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Displaying 20 of 366 results for "IRAK1"
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  1. Crystal structure of IRAK-4 PDB

    ID: PDB:2NRU

    Description: Interleukin-1 receptor-associated kinase 4 (E.C.2.7.11....

  2. IRAK1 drives intestinal inflammation by promoting the generation of effector Th cells with optimal gut homing capacity BioProject

    ID: PRJNA298291

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Crystal structure of IRAK-4 PDB

    ID: PDB:2NRY

    Description: interleukin-1 receptor-associated kinase 4 (E.C.2.7.11....

  4. Crystal Structure of IRAK-4 PDB

    ID: PDB:4RMZ

    Description: Interleukin-1 receptor-associated kinase 4 (E.C.2.7.11....

  5. Expression data from MALP-2-stimulated macrophages from wild-type, IRAK-2-/- and IRAK-1-/IRAK-2-/- mice BioProject

    ID: PRJNA107553

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Transcription profiling of mouse MALP-2-stimulated macrophages FROM wild-TYPE, IRAK-2-/- AND IRAK-1-/IRAK-2-/- animals ArrayExpress

    ID: E-GEOD-10765

    Description: IL-1R-associated kinases (IRAKs) participate in Toll-like receptor (TLR) signal transduction. MALP-2 is a TLR2 ligand,...

  7. Targeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome BioProject

    ID: PRJNA198793

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Inherited human IRAK-1 deficiency selectively abolishes TLR signaling in fibroblasts BioProject

    ID: PRJNA359367

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Targeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome OmicsDI

    ID: E-GEOD-46346

    Date Released: 05-07-2013

    Description: ting the defective MDS clones. We identified that IRAK1, an immune modulating kinase, is overexpressed and hyperactivated in MDS. MDS-propagating clones treated with a small-molecule IRAK1 inhibitor (IRAK1/4-Inh) exhibited impaired expansion and increased apoptosis, which coincided with TRAF6/NF-κB ...

  10. Targeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome ArrayExpress

    ID: E-GEOD-46346

    Description: ting the defective MDS clones. We identified that IRAK1, an immune modulating kinase, is overexpressed and hyperactivated in MDS. MDS-propagating clones treated with a small-molecule IRAK1 inhibitor (IRAK1/4-Inh) exhibited impaired expansion and increased apoptosis, which coincided with TRAF6/NF-κB ...

  11. IRAK1_BOVIN UniProt:Swiss-Prot

    ID: Q2LGB3

    Description: Interleukin-1 receptor-associated kinase 1

  12. Crystal Structure of the Uncomplexed Pelle Death Domain PDB

    ID: PDB:1IK7

    Description: PROBABLE SERINE/THREONINE-PROTEIN Pelle (E.C.2.7.1.37)

  13. cells isolated from patients deficient for IL-1R-associated kinase (IRAK)-4, myeloid differentiation factor 88 (MyD88) and UNC-93B... ArrayExpress

    ID: E-GEOD-13300

    Description: cells isolated from patients deficient for IL-1R-associated kinase (IRAK)-4, myeloid differentiation factor 88 (MyD88) and UNC-93B. Indeed, all TLRs except TLR3 require IRAK-4 and MyD88 to signal and UNC-93B-deficient cells are unresponsive to TLR3, TLR7, TLR8 and TLR9. All patients suffered from defective central and peripheral B cell tolerance checkpoints resulting in t...

  14. Solution Structure of the pelle Death Domain PDB

    ID: PDB:1YGO

    Description: Probable serine/threonine-protein kinase pelle (E.C.2.7.1.37)

  15. IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding PDB

    ID: PDB:3CGO

    Description: Mitogen-activated protein kinase 10 (E.C.2.7.11.24)

  16. IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding PDB

    ID: PDB:3CGF

    Description: Mitogen-activated protein kinase 10 (E.C.2.7.11.24)

  17. THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE PDB

    ID: PDB:1D2Z

    Description: DEATH DOMAIN OF PELLE/TUBE COMPLEX

  18. Cerebellar gene expression profiles of mouse models for Rett Syndrome reveal MeCP2 targets ArrayExpress

    ID: E-GEOD-8774

    Description: dated increased transcript levels for four genes: Irak1, interleukin-1 receptor-associated kinase 1; Fxyd1, phospholemman, associated with Na, K-ATPase; Reln, encoding reelin, an extracellular signaling molecule essential for neuronal lamination and synaptic plasticity; and Gtl2/Meg3, an imprinted maternally expressed non-translated RNA that serves as a host gene for C/D box snoRNAs and microRNAs. Chromatin immunoprecipitation assays documented in vivo MeCP2 binding to promoter regions of Fxyd1, Reln, and Gtl2. Conclusions Transcriptional profiling of cerebellum failed to detect significant global changes in Mecp2-mutant mice. Increased transcript levels of Irak1, Fxyd1, Reln, and Gtl2 may contribute to the neuronal dysfunction in MeCP2-deficient mice and individuals with Rett syndrome. Our data provide testable hypotheses for future studies of the regulatory or signaling pathways that these genes act on. A genetic modification design type is where an organism(s) has had genetic material removed, rearranged, mutagenized or added, such as knock out. Computed...

  19. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans BioProject

    ID: PRJNA109873

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Lymphoid Malignancies BioProject

    ID: PRJNA266478

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 366 results for "IRAK1"