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Displaying 20 of 24 results for "KLF11"
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  1. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ super-enhancers BioProject

    ID: PRJNA255992

    Keywords: Other

    Access Type: download

  2. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ super-enhancers ArrayExpress

    ID: E-GEOD-59703

    Description: brite adipocyte-selective genes. We identify the KLF11 gene based on its association with a PPARγ super-enhancer and show that KLF11 is a novel browning factor directly induced by rosiglitazone and required for the activation of brite adipocyte-selective gene program by rosiglitazone. Genome-wide profiling of Dnase I hypersenstive (DHS) sites, epigenomic marks, transcription factor and co-factor binding, and gene expression in hMADS white and brite adipocytes...

  3. Expression data from Panc1 pancreatic epithelial cells OmicsDI

    ID: E-GEOD-56778

    Date Released: 08-09-2014

    Description: Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information ...

  4. Expression data from Panc1 pancreatic epithelial cells ArrayExpress

    ID: E-GEOD-56778

    Description: Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information ...

  5. Expression data from Panc1 pancreatic epithelial cells BioProject

    ID: PRJNA244565

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Krüppel-like factors (KLFs) are a group of master regulators of gene expression conserved from flies to human. However, scant information ...
  6. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ super-enhancers OmicsDI

    ID: E-GEOD-59703

    Date Released: 01-02-2015

    Description: brite adipocyte-selective genes. We identify the KLF11 gene based on its association with a PPARγ super-enhancer and show that KLF11 is a novel browning factor directly induced by rosiglitazone and required for the activation of brite adipocyte-selective gene program by rosiglitazone. Genome-wide profiling of Dnase I hypersenstive (DHS) sites, epigenomic marks, transcription factor and co-factor binding, and gene expression in hMADS white and brite adipocytes...

  7. Relationship between Genome-Wide DNA Methylation and Gene Expression in Uterine Leiomyoma ArrayExpress

    ID: E-GEOD-31699

    Description: e selected two genes, the known tumor suppressors KLF11 and DLEC1, and verified promoter hypermethylation and mRNA repression using bisulfite sequencing and real-time PCR. Incubation of primary leiomyoma smooth muscle cells with a DNA methyltransferase inhibitor restored KLF11 and DLEC1 mRNA levels. paired LM and MM tissue samples...

  8. RNA-seq identified KLF16 as a negative regulator of adipogenesis BioProject

    ID: PRJNA296514

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (D7) of primary brown preadipocyte and found that Kruppel-like factor 16 (KLF11) gene that was downregulated in D7 was a novel negative regulator of adipogenesis. Overall design: To explore global view of gene expressi...
  9. Relationship between Genome-Wide DNA Methylation and Gene Expression in Uterine Leiomyoma BioProject

    ID: PRJNA145625

    Keywords: Other

    Access Type: download

    dataset.description: e selected two genes, the known tumor suppressors KLF11 and DLEC1, and verified promoter hypermethylation and mRNA repression using bisulfite sequencing and real-time PCR. Incubation of primary leiomyoma smooth muscle cells with a DNA methyltransferase inhibitor restored KLF11 and DLEC1 mRNA levels. Overall design: paired LM and MM tissue samples...
  10. Relationship between Genome-Wide DNA Methylation and Gene Expression in Uterine Leiomyoma OmicsDI

    ID: E-GEOD-31699

    Date Released: 05-11-2012

    Description: e selected two genes, the known tumor suppressors KLF11 and DLEC1, and verified promoter hypermethylation and mRNA repression using bisulfite sequencing and real-time PCR. Incubation of primary leiomyoma smooth muscle cells with a DNA methyltransferase inhibitor restored KLF11 and DLEC1 mRNA levels. paired LM and MM tissue samples...

  11. KLF13 regulate memory-like CD8 T cells BioProject

    ID: PRJNA134641

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Transcription profiling of human and moise primary hepatocytes from 12 donors were treated with PPARI? agonist Wy14643 ArrayExpress

    ID: E-GEOD-17254

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARα activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARα as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARα regulates a mostly divergent set of genes in mouse and human hepatocytes. GSE17250: Comparative analysis of gene regulation by the transcription factor PPARα_mouse; GSE17251: Comparative analysis of gene regulation by the transcription factor PPARα_human Experiment Overall Design: Refer to individual Series...

