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Displaying 20 of 50 results for "KCNJ4"
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  1. crystal structure of TIP-1 in complex with c-terminal of Kir2.3 PDB

    ID: PDB:3GJ9

    Description: Tax1-binding protein 3, C-terminal peptide from Inward rectifier potassium channel 4

  2. Adipose tissue transcriptome in insulin resistance BioProject

    ID: PRJNA136461

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g and after 3h hyperinsulinemia FIR x 5, FIS x 5, HIR x 5, HIS x 5 F=fasting, H=hyperinsulinemia, IR=Insulin-resistant, IS=Insulin-sensitive (FIR, FIS, HIR, HIS)...
  3. Adipose tissue transcriptome in insulin resistance ArrayExpress

    ID: E-GEOD-26637

    Description: g and after 3h hyperinsulinemia FIR x 5, FIS x 5, HIR x 5, HIS x 5 F=fasting, H=hyperinsulinemia, IR=Insulin-resistant, IS=Insulin-sensitive (FIR, FIS, HIR, HIS)...

  4. Interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression BioProject

    ID: PRJNA117375

    Keywords: Epigenomics

    Access Type: download

    dataset.description: a pathway with two other chaperones, Asf1 and the HIR complex, to create a repressive chromatin structure at core histone promoters. We found that activation of histone (HTA1) gene expression involves both relief of Rtt106-mediated repression by the activity of the histone acetyltransferase Rtt109 and restriction of Rtt106 to the promoter region by the bromodomain-containing protein Yta7. We propose that the maintenance of Asf1/HIR/Rtt106-mediated repressive chromatin domains is the primary mechanism of cell cycle regulation of histone promoters. Our data suggest that this pathway may represent a chromatin regulatory mechanism that is broadly used across the genome. Overall d...
  5. Dynamics of nucleosome positioning maturation following genomic replication ArrayExpress

    ID: E-GEOD-79384

    Description: ts in the Hir1-delta background reveal a role for HIR in nucleosome spacing. Using strand-specific EdU libraries, we characterize nucleosome positions on the leading and lagging strand daughter genomes, uncovering differences in chromatin maturation dynamics between the two daughter genomes at hundreds of genes. Our data define the maturation dynamics of newly-replicated chromatin, and support a role for transcription in sculpting the chromatin template. Gene expression array....

  6. Differential Gene Expression in Cryptorchid Testes BioProject

    ID: PRJNA369019

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: sified as belonging to the high infertility risk (HIR) and eight to the low infertility risk (LIR) group. Cryptorchid boys in the high infertility risk group lacked transformation of gonocytes into Ad spermatogonia due to impaired mini puberty. This group of patients will be infertile despite successful surgery....
  7. Han Chinese Trio PacBio Whole Genome Sequencing : PacBio Whole Genome Sequencing to identify structural variation in Han Chinese Trio BioProject

    ID: PRJEB12236

    Keywords: Other

    Access Type: download

    dataset.description: ch and the practice of personalized medicine. UM HIR has run PacBio sequencing for one trio (Han Chinese, 40-fold effective sequence coverage for the child and 20x for both parents). The data is generated using P6C4 SMRT sequencing technology from insert libraries >20 kbp in length and a median read length >10 kbp....
  8. Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response ArrayExpress

    ID: E-GEOD-58812

    Description: immune response showed that high immune response (HIR) and low M2-like macrophages were a hallmark of C3, and that these patients had a better EFS than C2 patients, characterized by low immune response (LIR) and high M2-like macrophages: P = 0.02 for our cohort, and P = 0.03 for pooled cohorts. We identified 3 subtypes of TN patients: LAR (22%), basal-like with LIR and high M2-like macrophages (45%) and basal-enriched with HIR and low M2-like macrophages (33%). We pointed out that macrophages and other immune effectors offer a variety of therapeutic targets in breast cancer, and particularly in TN basal-like tumours. Furthermore, we showed that CK5 antibody was better suited than CK5/6 antibody to subtype TN patients. Subtyping molecular characterization within a cohort of 107 TN-IHC by means of gene expression profiling...

  9. Differential Gene Expression in Cryptorchid Testes BioProject

    ID: PRJNA369018

    Access Type: download

    dataset.description: sified as belonging to the high infertility risk (HIR) and eight to the low infertility risk (LIR) group. Cryptorchid boys in the high infertility risk group lacked transformation of gonocytes into Ad spermatogonia due to impaired mini puberty. This group of patients will be infertile despite successful surgery....
  10. A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription ArrayExpress

    ID: E-MTAB-2638

    Description: the histone chaperone Spt6, but not CAF-I, Asf1, HIR or Rtt106. Altogether, our data indicate that Spt6 controls H4 K16Ac levels by incorporating K16-unacetylated H4 in strongly transcribed genes. Upon repression, Spt6 association is decreased, resulting in less deposition of K16-unacetylated and therefore in a concomitant increase of H4 K16Ac that is recycled during transcription....

