ITGB2 | bioCADDIE Data Discovery Index
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Displaying 20 of 40 results for "ITGB2"
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  1. ITB2_XENLA UniProt:Swiss-Prot

    ID: Q09062

    Description: Integrin beta-2 N-linked (GlcNAc...)

    gene.name: itgb2
  2. Bone marrow micro-environment mediated drug resistance in Acute promyelocytic leukemia ArrayExpress

    ID: E-GEOD-73157

    Description: tion of various pathways such as adhesion (ITGB1, ITGB2, ITGB7, etc.), Cytokines (IL-6, IL-8, IL-18, CCL2, CCL10, etc.) Wnt signalling (Wnt5a, Wnt11, NFATC4, etc,) NF-kB pathway (ICAM1, BIRC2, BIRC3, XIAP1, etc.) in the leukemic cells. The NF-kB pathway has been validated using real time PCR which correlated with the genes being differentially regulated in NB4 cells co-cultured in stroma. Agilent one-color experiment,Organism: Homo sapiens ,Custom Agilent 8x60k Human Whole Genome Microarray Gene expression (AMADID: 039494) , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)...

  3. VP7_ROTS1 UniProt:Swiss-Prot

    ID: P03533

    Description: lycoprotein VP7 GPR motif; interaction with ITGAX/ITGB2 heterodimer N-linked (GlcNAc...) (high mannose); by host In isoform 2. (in Ref. 2; AAA47307) (in Ref. 2; AAA47307) (in Ref. 2; AAA47307) (i...

  4. Analysis of Meniscal Degeneration and Meniscal Gene Expression ArrayExpress

    ID: E-GEOD-19060

    Description: lass II, DP alpha 1 (HLA-DPA1), integrin, beta 2 (ITGB2), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), ankylosis, progressive homolog (ANKH) and fibroblast growth factor 7 (FGF7), were expressed at higher levels compared to normal control meniscal cells. In addition, many genes that were previously implicated in OA were also expressed at higher levels in OA meniscal cells, including ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5). Our findings suggest that OA is a whole joint disease. Meniscal cells may play an active role in the development of OA. Investigation of the gene expression profiles of OA meniscal cells may reveal new therapeutic targets for OA therapy and also may uncover novel disease markers for early diagnosis of OA. Studies were approved by our human subjects Institutional Review Board. Menisci and articular cartilage were collected during joint replacement surgery for OA patients (OA specimens) and lower limb amputation surgery for osteosarcoma patients (normal control specimens), and graded. Meniscal cells were prepared from the meniscal tissues and expanded i...

  5. Juvenile obesity in Ossabaw swine produces artery-specific transcriptional changes ArrayExpress

    ID: E-GEOD-41636

    Description: ng ACP5, LYZ, CXCL14, APOE, PLA2G7, LGALS3, SPP1, ITGB2, CYBB, and P2RY12. Furthermore, pathway analysis revealed the induction of pro-inflammatory and pro-oxidant pathways with obesity primarily in the LAD. Gene expression in the LAD perivascular fat was minimally altered with juvenile obesity. Together, we provide new evidence that obesity produces artery-specific changes in pre-translational regulation with a clear up-regulation of pro-atherogenic genes in the LAD. Our data may offer potential viable drug targets and mechanistic insights regarding the molecular precursors involved in the origins of over-nutrition and obesity-associated vascular disease. In particular, our results suggest that the oxLDL-LOX-1-NFκB signaling axis may be involved in the early initiation of a juvenile obesity-induced pro-atherogenic coronary artery phenotype. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n=5) and lean (n=6) juvenile Ossabaw pigs (age= 22 weeks). ...

  6. RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION PDB

    ID: PDB:5ES4

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  7. Integrative Epigenome-Wide Analysis Shows That DNA Methylation May Mediate Genetic Risk In Inflammatory Bowel Disease [Expression profiling] BioProject

    ID: PRJNA341861

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2, TXK) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci; VMP1/microRNA-21 methylation associates with two genetic polymorphisms in linkage disequilibrium with a known IBD susceptibility variant. Separated cell data highlight the cell type of origin of epigenetic signals seen in whole blood; IBD-associated hypermethylation within the TXK gene transcription start-sitepromoter region negatively correlates with gene expression in whole blood and CD8+ T-cells, but not oth...
  8. An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 PDB

    ID: PDB:4NEN

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  9. An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 PDB

    ID: PDB:4NEH

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  10. Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit PDB

    ID: PDB:5E6V

    Description: Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  11. Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand PDB

    ID: PDB:5E6R

    Description: Integrin alpha-L, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  12. Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit PDB

    ID: PDB:5E6X

    Description: Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  13. Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand PDB

    ID: PDB:5E6U

    Description: Integrin alpha-L, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  14. Structure of integrin alphaX beta2 PDB

    ID: PDB:3K72

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: CD18, ITGB2, MFI7
  15. Structure of integrin alphaX beta2 ectodomain PDB

    ID: PDB:3K71

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: CD18, ITGB2, MFI7
  16. Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit PDB

    ID: PDB:5E6W

    Description: Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  17. Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand PDB

    ID: PDB:5E6S

    Description: Integrin alpha-L, Integrin beta-2

    gene.name: ITGB2, CD18, MFI7
  18. Structure of integrin alphaXbeta2 ectodomain PDB

    ID: PDB:3K6S

    Description: Integrin alpha-X, Integrin beta-2

    gene.name: CD18, ITGB2, MFI7
  19. Identification of CD44 downstream target genes OmicsDI

    ID: E-GEOD-43104

    Date Released: 06-02-2014

    Description: lar matrix proteins (Integrin α4 (Itga4), ItgaM, Itgb2), were decreased in WAT of CD44(HFD) compared to WT(HFD) mice. This study indicates that CD44 plays a critical role in regulating several aspects of metabolic syndrome. Liver and white adipose tissue (WAT) total RNAs were purified from 5 WT and 5 CD44 knockout mice fed with a high-fat diet for 21 weeks. Then, samples were applied on Agilent mouse genome chips....

  20. Identification of CD44 downstream target genes ArrayExpress

    ID: E-GEOD-43104

    Description: lar matrix proteins (Integrin α4 (Itga4), ItgaM, Itgb2), were decreased in WAT of CD44(HFD) compared to WT(HFD) mice. This study indicates that CD44 plays a critical role in regulating several aspects of metabolic syndrome. Liver and white adipose tissue (WAT) total RNAs were purified from 5 WT and 5 CD44 knockout mice fed with a high-fat diet for 21 weeks. Then, samples were applied on Agilent mouse genome chips....


Displaying 20 of 40 results for "ITGB2"