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Displaying 20 of 29 results for "IL6ST"
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  1. PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation at the IL6ST (gp130) promoter BioProject

    ID: PRJNA234539

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation at the IL6ST (gp130) promoter ArrayExpress

    ID: E-GEOD-54075

    Description: Analysis of common genes regulated by Tal1 and PADI4 2 controls + 2x3 knockdown samples HEL cells were transduced with lentiviruses harboring shconstr...

  3. Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation ArrayExpress

    ID: E-GEOD-27158

    Description: of Th17 differentiation, IL-2 decreased Il6ra and Il6st/gp130 expression, and Il6st augmented Th17 differentiation even when IL-2 was present. Thus, IL-2 influences T-cell differentiation by modulating cytokine receptor expression to help specify/maintain differentiated states. Genome-wide mapping of STAT1,STAT4,STAT5A,STAT5B binding to their target genes in Th1 or human CD4+ cells was conducted...

  4. IL11_MOUSE UniProt:Swiss-Prot

    ID: P47873

    Description: cell proliferation Important for interaction with IL6ST and for the stimulation of cell proliferation Slightly increases IL11RA binding. Abolishes interaction with IL6ST. Abolishes stimulation of cell proliferation No effect on IL11RA binding...

  5. Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation BioProject

    ID: PRJNA137397

    Keywords: Epigenomics

    Access Type: download

    dataset.description: of Th17 differentiation, IL-2 decreased Il6ra and Il6st/gp130 expression, and Il6st augmented Th17 differentiation even when IL-2 was present. Thus, IL-2 influences T-cell differentiation by modulating cytokine receptor expression to help specify/maintain differentiated states. Overall design: Genome-wide mapping of STAT1,STAT4,STAT5A,STAT5B binding to their target genes in Th1 or human CD4+ cells was conducted...
  6. Oncostatin M (OSM) and Leukemia Inhibitory factor (LIF) treatment of osteoblasts via LIF and OSM receptors BioProject

    ID: PRJNA325836

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: y Factor (LIF) signal within cells via the gp130 (Il6st) coreceptor bound either to the LIF receptor (LIFR) or the oncostatin M receptor (OSMR), but whether murine OSM can act through both receptors is controversial. Both ...
  7. microRNA miR-142-3p induced expression changes in MDA-MB-231 breast cancer cells BioProject

    ID: PRJNA219097

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cytoskeletal regulation and cell motility. ROCK2, IL6ST, KLF4, PGRMC2 and ADCY9 were identified as additional targets in a subset of cell lines. Decreased matrigel invasiveness was associated with the miR-142-3p-induced expression changes. Confocal immunofluorescence microscopy, nanoscale atomic force microscopy and digital holographic microscopy revealed a change in cell morphology as well as a reduced cell volume and size. A more cortical actin distribution and a loss of membrane protrusions were observed in cells overexpressing miR-142-3p. Luciferase activation assays confirmed direct miR-142-3p-dependent regulation of the 3'-untranslated region of ITGAV and WASL. siRNA-mediated depletion of ITGAV andWASL resulted in a significant reduction of cellular invasiveness, highlighting the contribution of these factors to the miRNA-dependent invasion phenotype. While knockdown of WASL significant...
  8. TGF-beta/atRA induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation [miRNA] BioProject

    ID: PRJNA362603

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: qPCR results showed that the expression of IL6R, IL6ST, JAK1 and STAT3 (heavily targeted by identified miRs) are all downregulated in CD4TGF/atRA, as compared to CD4med and naïve T cells. Finally, we show that selected synthetic mimics (namely, miR-23a, -30a, -636 and -1299) are able to knockdown IL6R and IL6ST transcript levels, functionally inhibiting IL-17 expression and favoring the generation of FOXP3+ cells. Our work adds novel evidences supporting the central roles played by microRNAs in the post-transcriptional regulation of major pathways involved in the generation and function of regulatory T cells. Overall design: In order to identify potential microRNA/mRNA regulatory mechanisms involved in the specific roles of TGF-β and atRA in the generation of iTregs, we evaluated and compared the microRNA and mRNA expression profiles of fleshly isolated umbilical cord blood (UCB) naïve T cells and of cells activated with anti-human CD2/CD3/CD28 beads in the presence of IL-2 alone (CD4Med) or with the addition of TGF-β and atRA (CD4TGF/atRA). Microarray profiling was performed for freshly isolated naïve T cells and the corresponding CD4TGF/atRA and CD4Med cells, derived in culture, from three UCB samples (totaling 9 microarray profiles)....
  9. IL11_RAT UniProt:Swiss-Prot

    ID: Q99MF5

    Description: cell proliferation Important for interaction with IL6ST and for the stimulation of cell proliferation...

  10. Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation OmicsDI

    ID: E-GEOD-27158

    Date Released: 08-22-2013

    Description: of Th17 differentiation, IL-2 decreased Il6ra and Il6st/gp130 expression, and Il6st augmented Th17 differentiation even when IL-2 was present. Thus, IL-2 influences T-cell differentiation by modulating cytokine receptor expression to help specify/maintain differentiated states. Genome-wide mapping of STAT1,STAT4,STAT5A,STAT5B binding to their target genes in Th1 or human CD4+ cells was conducted...

