Gene expression changes following knockdown of Kdm2b on mESCs BioProject

ID: PRJNA174681

Keywords: Transcriptome or Gene expression

Access Type: download

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [Expression profiling] ArrayExpress

ID: E-GEOD-41298

Description: known. Here, we show that the histone demethylase Kdm2b is highly expressed in mESCs and regulated by the pluripotent factors Oct4/Sox2 directly. Depletion of Kdm2b in mESCs causes de-repression of lineage-specific genes and induces early differentiation. The function of Kdm2b depends on its CXXC-ZF domain, which mediates Kdm2b’s genome-wide binding to CpG islands (CGIs). Kdm2b in...

Zinc fingers of KDM2B PDB

ID: PDB:4O64

Description: Lysine-specific demethylase 2B

Deletion of KDM2B DNA-binding domain affects RING1B and SUZ12 occupancy BioProject

ID: PRJNA229497

Keywords: Other

Access Type: download

KDM2B binds CpG islands and modulates recruitment of Ring1b BioProject

ID: PRJNA175125

Keywords: Epigenomics

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Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [Kras background mouse gene expression] BioProject

ID: PRJNA302012

Keywords: Transcriptome or Gene expression

Access Type: download

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [ChIP-Seq] BioProject

ID: PRJNA176504

Keywords: Epigenomics

Access Type: download

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq] BioProject

ID: PRJNA289452

Keywords: Transcriptome or Gene expression

Access Type: download

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq] BioProject

ID: PRJNA289206

Keywords: Epigenomics

Access Type: download

KDM2B binds CpG islands and modulates recruitment of Ring1b ArrayExpress

ID: E-GEOD-40860

Description: plexes remains unknown. Here we discover that the KDM2B protein, by virtue of its ZF-CxxC DNA binding domain, specifically recognizes non-methylated DNA in CpG islands elements genome-wide. Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. These observations demonstrate an...

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq] OmicsDI

ID: E-GEOD-70624

Date Released: 02-27-2016

Description: d in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence. I...

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [Expression profiling] BioProject

ID: PRJNA176502

Keywords: Transcriptome or Gene expression

Access Type: download

Silencing of KDM2B leads to deregulation of apoptosis related genes in GBM BioProject

ID: PRJNA320464

Keywords: Transcriptome or Gene expression

Access Type: download

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes BioProject

ID: PRJNA176497

Access Type: download

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [Kras background mouse gene expression] ArrayExpress

ID: E-GEOD-74960

Description: d in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence. C...

Gene expression changes following knockdown of Kdm2b on mESCs ArrayExpress

ID: E-GEOD-40701

Description: In order to study the effects of Kdm2b binding at CpG islands, Kdm2b was knocked down in mouse embryonic stem cells using shRNA and gene expressi...

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [ChIP-Seq] ArrayExpress

ID: E-GEOD-41314

Description: known. Here, we show that the histone demethylase Kdm2b is highly expressed in mESCs and regulated by the pluripotent factors Oct4/Sox2 directly. Depletion of Kdm2b in mESCs causes de-repression of lineage-specific genes and induces early differentiation. The function of Kdm2b depends on its CXXC-ZF domain, which mediates Kdm2b’s genome-wide binding to CpG islands (CGIs). Kdm2b in...

Gene expression changes following knockdown of Kdm2b on mESCs OmicsDI

ID: E-GEOD-40701

Date Released: 01-14-2013

Description: In order to study the effects of Kdm2b binding at CpG islands, Kdm2b was knocked down in mouse embryonic stem cells using shRNA and gene expressi...

Deletion of KDM2B DNA-binding domain affects RING1B and SUZ12 occupancy ArrayExpress

ID: E-GEOD-52619

Description: The histone lysine demethylase protein, KDM2B, associates with the PCGF1/PRC1 complex and binds to non-methylated DNA through its ZF-CxxC domain, providing a possible mole...

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression] BioProject

ID: PRJNA302011

Keywords: Transcriptome or Gene expression

Access Type: download