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Displaying 17 of 17 results for "KCNH7"
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  1. ERG induced mesenchymal like gene signature ArrayExpress

    ID: E-GEOD-51258

    Description: ll line with a tet-on inducible plasmid habouring ERG3. Prolonged induction of ERG (8 days) produced spindle cell shape changes whereas non-induced cells retained the round morphology. In oder to determine the genes responsible for inducing ce...

  2. ERG induced mesenchymal like gene signature BioProject

    ID: PRJNA222990

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ll line with a tet-on inducible plasmid habouring ERG3. Prolonged induction of ERG (8 days) produced spindle cell shape changes whereas non-induced cells retained the round morphology. In oder to determine the genes responsible for inducing ce...
  3. Oncogene-Mediated Alterations in Chromatin Conformation ArrayExpress

    ID: E-GEOD-37752

    Description: al cell lines (RWPE1) that differ with respect to ERG3 over-expression. To test whether ERG over-expression is associated with global changes in chromatin structure, we performed unbiased chromatin interaction mapping using the Hi-C technique from both RWPE1-ERG and RWPE1-GFP cells, with biological replicates. Successful fill-in and ligation were determined as previously reported by testing for a known interaction between two distant genomic loci located on chromosome 6. The Hi-C libraries were paired-end sequenced using an Illumina GAIIx platform. Following alignment to the human genome (hg18) and filtering to remove un-ligated and self-ligated DNA, we identified intra-chromosomal (or cis-) and inter-chromosomal (or trans-) interactions in both RWPE1 cell lines. To characterize ERG binding and ERG-mediated gene expression changes in these cells, we performed chromatin-immunoprecipitation combined with high-throughput sequencing (ChIP-seq) and RNA sequencing (RNA-seq). ERG was bound to 6,398 sites in RPWE1-ERG cells. Based on paired-end RNA-seq data from both cell lines, 1,266 genes were differentially expressed between RWPE1-ERG and RWPE1-GFP cell lines....

  4. Expression Profiling of the Response to Short-Term Exposure to Fluconazole in Cryptococcus neoformans Serotype A ArrayExpress

    ID: E-GEOD-24927

    Description: thesis, including ERG13, ERG1, ERG7, ERG25, ERG2, ERG3, ERG5, and that encoding the azole target, ERG11, but also for the gene SRE1, that encodes a well-known regulator of sterol homeostasis in C. neoformans. In addition, several genes such as those involved in a wide variety of important cellular processes (i.e., lipid and fatty acid metabolism, cell wall maintenance, stress, virulence, etc.), were found to be up-regulated in response to fluconazole treatment. Some of these genes may represent potential therapeutic targets to be exploited in anticryptococcal therapy. Conversely, expression of AFR1, the major transporter of azoles in C. neoformans, was shown to be not affected by exposure to FLC, thus suggesting a minor involvement in the C. neoformans short-term adaptation to the azole drug. We studied the transient response of C. neoformans to fluconazole by analyzing differences in gene expression prior to and after exposure of strain H99....

  5. Expression Profiling of the Response to Short-Term Exposure to Fluconazole in Cryptococcus neoformans Serotype A BioProject

    ID: PRJNA131915

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: thesis, including ERG13, ERG1, ERG7, ERG25, ERG2, ERG3, ERG5, and that encoding the azole target, ERG11, but also for the gene SRE1, that encodes a well-known regulator of sterol homeostasis in C. neoformans. In addition, several genes such as those involved in a wide variety of important cellular processes (i.e., lipid and fatty acid metabolism, cell wall maintenance, stress, virulence, etc.), were found to be up-regulated in response to fluconazole treatment. Some of these genes may represent potential therapeutic targets to be exploited in anticryptococcal therapy. Conversely, expression of AFR1, the major transporter of azoles in C. neoformans, was shown to be not affected by exposure to FLC, thus suggesting a minor involvement in the C. neoformans short-term adaptation to the azole drug. Overall design: We studied the transient response of C. neoformans to fluconazole by analyzing differences in gene expression prior to and after exposur...
  6. Oncogene-Mediated Alterations in Chromatin Conformation BioProject

    ID: PRJNA163079

    Keywords: Other

    Access Type: download

    dataset.description: al cell lines (RWPE1) that differ with respect to ERG3 over-expression. To test whether ERG over-expression is associated with global changes in chromatin structure, we performed unbiased chromatin interaction mapping using the Hi-C technique from both RWPE1-ERG and RWPE1-GFP cells, with biological replicates. Successful fill-in and ligation were determined as previously reported by testing for a known interaction between two distant genomic loci located on chromosome 6. The Hi-C libraries were paired-end sequenced using an Illumina GAIIx platform. Following alignment to the human genome (hg18) and filtering to remove un-ligated and self-ligated DNA, we identified intra-chromosomal (or cis-) and inter-chromosomal (or trans-) interactions in both RWPE1 cell lines. To characterize ERG binding and ERG-mediated gene expression changes in these cells, we performed chromatin-immunoprecipitation combined with high-throughput sequencing (ChIP-seq) and RNA sequencing (RNA-seq). ERG was bound to 6,398 sites in RPWE1-ERG cells. Based on paired-end RNA-seq data from both cell lines, 1,266 genes were differentially expressed between RWPE1-ERG and RWPE1-GFP cell lines....
  7. ERG3_LEPMC UniProt:Swiss-Prot