  11. PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation at the IL6ST (gp130) promoter OmicsDI

    ID: E-GEOD-54075

    Date Released: 06-07-2014

    Description: Analysis of common genes regulated by Tal1 and PADI4 2 controls + 2x3 knockdown samples HEL cells were transduced with lentiviruses harboring shconstr...

  12. Accurate prediction and validation of response to endocrine therapy in breast cancer ArrayExpress

    ID: E-GEOD-59515

    Description: treatment (one associated with immune signalling, IL6ST and the other with apoptosis, NGFRAP1) and two proliferation genes (ASPM, MCM4) at 2 weeks of therapy. The four gene signature was found to be 91% accurate in a blinded, completely independent validation dataset of patients treated with anastrozole. Matched 2 week on-treatment biopsies improved predictive power over pre-treatment biopsies alone. This signature also significantly predicted recurrence free survival (p=0.029) and breast cancer specific survival (p=0.009). We demonstrate that the test can also be performed using quantitative PCR or immunohistochemistry. Conclusion A four gene predictive model of clinical response to AIs by two weeks has been generated and validated. Deregulated immune and apoptotic responses before treatment and a failure to reduce proliferation by 2 weeks are functional characteristics of breast tumours that do not respond to AIs. 25 Pre treatment, 25 two week and 25 three month on-treatment p...

  13. TGF-beta/atRA induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation [mRNA] BioProject

    ID: PRJNA362607

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: qPCR results showed that the expression of IL6R, IL6ST, JAK1 and STAT3 (heavily targeted by identified miRs) are all downregulated in CD4TGF/atRA, as compared to CD4med and naïve T cells. Finally, we show that selected synthetic mimics (namely, miR-23a, -30a, -636 and -1299) are able to knockdown IL6R and IL6ST transcript levels, functionally inhibiting IL-17 expression and favoring the generation of FOXP3+ cells. Our work adds novel evidences supporting the central roles played by microRNAs in the post-transcriptional regulation of major pathways involved in the generation and function of regulatory T cells. Overall design: In order to identify potential microRNA/mRNA regulatory mechanisms involved in the specific roles of TGF-β and atRA in the generation of iTregs, we evaluated and compared the microRNA and mRNA expression profiles of fleshly isolated umbilical cord blood (UCB) naïve T cells and of cells activated with anti-human CD2/CD3/CD28 beads in the presence of IL-2 alone (CD4Med) or with the addition of TGF-β and atRA (CD4TGF/atRA). Microarray profiling was performed for freshly isolated naïve T cells and the corresponding CD4TGF/atRA and CD4Med cells, derived in culture, from three UCB samples (totaling 9 microarray profiles)....
  14. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours ArrayExpress

    ID: E-GEOD-11819

    Description: onse to somatic gain-of-function mutations in the IL6ST gene that encodes the signalling co-receptor gp130. Indeed, ~70% of IHCA harbour small in-frame deletions that target the binding site of gp130 for IL6, and expression of the most frequent gp130 mutant, Delta-STVY190, in hepatocellular cells activates STAT3 in absence of ligand. Further, analysis of hepatocellular carcinomas revealed rare gp130 alterations always accompanied by ß-catenin-activating mutations, suggesting a cooperative effect of these signalling...

  15. IL11_MACFA UniProt:Swiss-Prot

    ID: P20808

    Description: cell proliferation Important for interaction with IL6ST and for the stimulation of cell proliferation...

  16. IL6RB_RAT UniProt:Swiss-Prot

    ID: P40190

    Description: Interleukin-6 receptor subunit beta Extracellular Helical Cytoplasmic Ig-like C2-type Fibronectin type-III 1 Fibronectin type-III 2 Fibronectin type-I...

    gene.name: Il6st
  17. Accurate prediction and validation of response to endocrine therapy in breast cancer BioProject

    ID: PRJNA255496

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: treatment (one associated with immune signalling, IL6ST and the other with apoptosis, NGFRAP1) and two proliferation genes (ASPM, MCM4) at 2 weeks of therapy. The four gene signature was found to be 91% accurate in a blinded, completely independent validation dataset of patients treated with anastrozole. Matched 2 week on-treatment biopsies improved predictive power over pre-treatment biopsies alone. This signature also significantly predicted recurrence free survival (p=0.029) and breast cancer specific survival (p=0.009). We demonstrate that the test can also be performed using quantitative PCR or immunohistochemistry. Conclusion A four gene predictive model of clinical response to AIs by two weeks has been generated and validated. Deregulated immune and apoptotic responses before treatment and a failure to reduce proliferation by 2 weeks are functional characteristics of breast tumours that do not respond to AIs. Overall design: 25 Pre treatment, 25 two week and 25 three mont...
  18. Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex PDB

    ID: PDB:1P9M

    Description: Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain

    gene.name: IL6ST
  19. Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes PDB

    ID: PDB:3L5H

    Description: Interleukin-6 receptor subunit beta

    gene.name: IL6ST
  20. Crystal structure of FnIII domains of human GP130 (Domains 4-6) PDB

    ID: PDB:3L5I

    Description: Interleukin-6 receptor subunit beta

    gene.name: GP130, IL6ST

Displaying 20 of 29 results for "IL6ST"