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Displaying 20 of 26 results for "ITGA5"
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  1. Transcription profiling of human bone marrow mesenchymal stromal cells before and after stimulation with dexamethasone to study the early molecular pr... ArrayExpress

    ID: E-GEOD-18043

    Description: riptomic analysis, we found that integrin alpha5 (ITGA5) expression is upregulated during dexamethasone-induced hMSCs osteoblast differentiation. Gain-of-function studies showed that ITGA5 promotes the expression of osteoblast phenotypic markers as well as in vitro osteogenesis in hMSCs. Downregulation of endogenous ITGA5 using shRNA blunted osteoblast marker expression and osteogenic differentiation. Pharmacological and molecular analyses showed that the enhanced hMSCs osteoblast...

  2. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis BioProject

    ID: PRJNA119295

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: riptomic analysis, we found that integrin alpha5 (ITGA5) expression is upregulated during dexamethasone-induced hMSCs osteoblast differentiation. Gain-of-function studies showed that ITGA5 promotes the expression of osteoblast phenotypic markers as well as in vitro osteogenesis in hMSCs. Downregulation of endogenous ITGA5 using shRNA blunted osteoblast marker expression and osteogenic differentiation. Pharmacological and molecular analyses showed that the enhanced hMSCs osteoblast...
  3. Transcription profiling of human bone marrow mesenchymal stromal cells before and after stimulation with dexamethasone to study the early molecular pr... OmicsDI

    ID: E-GEOD-18043

    Date Released: 06-10-2011

    Description: riptomic analysis, we found that integrin alpha5 (ITGA5) expression is upregulated during dexamethasone-induced hMSCs osteoblast differentiation. Gain-of-function studies showed that ITGA5 promotes the expression of osteoblast phenotypic markers as well as in vitro osteogenesis in hMSCs. Downregulation of endogenous ITGA5 using shRNA blunted osteoblast marker expression and osteogenic differentiation. Pharmacological and molecular analyses showed that the enhanced hMSCs osteoblast...

  4. elapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1... ArrayExpress

    ID: E-GEOD-26666

    Description: argets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110α, NRAS as well as CSF1, a growth factor for stroma cells. Our findings reveal the importance of the identified 16 miRs for disease outcome predictions and suggest a critical role for miR-148b in the control of breast cancer progression. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series....

  5. elapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1... OmicsDI

    ID: E-GEOD-26666

    Date Released: 08-11-2015

    Description: argets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110α, NRAS as well as CSF1, a growth factor for stroma cells. Our findings reveal the importance of the identified 16 miRs for disease outcome predictions and suggest a critical role for miR-148b in the control of breast cancer progression. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series....

  6. Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (methylation) ArrayExpress

    ID: E-GEOD-41336

    Description: set of functionally important genes including CP, ITGA5, SOD2, XDH and ZNF2. Intriguingly, 70 out of the 147 hypoxia-associated CpGs, overlapped with CpG sites that become hypomethylated upon differentiation of cytotrophoblasts into syncytiotrophoblasts. Furthermore, the preponderance of altered sites was located at AP-1 binding sites. We suggest that AP-1 expression is triggered by hypoxia and interacts with DNA methyltransferases (DNMTs) to target methylation at specific sites in the genome, thus causing suppression of the associated genes that are responsible for differentiation of villous cytotrophoblast to syncytiotrophoblast. DNA from 2 cell types from 5 placentas exposed to 3 different conditions of hypoxia (1%,8%,20%) and treated with 3 levels of vitamin D were bisulfite converted and run on the Illumina HumanMethylation450 BeadChip...

  7. Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (expression) ArrayExpress

    ID: E-GEOD-41331

    Description: set of functionally important genes including CP, ITGA5, SOD2, XDH and ZNF2. Intriguingly, 70 out of the 147 hypoxia-associated CpGs, overlapped with CpG sites that become hypomethylated upon differentiation of cytotrophoblasts into syncytiotrophoblasts. Furthermore, the preponderance of altered sites was located at AP-1 binding sites. We suggest that AP-1 expression is triggered by hypoxia and interacts with DNA methyltransferases (DNMTs) to target methylation at specific sites in the genome, thus causing suppression of the associated genes that are responsible for differentiation of villous cytotrophoblast to syncytiotrophoblast. RNA from cytotrophoblast from 2 placentas exposed to 3 different conditions of hypoxia (1%,8%,20%) and treated with 3 levels of vitamin D were run on the Illumina HT-12v4 Expression Array...

