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Displaying 20 of 102 results for "IRS1"
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  1. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus BioProject

    ID: PRJNA142385

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Gene expression data from adipocytes of insulin resistant mice ArrayExpress

    ID: E-GEOD-76428

    Description: ne expression data obtained from a mouse model of insulin resistance progression. Both genetic aspects and dietary factors, specifically high caloric high-fat high-sugar diets, contribute to the progression of insulin resistance. To mimic genetic predisposition, we used a mouse model wi...

  3. Transcription profiling of mouse liver cells with liver specific deletion of Irs1 and/or Irs2 and Foxo1during fasting and feeding OmicsDI

    ID: E-MEXP-1649

    Date Released: 05-02-2014

    Description: The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon ge...

  4. Transcription profiling of mouse liver cells with liver specific deletion of Irs1 and/or Irs2 and Foxo1during fasting and feeding ArrayExpress

    ID: E-MEXP-1649

    Description: The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon ge...

  5. Gene expression data from adipocytes of insulin resistant mice OmicsDI

    ID: E-GEOD-76428

    Date Released: 01-01-2016

    Description: ne expression data obtained from a mouse model of insulin resistance progression. Both genetic aspects and dietary factors, specifically high caloric high-fat high-sugar diets, contribute to the progression of insulin resistance. To mimic genetic predisposition, we used a mouse model wi...

  6. Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid PDB

    ID: PDB:2Z8C

    Description: Insulin receptor (E.C.2.7.10.1), Insulin receptor substrate

  7. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus OmicsDI

    ID: E-GEOD-26167

    Date Released: 12-18-2010

    Description: as significantly higher than in healthy controls. Insulin receptor substrate 1 (IRS1) has been predicted to be a potential target of miR-144. Consistent with this observation, IRS1 mRNA and protein levels, verified by quantitative real-time PCR and western blotting respectively, were found to be down-regulated. Using luciferase assay, we further demonstrated that miR-144 directly targets IRS1 and showed its effects on protein expression via immunocytochemistry. From this cross-sectional study in humans, we have identified signature miRNAs which could explain the pathogenesis of T2D. Whether miRNAs like miR-144 could be potential therapeutic targets for management of T2D will need to be explored by further mechanistic and functional studies. miRNA profiling of tissues from T2D rat models. Total RNA (plus miRNAs) was isolated using a modification of the RiboPure™-Blood kit from Ambion (Austin,TX) according to the manufacturer’s protocol. The concentration of total RNA and ...

  8. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus ArrayExpress

    ID: E-GEOD-26167

    Description: as significantly higher than in healthy controls. Insulin receptor substrate 1 (IRS1) has been predicted to be a potential target of miR-144. Consistent with this observation, IRS1 mRNA and protein levels, verified by quantitative real-time PCR and western blotting respectively, were found to be down-regulated. Using luciferase assay, we further demonstrated that miR-144 directly targets IRS1 and showed its effects on protein expression via immunocytochemistry. From this cross-sectional study in humans, we have identified signature miRNAs which could explain the pathogenesis of T2D. Whether miRNAs like miR-144 could be potential therapeutic targets for management of T2D will need to be explored by further mechanistic and functional studies. miRNA profiling of tissues from T2D rat models. Total RNA (plus miRNAs) was isolated using a modification of the RiboPure™-Blood kit from Ambion (Austin,TX) according to the manufacturer’s protocol. The concentration of total RNA and ...

  9. Gene expression data from adipocytes of insulin resistant mice BioProject

    ID: PRJNA307265

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. L1448 IRS1 Dataverse

    Description: VLA Ka-band data for L1448 IRS1

    Person: Tobin, John

    Release Date: 12-11-2015

  11. Human HAK-1A hepatocellular carcinoma (HCC) cells: TCF-4J-overexpressing clone (under normoxia) vs. TCF-4K-overexpressing clone (under normoxia) BioProject

    ID: PRJNA182174

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: enes associated with Wnt/beta-catenin, Notch, and insulin/IGF-1/IRS1 signal transduction pathway. Overall design: 1 HAK-1A HCC clone overexpressing TCF-4J, 1 HAK-1A HCC clone overexpressing TCF-4K...
  12. Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus ArrayExpress

