunit and ets-1 transcription factor, and upregulated the expression of a novel atheroprotective transcription factor, Kruppel-like factor

  15. Bach2 inhibits Th2-type immune responses by regulating glutamine metabolism [ChIP-seq] BioProject

    ID: PRJNA267601

    Keywords: Epigenomics

    Access Type: download

    dataset.description: l role of glutamine metabolism in regulating type 2-immune response. Bach2, a transcriptional repressor, binds to an AP-1 motif, and suppresses Th2 cell differentiation and glutaminolysis. Glutaminase 2, which controls glutamine metabolism, was identified as a Bach2 target gene. The pharmacological inhibition of glutamine metabolism normalized allergic lung inflamma...
  16. Bach2 inhibits Th2-type immune responses by regulating glutamine metabolism [expression array] BioProject

    ID: PRJNA272912

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: l role of glutamine metabolism in regulating type 2-immune response. Bach2, a transcriptional repressor, binds to an AP-1 motif, and suppresses Th2 cell differentiation and glutaminolysis. Glutaminase 2, which controls glutamine metabolism, was identified as a Bach2 target gene. The pharmacological inhibition of glutamine metabolism normalized allergic lung inflamma...
  17. 5'-D(*GP*CP*AP*GP*AP*CP*GP*TP*CP*TP*GP*C)-3' Methionine Repressor binding site PDB

    ID: PDB:2B1D

    Description: 5'-D(*GP*CP*AP*GP*AP*CP*GP*TP*CP*TP*GP*C)-3'

  18. Transcription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on ... ArrayExpress

    ID: E-GEOD-4883

    Description: , RANTES, several other CC and CXC chemokines, IL-2 receptor-β, and leukemia inhibitory factor), members of the tumor necrosis factor family (e.g. lymphotoxin beta and TRAIL), VCAM-1, ICAM-3, and tissue factor (TF). Simvastatin also modulated the expression of several transcription factors essential for the inflammatory response: simvastatin downregulated the expression of NF-kappaB relA/p65 subunit and ets-1 transcription factor, and upregulated the expression of a novel atheroprotective transcription factor, Kruppel-like factor

  19. STRUCTURAL COMPARISON BETWEEN THE D(CTAG) SEQUENCE IN OLIGONUCLEOTIDES AND TRP AND MET REPRESSOR-OPERATOR COMPLEXES PDB

    ID: PDB:250D

    Description: 5'-D(*CP*GP*CP*TP*AP*GP*CP*G)-3'

  20. miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (microRNA) ArrayExpress

    ID: E-GEOD-54492

    Description: elanoma cells. miR-638 promoter analysis revealed transcription factor associated protein 2-α (TFAP2A) as a direct negative regulator of miR-638. Further analyses provided strong evidence for a double negative regulatory feedback loop between miR-638 and TFAP2A. Taken together, miR-638 may support melanoma progression by suppressing p53-mediated apoptosis pathways and by targeting the transcriptional repressor TFAP2A. TaqMan® low-density arrays (TLDA; human microRNA Cards A v2.1 & B v2.0, Applied Biosystems, Darmstadt, Germany) were used for measuring the expression of 667 human miRNAs in primary melanomas (PM, n=8), lymph node metastases (LNM, n=9) or distant cutaneous met...


Displaying 20 of 30 results for "KLF12"