  8. PRJNA136411 BioProject

    Access Type: download

    dataset.description: argets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110α, NRAS as well as CSF1, a growth factor for stroma cells. Our findings reveal the importance of the identified 16 miRs for disease outcome predictions and suggest a critical role for miR-148b in the control of breast cancer progression. This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series....
  9. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis (D4 post-wound) BioProject

    ID: PRJNA361400

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e then FACS sorted for the positive expression of ITGA5, the 6mm punched samples where then FACS sorted for negative expression of ITGA5. The three replicates samples at each time point were a pull of 5 CD1 mice. For each sample, 300 basal cells were FACS sorted and used for RNA extraction and hybridization on Affymetrix microarrays....
  10. Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (methylation) BioProject

    ID: PRJNA176597

    Keywords: Epigenomics

    Access Type: download

    dataset.description: set of functionally important genes including CP, ITGA5, SOD2, XDH and ZNF2. Intriguingly, 70 out of the 147 hypoxia-associated CpGs, overlapped with CpG sites that become hypomethylated upon differentiation of cytotrophoblasts into syncytiotrophoblasts. Furthermore, the preponderance of altered sites was located at AP-1 binding sites. We suggest that AP-1 expression is triggered by hypoxia and interacts with DNA methyltransferases (DNMTs) to target methylation at specific sites in the genome, thus causing suppression of the associated genes that are responsible for differentiation of villous cytotrophoblast to syncytiotrophoblast. Overall design: DNA from 2 cell types from 5 placentas exposed to 3 different conditions of hypoxia (1%,8%,20%) and treated with 3 levels of vitamin D were bisulfite converted and run on the Illumina HumanMethylation450 BeadChip...
  11. miRNA-mediated expression switch of cell adhesion genes driven by microcirculation in chip BioProject

    ID: PRJNA322822

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: wn-regulated genes (COL12A1, FGA, FGB, FGG, GJA1, ITGA5 and LAMA1) and 69 miRNAs targeting them under the influence of microcirculation. The revealed network comprised CAM genes known to interact with each other and 13 miRNAs simultaneously regulating more than one of them. Overall design: Undifferentiated Caco2 cells were seeded on individual polyether membrane inserts with 0.143 cm2 surface area and 1.0 μm pore diameter, cut out from HTS Transwell®-96 well permeable support (Corning Inc., USA), with cell density approximately 60,000 cells/well. The cells were incubated under conditions for differentiation for 7 days in MEM with 10% FBS, 0.1 mM non-essential aminoacids, 0.1% penicillin-streptomycin in 5% CO2, 37° C, changed three times. Transwell® inserts wit...
  12. NISCH_RAT UniProt:Swiss-Prot

    ID: Q4G017

    Description: with PAK1 Interaction with LIMK Interaction with ITGA5 Glu-rich Ala/Pro-rich Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine...

  13. ITA5_BOVIN UniProt:Swiss-Prot

    ID: Q27977

    Description: Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain Extracellular Helical Cytoplasmic N-linked (GlcNAc...) N-linked (GlcNAc...)...

    gene.name: ITGA5
  14. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WK2

    Description: Integrin alpha5, Integrin beta1, GLY-ARG-GLY-ASP-SER-PRO

    gene.name: ITGA5, FNRA
  15. Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (expression) BioProject

    ID: PRJNA176596

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: set of functionally important genes including CP, ITGA5, SOD2, XDH and ZNF2. Intriguingly, 70 out of the 147 hypoxia-associated CpGs, overlapped with CpG sites that become hypomethylated upon differentiation of cytotrophoblasts into syncytiotrophoblasts. Furthermore, the preponderance of altered sites was located at AP-1 binding sites. We suggest that AP-1 expression is triggered by hypoxia and interacts with DNA methyltransferases (DNMTs) to target methylation at specific sites in the genome, thus causing suppression of the associated genes that are responsible for differentiation of villous cytotrophoblast to syncytiotrophoblast. Overall design: RNA from cytotrophoblast from 2 placentas exposed to 3 different conditions of hypoxia (1%,8%,20%) and treated with 3 levels of vitamin D were run on the Illumina HT-12v4 Expression Array...
  16. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WK4

    Description: Integrin alpha5, Integrin beta1, ALA-CYS-ARG-GLY-ASP-GLY-TRP-CYS

    gene.name: ITGA5, FNRA
  17. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WJK

    Description: Integrin alpha5, Integrin beta1

    gene.name: ITGA5, FNRA
  18. Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide PDB

    ID: PDB:3VI4

    Description: Integrin alpha-5, Integrin beta-1, SG/19 Fab fragment (Light chain), SG/19 Fab fragment (Heavy chain), RGD peptide

    gene.name: FNRA, ITGA5
  19. Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) PDB

    ID: PDB:3VI3

    Description: Integrin alpha-5, Integrin beta-1, SG/19 Fab fragment (Light chain), SG/19 Fab fragment (Heavy chain)

    gene.name: FNRA, ITGA5
  20. Metal Ion and Ligand Binding of Integrin PDB

    ID: PDB:4WK0

    Description: Integrin alpha5, Integrin beta1, ARG-GLY-ASP

    gene.name: ITGA5, FNRA

Displaying 20 of 26 results for "ITGA5"