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Displaying 20 of 27 results for "ITPR3"
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  1. Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor PDB

    ID: PDB:3JRR

    Description: Inositol 1,4,5-trisphosphate receptor type 3

  2. ITPR3_RAT UniProt:Swiss-Prot

    ID: Q63269

    Description: Inositol 1,4,5-trisphosphate receptor type 3

  3. ITPR3_BOVIN UniProt:Swiss-Prot

    ID: Q8WN95

    Description: Inositol 1,4,5-trisphosphate receptor type 3

  4. ITPR2_BOVIN UniProt:Swiss-Prot

    ID: Q8WN96

    Description: Inositol 1,4,5-trisphosphate receptor type 2 Cytoplasmi...

  5. Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3 PDB

    ID: PDB:1N4K

    Description: Inositol 1,4,5-trisphosphate receptor type 1, D-MYO-

  6. Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor PDB

    ID: PDB:3T8S

    Description: Inositol 1,4,5-trisphosphate receptor type 1

  7. Expression data from mouse amygdala BioProject

    ID: PRJNA309237

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in...
  8. Expression data from mouse amygdala ArrayExpress

    ID: E-GEOD-77001

    Description: Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in...

  9. Expression data from from the E9.25 hearts of mouse embryos BioProject

    ID: PRJNA139545

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: re, we analyzed mice deficient for genes encoding inositol 1,4,5-trisphosphate receptors (IP3Rs), which are intracellular Ca2+ release channels on the endo/sarcoplasmic reticulum that mediate Ca2+ mobilization. Mouse embryos that are double mutant for IP3R type 1 and type 3 (IP3R1−/−IP3R3−/−) show hypoplasia of the outflow tract and the right ventricle, reduced expression of specific molecular markers and enhanced apoptosis ofmesodermal cells in the SHF. Gene expression analyses suggest that IP3R-mediated Ca2+ signalingmay involve, at least in part, theMef2C–Smyd1 pathway, a transcriptional cascad...
  10. Expression data from from the E9.25 hearts of mouse embryos ArrayExpress

    ID: E-GEOD-28186

    Description: re, we analyzed mice deficient for genes encoding inositol 1,4,5-trisphosphate receptors (IP3Rs), which are intracellular Ca2+ release channels on the endo/sarcoplasmic reticulum that mediate Ca2+ mobilization. Mouse embryos that are double mutant for IP3R type 1 and type 3 (IP3R1−/−IP3R3−/−) show hypoplasia of the outflow tract and the right ventricle, reduced expression of specific molecular markers and enhanced apoptosis ofmesodermal cells in the SHF. Gene expression analyses suggest that IP3R-mediated Ca2+ signalingmay involve, at least in part, theMef2C–Smyd1 pathway, a transcriptional cascad...

  11. Transcription profiling of human monocytes reveals leukotriene D4 induces gene expression through cysteinyl leukotriene type I receptor ArrayExpress

    ID: E-GEOD-7807

    Description: chemotaxis assays. Results: Cysteinyl leukotriene type I receptor (CysLTR1) transcript 1 is predominantly expressed in human monocytes and cysLTs signal through CysLTR1 in these cells. Several immediate-early genes, including early growth response (Egr) -2, 3, FosB, activating transcription factor 3 and nuclear receptor subfamily 4 were significantly induced by LTD4. This effect was mediated by CysLTR1 coupled to Gαi/o, activation of phospholipase C, and inositol-1,4,5-triphosphate (IP3) and store operated calcium channels. LTD4 induced p38 MAP kinase phosphorylation, a pathway also involved in the regulation of immediate-early genes expression in monocytes. LTD4 stimulated monocyt...

  12. Expression data from mouse amygdala OmicsDI

    ID: E-GEOD-77001

    Date Released: 01-23-2016

    Description: Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in...

