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Displaying 20 of 55 results for "ITGB5"
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  1. ITB5_PAPCY UniProt:Swiss-Prot

    ID: Q07441

    Description: Integrin beta-5 Extracellular Helical Cytoplasmic VWFA I II III IV Cysteine-rich tandem repea...

  2. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [eCLIP-Seq] ArrayExpress

    ID: E-GEOD-78507

    Description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...

  3. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [RNA-Seq] ArrayExpress

    ID: E-GEOD-78508

    Description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...

  4. 3SPM_DENJA UniProt:Swiss-Prot

    ID: P28375

    Description: induced platelet aggregation This mutation alters integrin binding selectivity. It provokes 95-fold loss of ability to inhibit ADP-induced platelet aggregation, 71-fold loss of ability to inhibit A375 cell adhesion to fibrinogen, and almost complete loss of ability to inhibit HEL cell adhesion to fibrinogen This mut...

  5. Integrin beta 5 qPCR results PeerJ

    ID: doi:10.7287/PEERJ.PREPRINTS.1514V1/SUPP-16

    Release Date: 11-17-2015

    Creators: Marycz, Krzysztof

  6. Integrin beta 5 qPCR results PeerJ

    ID: doi:10.7287/PEERJ.PREPRINTS.1514/SUPP-16

    Release Date: 11-17-2015

    Creators: Marycz, Krzysztof

  7. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [RNA-Seq] BioProject

    ID: PRJNA313161

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. Overall design: eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...
  8. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [eCLIP-Seq] BioProject

    ID: PRJNA313162

    Keywords: Other

    Access Type: download

    dataset.description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. Overall design: eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...
  9. Expression data from chick embryonic midbrain over-expressing constitutively active integrin-beta 1 in a hetergenous manner. BioProject

    ID: PRJNA244122

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment PDB

    ID: PDB:3IJE

    Description: Integrin alpha-V, Integrin beta-3

  11. Chronic inflammation and carcinogenesis caused by intestinal specific ablation of integrin alpha6 beta4 OmicsDI

    ID: E-GEOD-37749

    Date Released: 07-07-2016

    Description: e, in which inactivation of the gene encoding the integrin alpha-6 subunit (ITGA6) specifically in the intestinal mucosa results into chronic inflammation and intestinal carcinogenesis. In these mice, the loss of integrin alpha-6 beta-4, a receptor mediating the attachment of epithelial cells to laminins, leads to epithelial detachment, hyperplasia, chronic inflammation, rectal prolapses, and ultimately adenocarcinomas. Alterations of differentiation affecting mucus secreting (goblet) cells as well as changes in expression of essential intestinal transcription factors were detected. Thus alpha-6 beta-4 integrin is a key factor for the maintenance of intestinal integrity and its loss may repres...

  12. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WK4

    Description: Integrin alpha5, Integrin beta1, ALA-CYS-ARG-GLY-ASP-GLY-TRP-CYS

  13. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WJK

    Description: Integrin alpha5, Integrin beta1

  14. Chronic inflammation and carcinogenesis caused by intestinal specific ablation of integrin alpha6 beta4 ArrayExpress

    ID: E-GEOD-37749

    Description: e, in which inactivation of the gene encoding the integrin alpha-6 subunit (ITGA6) specifically in the intestinal mucosa results into chronic inflammation and intestinal carcinogenesis. In these mice, the loss of integrin alpha-6 beta-4, a receptor mediating the attachment of epithelial cells to laminins, leads to epithelial detachment, hyperplasia, chronic inflammation, rectal prolapses, and ultimately adenocarcinomas. Alterations of differentiation affecting mucus secreting (goblet) cells as well as changes in expression of essential intestinal transcription factors were detected. Thus alpha-6 beta-4 integrin is a key factor for the maintenance of intestinal integrity and its loss may repres...

  15. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [eCLIP-Seq] OmicsDI

    ID: E-GEOD-78507

    Date Released: 04-08-2016

    Description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...

  16. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival [RNA-Seq] OmicsDI

    ID: E-GEOD-78508

    Date Released: 04-08-2016

    Description: hesion, in hPSCs we find IMP1 maintains levels of integrin mRNA, specifically regulating RNA stability of ITGB5. Additionally, we show IMP1 can be linked to hPSC survival via direct target BCL2. Thus, transcriptome-wide binding profiles identify hPSC targets modulating well-characterized IMP1 roles. eCLIP-seq was performed in biological replicate for IGF2BP1/IMP1 and IGF2BP2/IMP2, as well as one replicate each for IGF2BP3/IMP3, RBFOX2, and an IgG control. Each sample has a size-matched input control for analysis...

  17. Gene profile of breast cancers with immunohistochemical phenotypes of ER+/- and/or HER2+/- BioProject

    ID: PRJNA99585

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: DA), and underexpressed genes were nine including ITGB5, KIAA0310, MAGED2, PRSS11, SORL1, TGFB3, KRT18, CPE, BCAS1. No gene was directly related to cell proliferation such as cyclins, cyclin-dependent kinase, p53, p16, and the pRb and p21 families. We had a particular focus on a transcriptional factor E2F-5 from a list of genes overexpressed in ER negative breast cancers compared to ER positive breast cancers, and further examined. Gene amplification of E2F-5 was detected in 5/57 (8.8%) in breast cancers by FISH. No point mutation was found at the binding domain with DNA or dimerization partner of E2F-5. Immunohistochemically E2F-5 positive cancers were more frequent in ER(-)/HER2(-) cancer (14/27, 51.9%) than in other types of cancer (5/30, 16.7%) (p=0.05). E2F-5 positive cancers had higher Ki-67 labeling index (59.5%) than E2F-5 negative cancers (36.3%). E2F-5 positive cancers showed higher histological grade including metaplastic carcinoma, and worse clinical outcome with shorter disease free survival in node negative patients. In conclusion, we demonstrated that there is a population of breast cancer with overexpression of a cell cycle related transcriptional factor E2F-5. E2F-5 positive breast cancers were frequent i...
  18. The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening PDB

    ID: PDB:3NIF

    Description: Integrin alphaIIB beta3, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal an...

  19. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WK2

    Description: Integrin alpha5, Integrin beta1, GLY-ARG-GLY-ASP-SER-PRO

  20. Data from: Combining GWAS and RNA-seq approaches for detection of the causal mutation for hereditary junctional epidermolysis bullosa in sheep Dryad

    DateIssued: 08-18-2015

    Description: in a premature stop codon at position 1472 of the integrin β4 protein. A functional analysis of this deletion revealed decreased levels of mRNA in JEB skin samples and the absence of integrin β4 labeling in immunohistochemical assays. Genotyping of c.4412_4415del showed perfect concordance with the recessive mode of the disease phenotype. Selection against this causal mutation will now be used to solve the problem of JEB in flocks of Churra sheep. Furthermore, the identification of the ITGB4 mutation means that affected sheep can be used as a large mammal animal model for the human form of epidermolysis bullosa with aplasia cutis. Our approach evidences that RNA-seq offers cost-effective alternative to identify variants in the species in which high resolution exome-sequencing is not straightforward....


Displaying 20 of 55 results for "ITGB5"