  13. Klf4 gene disruption is linked to enhanced cellular proliferation and tumor formation BioProject

    ID: PRJNA127289

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Kruppel-like factor 4 (KLF4) is involved in diverse biological processes such as cell cycle c...
  14. Transcription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse ArrayExpress

    ID: E-GEOD-17250

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARα activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARα as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARα regulates a mostly divergent set of genes in mouse and human hepatocytes. Experiment Overall Design: Primary hepatocytes from 6 mice from 6 different strains were treated with the PPARα agonist Wy14643 for 6 and 24 hours, and gene expression profiling was performed using Affymetrix GeneChips. Mouse primary hepatocytes were isolated by two-step collagenase perfusion from 6 different strains of mouse; NMRI, SV129, FVB, DBA, BALB/C and C57BL/6J. Cells were plated on collagen-coated six-well plates. Viability was determined by Trypan Blue exclusion, and was at least 75%. Hepatocytes were suspended in William's E medium (Lonza Bioscience, Verviers, Belgium) supplemented with 10% (v/v) fetal calf serum, 20 m-units/mL insulin, 10 nM dexamethasone, 100 U/mL penicillin, 100 μg/mL of streptomycin, 0.25 μg/mL fungizone and 50 μg/mL gentamycin. After four hours the medium was discarded and replaced with fresh medium. The next day, cells were incubated in fresh medium in the presence or absence of Wy14643 (10 microM) dissolved in DMSO for 6 and 24 hours, followed by RNA isolation. A 5-fold lower concentration of Wy14643 was used in mouse primary hepatocytes to take into account the higher affinity of Wy14643 for mouse PPARα compared to human PPARα....

  15. Transcription profiling by array of human primary hepatocytes after treatment with pirinixic acid ArrayExpress

    ID: E-GEOD-17251

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARalpha activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARalpha as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARalpha regulates a mostly divergent set of genes in mouse and human hepatocytes. Experiment Overall Design: Primary hepatocytes from 6 human subjects were treated with the PPARalpha agonist Wy14643 for 6 and 24 hours, and gene expression profiling was performed using Affymetrix GeneChips. Human hepatocytes and Hepatocyte Culture Medium Bulletkit were purchased from Lonza Bioscience (Verviers, Belgium). Primary hepatocytes were isolated from surgical liver biopsies obtained from six individual donors who underwent surgery after informed consent was obtained for surgery with subsequent use of samples in experiments. Hepatocytes were isolated with two-step collagenase perfusion method and the viability of the cells was over 80%. Cells were plated on collagen-coated six-well plates and filled with maintenance medium. Upon arrival of the cells, the medium was discarded and was replaced by Hepatocyte Culture Medium (HCM) with additives. The additives included Gentamicin sulphate/Amphotercin-B, Bovine serum albumin (Fatty acid free), Transferrin, Ascorbic acid, Insulin, Epidermal growth factor, Hydrocortisone hemisuccinate. The next day, cells were incubated in fresh medium in the presence or absence of Wy14643 (50 microM) dissolved in DMSO for 6 and 24 hours, followed by RNA isolation....

  16. Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human BioProject

    ID: PRJNA118935

    Access Type: download

  17. Transcription profiling of human and moise primary hepatocytes from 12 donors were treated with PPARI? agonist Wy14643 OmicsDI

    ID: E-GEOD-17254

    Date Released: 03-27-2012

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARα activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARα as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARα regulates a mostly divergent set of genes in mouse and human hepatocytes. GSE17250: Comparative analysis of gene regulation by the transcription factor PPARα_mouse; GSE17251: Comparative analysis of gene regulation by the transcription factor PPARα_human Experiment Overall Design: Refer to individual Series...

  18. Comparative analysis of gene regulation by the transcription factor PPAR? between mouse and human - Homo sapiens GEMMA

    ID: 1517

    Keywords: functional genomics

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARalpha activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARalpha as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARalpha regulates a mostly divergent set of genes in mouse and human hepatocytes. GSE17254.2: Comparative analysis of gene regulation by the transcription factor PPARalpha_mouse GSE17254.1: Comparative analysis of gene regulation by the transcription factor PPARalpha_human Last Updated (by provider): Jan 15 2010 Contributers: Maryam Rakhshandehroo Michael Müller Sander Kersten Guido Hooiveld...

  19. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human - Mus musculus GEMMA

    ID: 1516

    Keywords: functional genomics

    Description: ulated in both species, including CREB3L3, KLF10, KLF11 and MAP3K8. Our results suggest that PPARalpha activation has a major impact on gene regulation in human hepatocytes. Importantly, the role of PPARalpha as master regulator of hepatic lipid metabolism is generally well-conserved between mouse and human. Overall, however, PPARalpha regulates a mostly divergent set of genes in mouse and human hepatocytes. GSE17254.2: Comparative analysis of gene regulation by the transcription factor PPARalpha_mouse GSE17254.1: Comparative analysis of gene regulation by the transcription factor PPARalpha_human Last Updated (by provider): Jan 15 2010 Contributers: Maryam Rakhshandehroo Michael Müller Sander Kersten Guido Hooiveld...

  20. Comparative analysis of gene regulation by the transcription factor PPARα_human BioProject

    ID: PRJNA123587

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 24 results for "KLF11"