  13. Leukotriene D4 induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. BioProject

    ID: PRJNA100025

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. The Genetic Landscape of Metastasis and Recurrence in HNSCC BioProject

    ID: PRJNA299346

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: their respective primaries, including C17orf104, ITPR3, and DDR2. DDR2 mutations have been shown to confer enhanced sensitivity to Src-family kinase (SFK) inhibitors in other malignancies. Similarly, we found HNSCC cell lines harboring endogenous and engineered... (for more see dbGaP study page.)...
  15. Homo sapiens : The Genetic Landscape of Metastasis and Recurrence in HNSCC BioProject

    ID: PRJNA299345

    Access Type: download

    dataset.description: their respective primaries, including C17orf104, ITPR3, and DDR2. DDR2 mutations have been shown to confer enhanced sensitivity to Src-family kinase (SFK) inhibitors in other malignancies. Similarly, we found HNSCC cell lines harboring endogenous and engineered... (for more see dbGaP study page.)...
  16. Transduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation ArrayExpress

    ID: E-GEOD-25965

    Description: HDGF and IGF2 were up- and MAPK9, PIK3CA, FRAT2, ITPR3, CDH6, HIPK1 and TIMP3 were down-regulated in WT respectively. Hierarchical clustering based on the expression of this gene set grouped DK from both species, human and mouse, and discriminated them from fetal kidney and WT in human, and the earliest kidney stages in mouse, validating the model proposed by this study and reveling a transduction signaling signature of WT. High robustness of this data was detected since expression level was tested by quantitative RT-PCR in the initial and independent sample set, with 75 and 56% of agreement. Agreement of 62% was also observed in protein level assessing blastemal component of an independent group of 137 WT. Protein expression of CRABP2, IGF2, GRK7, TESK1, HDGF, WNT5B, FZD2 and TIMP3 was also characterized in human fetal kidneys revealing interesting aspects of kidney differentiation. This study identified key genes modulated during kidney differentiation which may play a determinant role for WT onset. As far as we know, FZD10, FRZB, HDGF, MAPK9, FRAT2, SHPK, WNT5B, GRK7, TESK1, HDGF, PIK3CA, ITPR3, HIPK1 and TIMP3 were not previously associated to WT. The strong connection between nephrogenesis and WT highlights the importance of a detailed characterization of modulated genes belonged to signal transduction. Identification of gene expression invo...

  17. TRPC4_BOVIN UniProt:Swiss-Prot

    ID: P79100

    Description: Short transient receptor potential channel 4 Cytoplasmic Helical Extracellular Helical Cytoplasmic Helical Extracellular Helical Cytoplasmic Helica...

  18. TRPV4_RAT UniProt:Swiss-Prot

    ID: Q9ERZ8

    Description: Transient receptor potential cation channel subfamily V member 4 Cytoplasmic Helical Extracellular Helical Cytoplasmic Helical Extracellular ...

  19. The Genetic Landscape of Metastasis and Recurrence in HNSCC dbGaP

    ID: phs001007.v1.p1

    Description: their respective primaries, including C17orf104, ITPR3, and DDR2. DDR2 mutations have been shown to confer enhanced sensitivity to Src-family kinase (SFK) inhibitors in other malignancies. Similarly, we found HNSCC cell lines harboring endogenous and engineered DDR2 mutations to be more sensitive to the SFK inhibitor dasatinib, than those with WT DDR2. This study outlines the first compendium of somatic mutations in primary, metastatic and/or recurrent HNSCC cancers that arise in individual patients; and demonstrates how such data can be used to interrogate potential predictive/prognostic biomarkers to inform and guide personalized therapy....

    Study Types: Case Set

  20. Transduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation BioProject

    ID: PRJNA135435

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HDGF and IGF2 were up- and MAPK9, PIK3CA, FRAT2, ITPR3, CDH6, HIPK1 and TIMP3 were down-regulated in WT respectively. Hierarchical clustering based on the expression of this gene set grouped DK from both species, human and mouse, and discriminated them from fetal kidney and WT in human, and the earliest kidney stages in mouse, validating the model proposed by this study and reveling a transduction signaling signature of WT. High robustness of this data was detected since expression level was tested by quantitative RT-PCR in the initial and independent sample set, with 75 and 56% of agreement. Agreement of 62% was also observed in protein level assessing blastemal component of an independent group of 137 WT. Protein expression of CRABP2, IGF2, GRK7, TESK1, HDGF, WNT5B, FZD2 and TIMP3 was also characterized in human fetal kidneys revealing interesting aspects of kidney differentiation. This study identified key genes modulated during kidney differentiation which may play a determinant role for WT onset. As far as we know, FZD10, FRZB, HDGF, MAPK9, FRAT2, SHPK, WNT5B, GRK7, TESK1, HDGF, PIK3CA, ITPR3, HIPK1 and TIMP3 were not previously associated to WT. Overall design: The strong connection between nephrogenesis and WT highlights the importance of a detailed characterization of modulated genes belonged to signal transduction. Identification of gene...

Displaying 20 of 27 results for "ITPR3"