    ID: E-GEOD-21321

    Description: as significantly higher than in healthy controls. Insulin receptor substrate 1 (IRS1) has been predicted to be a potential target of miR-144. Consistent with this observation, IRS1 mRNA and protein levels, verified by quantitative real-time PCR and western blotting respectively, were found to be down-regulated. Dysregulation in expression of microRNAs (miRNAs) in various tissues has been linked to a wide spectrum of diseases, including Type 2 Diabetes mellitus (T2D). In this study, we compared the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients. Healthy adult males with no past history of T2D (n=158) and with desirable cholesterol and blood pressure profiles were enrolled in this study. They were then classified according to fasting glucose levels to...

  13. IRS1_XENTR UniProt:Swiss-Prot

    ID: Q6P4Y6

    Description: Insulin receptor substrate 1 PH IRS-type PTB YXXM motif 1

  14. Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus. BioProject

    ID: PRJNA141701

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: as significantly higher than in healthy controls. Insulin receptor substrate 1 (IRS1) has been predicted to be a potential target of miR-144. Consistent with this observation, IRS1 mRNA and protein levels, verified by quantitative real-time PCR and western blotting respectively, were found to be down-regulated. Dysregulation in expression of microRNAs (miRNAs) in various tissues has been linked to a wide spectrum of diseases, including Type 2 Diabetes mellitus (T2D). In this study, we compared the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients. Healthy adult males with no past history of T2D (n=158) and with desirable cholesterol and blood pressure profiles were enrolled in this study. They were then classified according to fasting glucose levels to...
  15. Per-emb-53 (B5 IRS1) Dataverse

    Description: VLA Ka-band data for Per-emb-53 (B5 IRS1)

    Person: Tobin, John

    Release Date: 12-11-2015

  16. Transcription profiling by array of liver tissues from mice with liver-specific knockout of Pit1 and wild-type littermates fed with either a high-fat ... ArrayExpress

    ID: E-MTAB-4989

    Description: hich is associated with a risk for development of insulin resistance and type 2 diabetes. In this study, we demonstrate a role for the phosphate inorganic transporter 1 (PiT1/SLC20A1) in regulating metabolism. Specific knockout of Pit1 in hepatocytes significantly improved glucose tolerance and insulin

  17. Type 2 Diabetes mellitus: mRNA and miRNA profiling ArrayExpress

    ID: E-GEOD-26168

    Description: diabetes mellitus. GSE26167: MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus Refer to individual Series...

  18. Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus. OmicsDI

    ID: E-GEOD-21321

    Date Released: 06-10-2011

    Description: as significantly higher than in healthy controls. Insulin receptor substrate 1 (IRS1) has been predicted to be a potential target of miR-144. Consistent with this observation, IRS1 mRNA and protein levels, verified by quantitative real-time PCR and western blotting respectively, were found to be down-regulated. Dysregulation in expression of microRNAs (miRNAs) in various tissues has been linked to a wide spectrum of diseases, including Type 2 Diabetes mellitus (T2D). In this study, we compared the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients. Healthy adult males with no past history of T2D (n=158) and with desirable cholesterol and blood pressure profiles were enrolled in this study. They were then classified according to fasting glucose levels to...

  19. Human HAK-1A hepatocellular carcinoma (HCC) cells: TCF-4J-overexpressing clone (under normoxia) vs. TCF-4K-overexpressing clone (under normoxia) ArrayExpress

    ID: E-GEOD-42512

    Description: enes associated with Wnt/beta-catenin, Notch, and insulin/IGF-1/IRS1 signal transduction pathway. 1 HAK-1A HCC clone overexpressing TCF-4J, 1 HAK-1A HCC clone overexpressing TCF-4K...

  20. IRS1A_XENLA UniProt:Swiss-Prot

    ID: Q91615

    Description: Insulin receptor substrate 1-A IRS-type PTB GRB2-binding YXXM motif


Displaying 20 of 102 results for "IRS1"