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Displaying 20 of 34 results for "ING4"
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  1. PHD domain of ING4 N214D mutant PDB

    ID: PDB:2M1R

    Description: Inhibitor of growth protein 4

  2. ING4 ChIP-chip in HT1080 cells BioProject

    ID: PRJNA109775

    Keywords: Epigenomics

    Access Type: download

  3. ING4 ChIP-chip in HT1080 cells ArrayExpress

    ID: E-GEOD-13412

    Description: histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a tumor suppressor protein. Here we show a critical role for the specific read-out of histone H3 trimethylated a...

  4. ING4 ChIP-chip in HT1080 cells OmicsDI

    ID: E-GEOD-13412

    Date Released: 05-01-2014

    Description: histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a tumor suppressor protein. Here we show a critical role for the specific read-out of histone H3 trimethylated a...

  5. ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth ArrayExpress

    ID: E-GEOD-42412

    Description: In this report, we have studied the function of ING4, a member of the ING family of tumor suppressors, in the context of normal, non-transformed primary fibroblasts. We show that ING4 negatively regulates cell proliferation in this cell type. The antiproliferative action of ING4 requires its ability to recognize chromatin marks, it is p53-dependent and it is lost in an ING4 cancer-associated m...

  6. ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth BioProject

    ID: PRJNA181347

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth OmicsDI

    ID: E-GEOD-42412

    Date Released: 06-02-2014

    Description: In this report, we have studied the function of ING4, a member of the ING family of tumor suppressors, in the context of normal, non-transformed primary fibroblasts. We show that ING4 negatively regulates cell proliferation in this cell type. The antiproliferative action of ING4 requires its ability to recognize chromatin marks, it is p53-dependent and it is lost in an ING4 cancer-associated m...

  8. MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4 PDB

    ID: PDB:2VNF

    Description: INHIBITOR OF GROWTH PROTEIN 4, HISTONE H3

  9. The PHD finger of ING4 in complex with an H3K4Me3 histone peptide PDB

    ID: PDB:2PNX

    Description: Inhibitor of growth protein 4

  10. Plan homeodomain finger of tumour supressor ING4 PDB

    ID: PDB:2K1J

    Description: Inhibitor of growth protein 4

  11. The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins. PDB

    ID: PDB:4AFL

    Description: INHIBITOR OF GROWTH PROTEIN 4

  12. Solution structure of PHD domain in ING1-like protein BAC25009 PDB

    ID: PDB:1WEU

    Description: inhibitor of growth family, member 4

  13. Solution structure of PHD domain in ING1-like protein BAC25079 PDB

    ID: PDB:1WEN

    Description: inhibitor of growth family, member 4; ING1-like protein

  14. The Transcriptome Responses of Cardiomyocyte Exposed to Hypothermia ArrayExpress

    ID: E-GEOD-71361

    Description: TFs (CPBP, Churchill, NF-AT1, GKLF, SRY, ZNF333, ING4, myogenin, DRI1 and CRX) was recognized to be the functional layer of key nodes, which mapped the signal of hypothermia to transcriptome. These identified DEGs, pathways and predicted TF could facilitate further investigations of the detailed molecular mechanisms, making it possible to take advantage of the potential applications of hypothermia in broader ranger AC16 cell lines was treated by hypothermia (n=3) and control group (n=3) for 6 hours....

  15. The Transcriptome Responses of Cardiomyocyte Exposed to Hypothermia BioProject

    ID: PRJNA291040

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: TFs (CPBP, Churchill, NF-AT1, GKLF, SRY, ZNF333, ING4, myogenin, DRI1 and CRX) was recognized to be the functional layer of key nodes, which mapped the signal of hypothermia to transcriptome. These identified DEGs, pathways and predicted TF could facilitate further investigations of the detailed molecular mechanisms, making it possible to take advantage of the potential applications of hypothermia in broader ranger Overall design: AC16 cell lines was treated by hypothermia (n=3) and control group (n=3) for 6 hours....
  16. Gene expression profiling upon PI3K inhibition using different inhibitors ArrayExpress

    ID: E-GEOD-56579

    Description: razolopyrimidine derivative ETP-45658 as a potent inhibitor of PI3K p110α in vitro and in vivo. Here we report the gene expression signatures of MCF7 cells treated with ETP-45658 or the reference PI3K inhibitor PI-103. Both compounds potently inhibited proliferation of a wide range of human cancer cells. ETP-45658 most potently suppressed the growth of PIK3CA (E545K)-mutate...

  17. ING4_BOVIN UniProt:Swiss-Prot

    ID: Q3T095

    Description: Inhibitor of growth protein 4 PHD-type Bipartite nuclear localization signal Zinc 1 Zinc 1 Zi...

  18. Open chromatin region, histone acetylation, and SREBP2 binding in PANC-1 and AsPC-1 human pancreatic carcinoma cells under hypoxia, nutrient starvatio... BioProject

    ID: PRJNA363000

    Keywords: Epigenomics

    Access Type: download

    dataset.description: genes. Moreover, acyl-CoA synthetase short-chain family member 2 (ACSS2), a direct SREBP2 target, provided a growth advantage to cancer cells under acidic pH. Furthermore, acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients. Thus, our findings show that SREBP2 is a key transcriptional regulator of metabolic genes and progression of cancer cells, partly in response to extracellular acidification. Overall design: For ChIP-seq, PANC-1 cells (1 × 107) were crosslinked with 1% formaldehyde for 10 min at room temperature (RT). Fixation was stopped by adding 0.125 M glycine. After crosslinking, nuclear pellets were prepared for ChIP. Pre-washed magnetic Dynabeads (Life Technologies, Massachusetts, USA) ...
  19. Stimulating BMP4 signaling via HDAC11 inhibition suppresses malignancy in preclinical models of human neuroblastoma BioProject

    ID: PRJNA125531

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: etylase 11 (HDAC11), the most recently identified family member with, as yet, largely unknown function, is recruited to the BMP4 gene promoter and represses its transcription in neuroblastoma. Both HDAC11 depletion and enzymatic inhibition revert the epigenetic silencing of BMP4, thereby blocking a critical oncogenic function of HDAC11. Activated BMP4 signaling through targeting of HDAC11 induces a transcriptional profil...
  20. The Transcriptome Responses of Cardiomyocyte Exposed to Hypothermia OmicsDI

    ID: E-GEOD-71361

    Date Released: 08-20-2015

    Description: TFs (CPBP, Churchill, NF-AT1, GKLF, SRY, ZNF333, ING4, myogenin, DRI1 and CRX) was recognized to be the functional layer of key nodes, which mapped the signal of hypothermia to transcriptome. These identified DEGs, pathways and predicted TF could facilitate further investigations of the detailed molecular mechanisms, making it possible to take advantage of the potential applications of hypothermia in broader ranger AC16 cell lines was treated by hypothermia (n=3) and control group (n=3) for 6 hours....


Displaying 20 of 34 results for "ING4"