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Displaying 20 of 28 results for "KDM2A"
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  1. Crystal structure of histone demethylase KDM2A-H3K36ME1 with NOG PDB

    ID: PDB:4QXH

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  2. Crystal structure of histone demethylase KDM2A-H3K36ME2 with NOG PDB

    ID: PDB:4QXC

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  3. Crystal structure of histone demethylase kdm2a-h3k36me2 with alpha-kg PDB

    ID: PDB:4QX7

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  4. crystal structure of histone demethylase KDM2A-H3K36ME3 with NOG PDB

    ID: PDB:4QXB

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  5. Crystal structure of mouse KDM2A-H3K36ME-NO complex PDB

    ID: PDB:4TN7

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Peptide

  6. Histone demethylase KDM2A-H3K36ME1-alpha-KG complex structure PDB

    ID: PDB:4QWN

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  7. Crystal structure of histone demethylase kdm2a-h3k36me3 complex with alpha-kg PDB

    ID: PDB:4QX8

    Description: Lysine-specific demethylase 2A (E.C.1.14.11.27), Histone

  8. CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] BioProject

    ID: PRJNA129455

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Chip-chip from THP1 cells with H3K4me3, H3K9me2 , H3K27me3, JARIDIA, LSD1, JHDM1A, JHDM2A, JHDM3A, SIN3A, SNF2H, BRG1 BioProject

    ID: PRJNA187980

    Keywords: Epigenomics

    Access Type: download

  10. Chip-chip from THP1 cells with H3K4me3, H3K9me2 , H3K27me3, JARIDIA, LSD1, JHDM1A, JHDM2A, JHDM3A, SIN3A, SNF2H, BRG1 ArrayExpress

    ID: E-GEOD-43869

    Description: THP1 cells were ChIPed with indicated antibodies. Comparison of selected chromatin marks in THP1 cells

  11. Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11) PDB

    ID: PDB:4BBQ

    Description: LYSINE-SPECIFIC DEMETHYLASE 2A (E.C.1.14.11.27)

  12. CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] ArrayExpress

    ID: E-GEOD-21201

    Description: show that CpG islands directly recruit the H3K36 specific lysine demethylase enzyme KDM2A. Genome wide analyses by ChIP-seq demonstrated a striking global association of KDM2A with CpG islands. Nucleation of KDM2A at these elements resulted in removal of H3K36 methylation creating CpG island chromatin that is uniquely depleted of this modification. KDM2A utilizes a zinc finger CxxC (ZF-CxxC) domain that specifically recognizes non-methylated CpG DNA and binding is blocked when the CpG DNA is methylated, thus constraining KDM2A to nonmethylated CpG islands. These data expose a remarkably straightforward mechanism through which

  13. CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] OmicsDI

    ID: E-GEOD-21201

    Date Released: 05-02-2014

    Description: show that CpG islands directly recruit the H3K36 specific lysine demethylase enzyme KDM2A. Genome wide analyses by ChIP-seq demonstrated a striking global association of KDM2A with CpG islands. Nucleation of KDM2A at these elements resulted in removal of H3K36 methylation creating CpG island chromatin that is uniquely depleted of this modification. KDM2A utilizes a zinc finger CxxC (ZF-CxxC) domain that specifically recognizes non-methylated CpG DNA and binding is blocked when the CpG DNA is methylated, thus constraining KDM2A to nonmethylated CpG islands. These data expose a remarkably straightforward mechanism through which

  14. CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] ArrayExpress

    ID: E-GEOD-18588

    Description: y defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory el...

  15. CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] OmicsDI

    ID: E-GEOD-18588

    Date Released: 04-03-2013

    Description: y defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory el...

  16. KDM2B binds CpG islands and modulates recruitment of Ring1b ArrayExpress

    ID: E-GEOD-40860

    Description: remains unknown. Here we discover that the KDM2B protein, by virtue of its ZF-CxxC DNA binding domain, specifically recognizes non-methylated DNA in CpG islands elements genome-wide. Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. These observations demonstrate an unexpected and direct link bet...

  17. CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] BioProject

    ID: PRJNA129049

    Keywords: Epigenomics

    Access Type: download

  18. KDM2B binds CpG islands and modulates recruitment of Ring1b BioProject

    ID: PRJNA175125

    Keywords: Epigenomics

    Access Type: download

    dataset.description: remains unknown. Here we discover that the KDM2B protein, by virtue of its ZF-CxxC DNA binding domain, specifically recognizes non-methylated DNA in CpG islands elements genome-wide. Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. These observations demonstrate an unexpected and direct link bet...
  19. ASH1L links histone H3 lysine 36 di-methylation to leukemia ArrayExpress

    ID: E-GEOD-73528

    Description: The histone methyltransferases MLL and ASH1L are trithorax-group proteins that interact genetically through undefined molecular mechani...

  20. KDM2B binds CpG islands and modulates recruitment of Ring1b OmicsDI

    ID: E-GEOD-40860

    Date Released: 01-14-2013

    Description: remains unknown. Here we discover that the KDM2B protein, by virtue of its ZF-CxxC DNA binding domain, specifically recognizes non-methylated DNA in CpG islands elements genome-wide. Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. These observations demonstrate an unexpected and direct link bet...


Displaying 20 of 28 results for "KDM2A"