    ID: Q8J207

    Description: Delta(7)-sterol 5(6)-desaturase Helical Helical Helical Helical Histidine box-1 Histidine box-2 Histidine box-3

  8. PRJNA361149 BioProject

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: hole genome sequencing revealed a mutation in the ERG3 gene leading to a G111R amino acid substitution in the resistant isolate. Subsequent introduction of this allele in the native ERG3 locus in the susceptible isolate resulted in a fluconazole MIC of >64 ug/ml and a caspofungin MIC of 8 ug/ml. Corresponding allelic replacement of the wildtype allele for the mutant allele in the resistant isolate resulted in a drop in MIC to 1 ug/ml for both flucon...
  9. ERG24_SEPLY UniProt:Swiss-Prot

    ID: O13597

    Description: Delta(14)-sterol reductase Helical Helical Helical Helical Helical Helical Helical Helical Helical Helical NADP NADP NADP NADP NADP; via amide nitroge...

    gene.name: ERG3
  10. ERG24_ASCIM UniProt:Swiss-Prot

    ID: P78575

    Description: Delta(14)-sterol reductase Helical Helical Helical Helical Helical Helical Helical Helical NADP NADP NADP NADP NADP; via amide nitrogen and carbonyl o...

    gene.name: ERG3
  11. 2303099 RGD

    Description: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb

    Creators: PhysGen, Transposagen,

    biologicalEntity.identifiers: F344-Kcnh7Tn(sb-T2/Bart3)2.295Mcwi
  12. ERG3_CANAX UniProt:Swiss-Prot

    ID: O93875

    Description: Delta(7)-sterol 5(6)-desaturase Helical Helical Helical Helical Histidine box-1 Histidine box-2 Histidine box-3

  13. Reciprocal BLASTP searches between fungal and kinetoplastid ERG25/ERG3 homologs. PeerJ

    ID: doi:10.7287/PEERJ.PREPRINTS.44V1/SUPP-2

    Release Date: 07-19-2013

    Creators: Cosentino, Raul O

  14. Reciprocal BLASTP searches between fungal and kinetoplastid ERG25/ERG3 homologs. PeerJ

    ID: doi:10.7287/PEERJ.PREPRINTS.44/SUPP-2

    Release Date: 07-19-2013

    Creators: Cosentino, Raul O

  15. ERG induced mesenchymal like gene signature OmicsDI

    ID: E-GEOD-51258

    Date Released: 07-23-2015

    Description: ll line with a tet-on inducible plasmid habouring ERG3. Prolonged induction of ERG (8 days) produced spindle cell shape changes whereas non-induced cells retained the round morphology. In oder to determine the genes responsible for inducing ce...

  16. Expression Profiling of the Response to Short-Term Exposure to Fluconazole in Cryptococcus neoformans Serotype A OmicsDI

    ID: E-GEOD-24927

    Date Released: 05-03-2014

    Description: thesis, including ERG13, ERG1, ERG7, ERG25, ERG2, ERG3, ERG5, and that encoding the azole target, ERG11, but also for the gene SRE1, that encodes a well-known regulator of sterol homeostasis in C. neoformans. In addition, several genes such as those involved in a wide variety of important cellular processes (i.e., lipid and fatty acid metabolism, cell wall maintenance, stress, virulence, etc.), were found to be up-regulated in response to fluconazole treatment. Some of these genes may represent potential therapeutic targets to be exploited in anticryptococcal therapy. Conversely, expression of AFR1, the major transporter of azoles in C. neoformans, was shown to be not affected by exposure to FLC, thus suggesting a minor involvement in the C. neoformans short-term adaptation to the azole drug. We studied the transient response of C. neoformans to fluconazole by analyzing differences in gene expression prior to and after exposure of strain H99....

  17. Oncogene-Mediated Alterations in Chromatin Conformation OmicsDI

    ID: E-GEOD-37752

    Date Released: 05-03-2014

    Description: al cell lines (RWPE1) that differ with respect to ERG3 over-expression. To test whether ERG over-expression is associated with global changes in chromatin structure, we performed unbiased chromatin interaction mapping using the Hi-C technique from both RWPE1-ERG and RWPE1-GFP cells, with biological replicates. Successful fill-in and ligation were determined as previously reported by testing for a known interaction between two distant genomic loci located on chromosome 6. The Hi-C libraries were paired-end sequenced using an Illumina GAIIx platform. Following alignment to the human genome (hg18) and filtering to remove un-ligated and self-ligated DNA, we identified intra-chromosomal (or cis-) and inter-chromosomal (or trans-) interactions in both RWPE1 cell lines. To characterize ERG binding and ERG-mediated gene expression changes in these cells, we performed chromatin-immunoprecipitation combined with high-throughput sequencing (ChIP-seq) and RNA sequencing (RNA-seq). ERG was bound to 6,398 sites in RPWE1-ERG cells. Based on paired-end RNA-seq data from both cell lines, 1,266 genes were differentially expressed between RWPE1-ERG and RWPE1-GFP cell lines....


Displaying 17 of 17 results for "KCNH7"