  11. HASP_SCHPO UniProt:Swiss-Prot

    ID: O13924

    Description: Serine/threonine-protein kinase haspin homolog hrk1 Protein kinase ATP Proton acceptor ATP

  12. HIR1_NEUCR UniProt:Swiss-Prot

    ID: Q7RZI0

    Description: Protein hir-1 WD 1 WD 2 WD 3 WD 4 WD 5 WD 6 WD 7 Poly-Glu

  13. Dynamics of nucleosome positioning maturation following genomic replication BioProject

    ID: PRJNA315674

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ts in the Hir1-delta background reveal a role for HIR in nucleosome spacing. Using strand-specific EdU libraries, we characterize nucleosome positions on the leading and lagging strand daughter genomes, uncovering differences in chromatin maturation dynamics between the two daughter genomes at hundreds of genes. Our data define the maturation dynamics of newly-replicated chromatin, and support a role for transcription in sculpting the chromatin template. Overall design: Gene expression array....
  14. Dynamics of chromatin maturation after genome replication BioProject

    ID: PRJNA298975

    Keywords: Epigenomics

    Access Type: download

    dataset.description: iments in the Hir1Δ background reveal a role for HIR in nucleosome spacing. Using strand-specific EdU libraries, we characterize nucleosome positions on the leading and lagging strand daughter genomes, uncovering differences in chromatin maturation dynamics between the two daughter genomes at hundreds of genes. Our data define the maturation dynamics of newly-replicated chromatin, and support a role for transcription in sculpting the chromatin template. Overall design: We have mapped changes in nucleosome positions on newly replicated DNA in a timecourse after genome replication. We have used Micrococcal Nuclease footprinting of cross linked chromatin to determine nucleosome positions and EdU (ethylene deoxy uridine) to mark nascent DNA strands. EdU incorporated into nascent DNA strands was biotinylated with Click chemistry and nascent DNA strand fragments were subsequently isolated using Streptavidin coated magnetic beads....
  15. Dynamics of chromatin maturation after genome replication ArrayExpress

    ID: E-GEOD-74090

    Description: iments in the Hir1Δ background reveal a role for HIR in nucleosome spacing. Using strand-specific EdU libraries, we characterize nucleosome positions on the leading and lagging strand daughter genomes, uncovering differences in chromatin maturation dynamics between the two daughter genomes at hundreds of genes. Our data define the maturation dynamics of newly-replicated chromatin, and support a role for transcription in sculpting the chromatin template. We have mapped changes in nucleosome positions on newly replicated DNA in a timecourse after genome replication. We have used Micrococcal Nuclease footprinting of cross linked chromatin to determine nucleosome positions and EdU (ethylene deoxy uridine) to mark nascent DNA strands. EdU incorporated into nascent DNA strands was biotinylated with Click chemistry and nascent DNA strand fragments were subsequently isolated using Streptavidin coated magnetic beads....

  16. Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response BioProject

    ID: PRJNA253922

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: immune response showed that high immune response (HIR) and low M2-like macrophages were a hallmark of C3, and that these patients had a better EFS than C2 patients, characterized by low immune response (LIR) and high M2-like macrophages: P = 0.02 for our cohort, and P = 0.03 for pooled cohorts. We identified 3 subtypes of TN patients: LAR (22%), basal-like with LIR and high M2-like macrophages (45%) and basal-enriched with HIR and low M2-like macrophages (33%). We pointed out that macrophages and other immune effectors offer a variety of therapeutic targets in breast cancer, and particularly in TN basal-like tumours. Furthermore, we showed that CK5 antibody was better suited than CK5/6 antibody to subtype TN patients. Overall design: Subtyping molecular characterization within a cohort of 107 TN-IHC by means of gene expression profiling...
  17. Differential Gene Expression in Cryptorchid Testes dbGaP

    ID: phs001275.v1.p1

    Description: sified as belonging to the high infertility risk (HIR) and eight to the low infertility risk (LIR) group. Cryptorchid boys in the high infertility risk group lacked transformation of gonocytes into Ad spermatogonia due to impaired mini puberty. This group of patients will be infertile despite successful surgery....

    Study Types: Case-Control

  18. Adipose tissue transcriptome in insulin resistance OmicsDI

    ID: E-GEOD-26637

    Date Released: 03-08-2012

    Description: g and after 3h hyperinsulinemia FIR x 5, FIS x 5, HIR x 5, HIS x 5 F=fasting, H=hyperinsulinemia, IR=Insulin-resistant, IS=Insulin-sensitive (FIR, FIS, HIR, HIS)...

  19. Crystal structure of mouse SAP18 residues 1-143 PDB

    ID: PDB:4A90

    Description: HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18

    dataset.creators: Ebert, J.
  20. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly PDB

    ID: PDB:2I32

    Description: ASF1a protein (Anti-Silencing Factor 1 paralog a), HIRA protein (Histone Regulatory homolog A)

    gene.name: HIRA, DGCR1, HIR, TUPLE1

Displaying 20 of 50 results for "KCNJ4"